And on that note, this thread has actually been excellent for hearing from some people that used high dose. The majority of accounts you read about online are from teens using quite low doses so I probably never would have gotten to these highs without the anecdotes in this thread - thanks again.
MESO-Rx
Anabolic Steroids
Accutane permanent cure?
- Thread starter Ghoul
- Start date
PopeyeTheSailerDude
Member
Aquaphor is the VIP for lips. Plus I had to use Elizaveth Arden moisturiser for my whole body and Vaseline up my nose. Special shower gel too. It’s been 4/5 years since my last course and I still have the dry skin on my arms/legs/back from it. But as we know it’s all worth it to get rid of the acne.
I just googled and I see it does say max dose is 200per on some sites so maybe things have changed. Both times the doc told me I’m at max at 1 per kg. And both times I did it was summer too so i guess it just exacerbates the sides. I litrally hid from the sun too.
I always considered just having the dryness for sides a lucky outcome but man I’m jealous of you being on that much and just having the dry lips. Anyway may your sides stay low and your acne be gone. GL
Ghoul
Member
I started down this path with extreme concern over the horror stories regarding side effects and risks, hoping the fact low dose protocols were suggested to be effective was a way to avoid both. In the end, after starting treatment I realized it wasn't as bad as I expected, initial results were impressive, and the data's pretty clear that over many decades of clinical experience the risks are much less than most people have been led to believe (but there are some ofc). Sides can be unpleasant but are temporary and manageable, and especially for body acne, high dose cumulative is the only proven method to have a decent chance at not having to repeat treatment ever again. It was also telling high doses are most common in high end private pay clinics. where the fact insurance won't pay for higher doses wasn't an issue, and dermatologists were free to use the protocol they found most effective. The meds alone for 200mg/kg in the US are $3-4k (vs ~$150 from India).
“At 1 year after completion of isotretinoin treatment, we found that patients receiving 220 mg/kg or more had a significantly decreased risk of relapse. Rash was the only adverse effect that was significantly more common in the high-dose group during treatment.” 
pubmed.ncbi.nlm.nih.gov
“Isotretinoin prescribed at 1.5 mg/kg/day or greater for 5–6 months [cumulative total dose of 290 mg/kg] is safe and effective compared to current standard dosing practices. One-hundred percent of patients were disease-free upon completion of treatment. During the three-year study period, 10 patients (12.5%) developed a relapse.” 
pubmed.ncbi.nlm.nih.gov
“Of 720 patients, 116 received a cumulative dose >200 mg/kg. Fifty-two patients (7.2%) reported persistent symptoms during the follow-up period; no dose-related serious adverse effects were observed.” 
pubmed.ncbi.nlm.nih.gov
“At 1 year after completion of isotretinoin treatment, we found that patients receiving 220 mg/kg or more had a significantly decreased risk of relapse. Rash was the only adverse effect that was significantly more common in the high-dose group during treatment.” 
High-dose isotretinoin treatment and the rate of retrial, relapse, and adverse effects in patients with acne vulgaris - PubMed
The dosing regimen used in the present study is considerably higher than that used in previous studies of isotretinoin. At 1 year after completion of isotretinoin treatment, we found that patients receiving 220 mg/kg or more had a significantly decreased risk of relapse. Rash was the only...
pubmed.ncbi.nlm.nih.gov
“Isotretinoin prescribed at 1.5 mg/kg/day or greater for 5–6 months [cumulative total dose of 290 mg/kg] is safe and effective compared to current standard dosing practices. One-hundred percent of patients were disease-free upon completion of treatment. During the three-year study period, 10 patients (12.5%) developed a relapse.” 
High-dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life - PubMed
Isotretinoin prescribed at 1.5 mg/kg/day or greater for 5-6 months [cumulative total dose of 290 mg/kg] is safe and effective compared to current standard dosing practices. We propose the use of high-dose isotretinoin (>1.3 mg/kg/day) as a treatment option in severe nodulocystic acne and encourag …
pubmed.ncbi.nlm.nih.gov
“Of 720 patients, 116 received a cumulative dose >200 mg/kg. Fifty-two patients (7.2%) reported persistent symptoms during the follow-up period; no dose-related serious adverse effects were observed.” 
Long-term safety of isotretinoin as a treatment for acne vulgaris - PubMed
We assessed possible long-term side-effects of isotretinoin therapy in 720 patients who had received one or more courses of treatment, and had a mean follow-up period of 4.9 years (range 2-12 years). Most patients (442) had received a total cumulative dose of 120-200 mg/kg body weight. One...
pubmed.ncbi.nlm.nih.gov
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Thank you very much bro. I read all the horror stories and went so over the top with all the shit I bought to deal with potential sides. And all in all the aquaphor was all I needed. I bought like a bunch of demisters for dry eyes and shit like that but haven't had any problems at all.
I don't tend to be in the sun that often for the sake of it but I do have sporting gamedays where I'll be out in the sun for hours. (5 hours+ is not out of the question) I just liberally apply SPF50 sunscreen as I normally would have even prior to using Accutane and haven't had any issues again at all.
