Cholesterol numbers on no med, then on statin then on statin + Repatha

[Photon]

Trig / hdl-c ratio still gives you what you need to know on the cheap. Mine was incredible on a shit load of coconut oil.

Tell me I'm wrong.

The Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio as a Risk Marker for Metabolic Syndrome and Cardiovascular Disease - PMC

Atherosclerosis is an immunoinflammatory pathological procedure in which lipid plaques are formed in the vessel walls, partially or completely occluding the lumen, and is accountable for atherosclerotic cardiovascular disease (ASCVD). ACSVD consists ...

pmc.ncbi.nlm.nih.gov

Throw in fasting insulin as well.

R

Post in thread 'HGH and Metformin dosage?'

Feb 2, 2025

I assume your talking about triglycerides, how does that calculation work exactly? my fbg is around 85-90 and my triglycerides are 61?

Excellent job.

Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome - PubMed

TyG index is superior to HOMA-IR for predicting MetS.

pubmed.ncbi.nlm.nih.gov

TyG Index Calculator

This TyG index calculator determines insulin resistance and can also identify individuals at risk for NAFLD.

www.mdapp.co

• readalot

• 

My fasting trigs is around 30s.
Isocapent will probably drop the trigs even lower

I'm fine with very low LDL but not entire sure about very low single digit trigs..

I'll order some coconut oil to play with lol
My HDL took a pretty big hit when i started dropping my LDL but thats to be expected.

 

[Wizbang]

Trig / hdl-c ratio still gives you what you need to know on the cheap. Mine was incredible on a shit load of coconut oil.

Tell me I'm wrong.

The Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio as a Risk Marker for Metabolic Syndrome and Cardiovascular Disease - PMC

Atherosclerosis is an immunoinflammatory pathological procedure in which lipid plaques are formed in the vessel walls, partially or completely occluding the lumen, and is accountable for atherosclerotic cardiovascular disease (ASCVD). ACSVD consists ...

pmc.ncbi.nlm.nih.gov

Throw in fasting insulin as well.

R

Post in thread 'HGH and Metformin dosage?'

Feb 2, 2025

I assume your talking about triglycerides, how does that calculation work exactly? my fbg is around 85-90 and my triglycerides are 61?

Excellent job.

Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome - PubMed

TyG index is superior to HOMA-IR for predicting MetS.

pubmed.ncbi.nlm.nih.gov

TyG Index Calculator

This TyG index calculator determines insulin resistance and can also identify individuals at risk for NAFLD.

www.mdapp.co

• readalot

• 

my tri/hdl ratio is 1.14 currently, I will need to brush up on some of this reading.

 

[readalot]

My fasting trigs is around 30s.
Isocapent will probably drop the trigs even lower

I'll order some coconut oil to play with lol
My HDL took a pretty big hit when i started dropping my LDL but thats to be expected.

Hdl-c?

 

[Photon]

Hdl-c?

It went from 4x to 2x when i dropped my LDL to single digits.

 

[readalot]

It went from 4x to 2x when i dropped my LDL to single digits.

x = ?

 

[Photon]

x = ?

x = *

20-30
40-50

 

[Ghoul]

So far the only risk of single digit LDL that seem to have any credibility is fat soluble vitamin issues and hormone synthesis. But this hasn't been proven. and single digit LDL is very rare even with the most powerful lipid lowering stack.

The people with genetic mutations that cause PCSK9 Loss of Function often have LDL-C of around 10.

They've been followed for decades and haven't exhibited any of the hypothesized issues from "too low" LDL. No increased cancer, hormone issues, neurological problems (the brain makes
its own LDL when needed).

All that's been observed is 90% fewer heart attacks and strokes.

Those people were the inspiration for PCSK9 inhibitor drugs (antibodies grown in hamster cells that attack pCSK9).

For those who don't know, PCSK9 is a protein we produce that reduces the ability of the liver to clear LDL. This seems to be a now useless evolutionary trait that helped our ancestors stay alive longer in an environment where sepsis was common. High LDL is believed to slow the progression of sepsis infections.

Since lifespans were so short, this was an advantage since almost no one lived long enough to develop arteriosclerosis anyway.

 

[BamaCrazy]

My fasting trigs is around 30s.
Isocapent will probably drop the trigs even lower

I'm fine with very low LDL but not entire sure about very low single digit trigs..

I'll order some coconut oil to play with lol
My HDL took a pretty big hit when i started dropping my LDL but thats to be expected.

Other than real health issues like malnutrition and hormonal imbalances that can cause low triglycerides, the only possible risk is cognitive function. But the research is lacking.

“The brain requires adequate fats for optimal performance, and very low triglycerides could potentially affect memory, concentration, and mood regulation.”

 

[Wizbang]

I removed coconut milk from my diet, because it spiked my LDL. It's also the most potent dietary booster of high quality HDL(it increases efflux not just quantity), vs low quality HDL like niacin. But on balance, it does more harm than good because of the huge LDL boost.

Repatha, Eze, Pita, suppress the LDL increase of 200ml / day of coconut milk, with the net effect being an increase in HDL and efflux that should boost potential regression by ~1.5-2.5% / year, far outweighing any negative impact of the suppressed LDL increase expected to be 0-10 points, clinically insignificant when we're talking about LDL below 40.

On just Pita, Eze 100ml of coconut milk maximizes HDL benefit before LDL outweighs it. Add Isocapent and that rises to 150ml..

I'm going to get a new lipid baseline this week and reintroduce coconut milk to see how this plays out in real life.

So if I am trying to boost HDL while on repatha + icosapent... coconut milk is the way?

 

[Nidus]

Considering the concern over Tryg. here, anyone ever looked at Carnitin?

