MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
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greenlocus
New Member
Yea, no TRT or anything else so far. With HGH I am aiming for increased muscle mass, reduced body fat, faster workout recovery, and better sleep. I'm only in my second month of 3 iu/day and can't tell much yet.
phenominal34
Banned
HGH isnt a common thing discuss because I havnt dabbled in it nor have I done enough research. But from what I do know, if you’re not on AAS (Test at least) the things you listed aren’t going to be that advanced !!
oldmanwilliams
Member
Guys, for reconstituting Tirzepatide 30mg vials, what is the best amount of water to use?
Ghoul
Member
oldmanwilliams
Member
But Ghoul, didn't you say (or perhaps I imaged I read), that these higher potency vials require larger amounts of water to prevent aggregates or something along those lines? So what is really the optimal amount of water needed here? In my situation, I'll start with 7.5mg but I thought the dosing doesn't really matter when it comes to the truly apparent amount of water needed here.
I don't know if it's the right place to ask this but I wouldn't were else to ask: could I be mistaking acid reflux for hunger?
I alway have a sensation of burning/hunger under my lower ribs and above my stomach area. it feels like hunger so it incites me to eat but I think it's not hunger. I've had it for as long as I can remember (since I was a kid) and it's 24/7, it only goes away for an hour or two after I drink coffee. Low carb diets or fasting has never helped. Eating starchy foods or lying down reduces it a little. Any feedback? thanks.
I alway have a sensation of burning/hunger under my lower ribs and above my stomach area. it feels like hunger so it incites me to eat but I think it's not hunger. I've had it for as long as I can remember (since I was a kid) and it's 24/7, it only goes away for an hour or two after I drink coffee. Low carb diets or fasting has never helped. Eating starchy foods or lying down reduces it a little. Any feedback? thanks.
greenlocus
New Member
From what I understand, it's not uncommon for people to take 2 or 3 iu daily for general longevity and health.
greenlocus
New Member
Thanks Ghoul, just ordered some. I understand Reta is a triple agonist but what are the positives of Reta besides the appetite suppression? Is it better for maintaining muscle while in a deficit?
Curious if you decided to run this experiment with pioglitazone. I'd be interested to hear any feedback.
Pioglitazone caught my attention recently. I might consider running this during my next bulk for better fat partitioning.
Ghoul
Member
Lower side effects.
All the GLPs reduce psychological appetite.
But Sema (the strongest sides) and Tirz (less sides) also impose a physical "punishment" of GI sides if you eat too much.
Reta doesn't do this nearly as much.
So users say they lose the "food noise", but can eat if they want to.
This is an advantage for bodybuilders, already generally disciplined, who take advantage of reduced appetite to manage what they're eating to achieve the desired outcome.
In my opinion, undisciplined "normal" people often benefit from the harsher suppression of Sema or Tirz so they learn not to "eat behind their appetite", while for a BB feeling sick after eating a meal they know they need is not helpful.
On a biological level, Reta does a better job of blunting metabolic adaptation. It keeps up, and even increases Resting Energy Expenditure which normally goes down as calories are cut.
Some people also say they feel less fatigue on Reta.
Finally, Reta seems to provide better glucose control at doses low enough to not cause too much appetite suppression (or none at all), which is useful for GH users not looking to drop weight but want to counter insulin resistance.
bananafeet
Member
I ran up to 3mg of Tracy's semaglutide per week split into two doses a few months back.
It slowed my stomach down so much I was concerned it had stopped (resolved after coming off). I remember being able to eat one decent meal in a 12 hour window. For example eating a semi decent dinner would leave me unable to eat until 10am. If I pushed it and ate breakfast that would push the window back till midday.
I remember one day getting excited about eating some choc chip cookies. I had two large ones and thought I had gotten away with it. Violently vomitted that shit up 2 hours later
It's strong stuff and not to be underestimated! I am also thoroughly convinced that people with eating disorders make up side effects because it ruins their drug of choice: food .
Even the loading dose of sema makes binge eating uncomfortable or not as enjoyable. The crazy thing is you gravitate to "healthy" foods you can digest. Like lean meats, veggies, yoghurt and fruit.
I'm a sema fan boi. But it must be respected. It's like the tren of GLP1s
Eddie.
Member
I have a question for the guys that used/using a higher dose of reta. Do you find the fat loss effects more pronounced when you increase the dose or the higher dose has an effect strictly on appetite reduction?
I'm currently on 1,8mg eod, my appetite and cravings is the same and the only thing i notice regarding food, is i can get fuller faster without eating the whole table lol.
I just wonder if there's a point keeping reta at this pace for 4 weeks until i quit my cutting phase or go to something like 1,5mg a week from now. If any excess fat loss is happening due to higher dose I'd like to keep it.
I'm currently on 1,8mg eod, my appetite and cravings is the same and the only thing i notice regarding food, is i can get fuller faster without eating the whole table lol.
I just wonder if there's a point keeping reta at this pace for 4 weeks until i quit my cutting phase or go to something like 1,5mg a week from now. If any excess fat loss is happening due to higher dose I'd like to keep it.
Currently running it and still got a ton of pharma stuff left from it, it takes 3-6 months to fully show its benefits
Photon
Member
You seem to be on every med that reduces hba1c lol
Do you have a ranking of products that drops it the most?
I'm looking for something else to add besides SGLT1/2 & GLP.
Metformin ER and immediate both mess with my stomach bad.
the~club~bro
New Member
Ive been running SA TR30 for 1 week now. I find it interesting that Tirz makes me feel sickly full from the consumption of fluids (flavoured water in this case). I don't recall this sensation at all using semaglutide, be it UGL or Novo Nordisk.
Last week I also had a totally inexplicable weight increase that was so out of the ordinary. Weighed in at 179.5 on the Monday, had ballooned up to 185.4 by Thursday. Today, weighed in at 177.7. Absolutely nothing in my activity, eating or drinking to account for it.
Just goes to show, you have to track this shit week to week.
Last week I also had a totally inexplicable weight increase that was so out of the ordinary. Weighed in at 179.5 on the Monday, had ballooned up to 185.4 by Thursday. Today, weighed in at 177.7. Absolutely nothing in my activity, eating or drinking to account for it.
Just goes to show, you have to track this shit week to week.
Ghoul
Member
In the trials Resting Energy Expenditure rose sharply starting at 6mg.
Below that the "free extra calorie burn" falls off a cliff.
Not a huge dose considering the they expect people to use start a 2 and titrate up to 12.
Eddie.
Member
Great, thank you! I'm gonna raise it a tad more then and ride the last weeks of cutting.
Ghoul
Member
The great strength of Reta is that REE doesn't drop like it normally would with calorie restriction as the body slows metabolism to conserve energy. And starting at 6mg, it drives it higher burning off even more than normal.
Tirz maintains some REE too but Reta is the king of this effect because of Glucagon agonism.
It contains an antibody component, thereby necessitating costly recombinant expression.
I’m not sure this one will come onto the ugl market.
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