600mg Carnitin keeps my Tryg at 70
1200 around 50 and with 1800mg at the moment they barely touch 45

 

[MarkusLA]

Considering the concern over Tryg. here, anyone ever looked at Carnitin?

600mg Carnitin keeps my Tryg at 70
1200 around 50 and with 1800mg at the moment they barely touch 45

Oral L-Carnitine?

What are your triglycerides with no Carnitine?

 

[MarkusLA]

So far the only risk of single digit LDL that seem to have any credibility is fat soluble vitamin issues and hormone synthesis. But this hasn't been proven. and single digit LDL is very rare even with the most powerful lipid lowering stack.

The people with genetic mutations that cause PCSK9 Loss of Function often have LDL-C of around 10.

They've been followed for decades and haven't exhibited any of the hypothesized issues from "too low" LDL. No increased cancer, hormone issues, neurological problems (the brain makes
its own LDL when needed).

All that's been observed is 90% fewer heart attacks and strokes.

Those people were the inspiration for PCSK9 inhibitor drugs (antibodies grown in hamster cells that attack pCSK9).

For those who don't know, PCSK9 is a protein we produce that reduces the ability of the liver to clear LDL. This seems to be a now useless evolutionary trait that helped our ancestors stay alive longer in an environment where sepsis was common. High LDL is believed to slow the progression of sepsis infections.

Since lifespans were so short, this was an advantage since almost no one lived long enough to develop arteriosclerosis anyway.

This is great info. Do you have any links to the studies/reports of people with PSK9 loss of function?

 

[Ghoul]

This is great info. Do you have any links to the studies/reports of people with PSK9 loss of function?

Here are two large scale studies on people with PCSK9 Loss of Function genetic mutations giving them naturally very low LDL:

https://pmc.ncbi.nlm.nih.gov/articles/PMC7652310/

https://diabetesjournals.org/care/article/45/1/251/138983/Effect-of-Loss-of-Function-Genetic-Variants-in

TLDR: No negative impact on lifespan, cancer rates, insulin sensitivity, liver function, or signs of cognitive issues, just lower risk of cardiovascular disease.

"Our results do not support adverse effects of PCSK9 pLoF variants on glycemic traits, hepatobiliary function, or neurocognitive traits"

---------

Similar findings with subjects using PCSK9 inhibiting antibody drugs to achieve an artificial "loss of PCSK9 function":

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061620

TLDR: Patients on PCSK9 inhibitors and statins, with LDL-C down to 8, followed up over 8.5 years, also showed no negative impact on health, including neurological, insulin sensitivity, hemorrhage, or cataract issues. (increased risk of hemorrhage or cataracts were the latest theoretical risks from extremely low LDL suggested by some scientists when this study was started, which is why they were specifically looked at). Cardiovascular risk continued to decrease as LDL went all the way down to 8:


“There was a monotonic relationship between achieved LDL cholesterol and major cardiovascular outcomes down to LDL cholesterol concentrations of less than 0.2 mmol/L (LDL-C 8).

There was no significant association between achieved LDL cholesterol and adverse safety outcomes, including neurocognitive events, new-onset diabetes, hemorrhagic stroke, or cataracts.”

— FOURIER-OLE investigators, 2023 (The Lancet)

 

[Nidus]

Oral L-Carnitine?

What are your triglycerides with no Carnitine?

Injectable, without it it my Tryg. go up to 82.
I take it as Tryg. are also linked to Insulin Sensitivity and Fatty Liver as a precaution but also for Mitochondrial health, heart heart and making fat loss easier

 

[MarkusLA]

Injectable, without it it my Tryg. go up to 82.
I take it as Tryg. are also linked to Insulin Sensitivity and Fatty Liver as a precaution but also for Mitochondrial health, heart heart and making fat loss easier

Interesting. And your doses are daily, right?

I went looking for studies and found some that showed a small improvement in Trigs from 1-2g of carnitine (i.e. 10 points), but they were using oral carnitine. You're seeing an improvement of 35 points with the same dose. Maybe injection is what makes that difference.

 

[Ghoul]

I forgot to mention. From what I've been able to deduce, the concerns about very low LDL and Triglycerides originated from observations in cancer patients and people with neurodegeneration having low LDL and TG.

It's now been established that certain cancers lower LDL, especially in the very early, often undetected stages.

Low triglycerides are a sign of poor nutrition, which is a common symptom of cognitive decline.

 

[Nidus]

Interesting. And your doses are daily, right?

I went looking for studies and found some that showed a small improvement in Trigs from 1-2g of carnitine (i.e. 10 points), but they were using oral carnitine. You're seeing an improvement of 35 points with the same dose. Maybe injection is what makes that difference.

Injectable Carnitine has so many benefits, just take the AR upregulation with a grain of salt.

 

[readalot]

https://www.sciencedirect.com/science/article/abs/pii/S1530891X25000606

Conclusion
TG/HDL-C ratio was strongly associated with HRP, HS, and cardiac events in patients with FH treated with long-term cholesterol-lowering therapy.

Cut back on the oxandrolone/stanozolol. Do more with less total androgen load. Thank you for your attention.

 

[Photon]

“The brain requires adequate fats for optimal performance, and very low triglycerides could potentially affect memory, concentration, and mood regulation.”

Low triglycerides are a sign of poor nutrition, which is a common symptom of cognitive decline.

Kind of my concern too.
My fasting trigs has always been around 30 regardless of my LDL level.

 

[Ghoul]

Kind of my concern too.
My fasting trigs has always been around 30 regardless of my LDL level.

I'm surprised that hasn't been looked into. Hyperthyroidism can cause levels like that, naturally or from excessive T4/T3 supplementation.

From a very normal 100, Ezetimebe, Pita 4, and Repatha and isocapent only brings it down to 50-60.