That sucks that you've still got the dryness and stuff but hey at least your skincare routine is probably on point now lol, and like you said - worth it to get rid of the acne.
Cheers again bro
I started down this path with extreme concern over the horror stories regarding side effects and risks, hoping the fact low dose protocols were suggested to be effective was a way to avoid both. In the end, the data's pretty clear that over many decades of clinical experience the risks are much less than most people have been led to believe (but there are some ofc), the sides can be unpleasant but are temporary and manageable, and especially for body acne, high dose cumulative is the only proven method to have a decent chance at not having to repeat treatment ever again.
“At 1 year after completion of isotretinoin treatment, we found that patients receiving 220 mg/kg or more had a significantly decreased risk of relapse. Rash was the only adverse effect that was significantly more common in the high-dose group during treatment.” 
High-dose isotretinoin treatment and the rate of retrial, relapse, and adverse effects in patients with acne vulgaris - PubMed
The dosing regimen used in the present study is considerably higher than that used in previous studies of isotretinoin. At 1 year after completion of isotretinoin treatment, we found that patients receiving 220 mg/kg or more had a significantly decreased risk of relapse. Rash was the only...
“Isotretinoin prescribed at 1.5 mg/kg/day or greater for 5–6 months [cumulative total dose of 290 mg/kg] is safe and effective compared to current standard dosing practices. One-hundred percent of patients were disease-free upon completion of treatment. During the three-year study period, 10 patients (12.5%) developed a relapse.” 
High-dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life - PubMed
Isotretinoin prescribed at 1.5 mg/kg/day or greater for 5-6 months [cumulative total dose of 290 mg/kg] is safe and effective compared to current standard dosing practices. We propose the use of high-dose isotretinoin (>1.3 mg/kg/day) as a treatment option in severe nodulocystic acne and encourag …
“Of 720 patients, 116 received a cumulative dose >200 mg/kg. Fifty-two patients (7.2%) reported persistent symptoms during the follow-up period; no dose-related serious adverse effects were observed.” 
Long-term safety of isotretinoin as a treatment for acne vulgaris - PubMed
We assessed possible long-term side-effects of isotretinoin therapy in 720 patients who had received one or more courses of treatment, and had a mean follow-up period of 4.9 years (range 2-12 years). Most patients (442) had received a total cumulative dose of 120-200 mg/kg body weight. One...
Love this. It's good to know that 2 months down the line I will have pretty much done what I need to in order to sort it out.
Also, seeing as you're around - bought myself 8 weeks worth of Ivermectin like you mentioned earlier on in the thread. Is it worth me starting to use it now or should I wait until the course of Accutane is over?
I had bloodwork taken on Monday too, will be interesting to see how my liver results are. I take TUDCA and have some glutathione that I'm not currently using but definitely will start using if the liver results are not good.
If they are good though (and I suspect they will be), I'm even tempted to up it to 240mg a day.
Ghoul
Member
Since Demodex feeds on sebum, and by the end of the course you'll produce much less, I think it's best to leave the Ivermectin until you're finished. This way after clearing them out, your skin environment will be much less hospitable to them recolonizing it.
Thanks man, will do!
Ghoul
Member
To minimize sides, yes. Keeps peak levels of the drug lower. Make sure to use around the time you've consumed some fat for proper absorption.
Spaceman Spiff
Subscriber
Make sure you test your products too to ensure adequate dosing.
They’re India Pharma Accufine. Hopefully they’re the correct listed dosage.
Spaceman Spiff
Subscriber
Not much proof says it's accurate lol
Photon
Member
I used the really really expensive one by Sun Pharma.
Tested as 20% under by PctZone.
Whether they were underdosed or they degraded because accutane degrades easily under heat (India is very hot 24/7), who knows, but that's not the point. The point is to hit the cumulative dosage and it's hard to do so without knowing how much product is actually in your batch, especially if yours is close to the expiry date.
I took up to 260mg/day during my run with minimal sides, was honestly surprised. On hind side, it was because that 260mg was only ~200mg or even less.
mandragora33
New Member
Hi Ghoul,
I saw that you increase a lot your dosages. Each time you up your dosage, does you see purge each time? Actually purging a lot.
Also : Is accufine really okay for the treatment? We heard good and bad about Healing Pharma. But most of the time I see labtest around 50 to 90%. I just bought my cumulative dose of 150mg/kg with Accufine.
Used UGL tablets to start (and was way more pricey)
Thanks.
Had the bloodwork done last wednesday after leg workout(evening before). To my suprise everything was in range, but slightly elevated ASAT(+16) and ALAT(+24) probably from combination of taking accutane 2x a week for almost 4months, few weeks on nolva and the leg workout lol. So sadly no prescription for me.
Ordered some from Driada. Anyone tried their accutane? Couldn't find any reports in this thread.
Ordered some from Driada. Anyone tried their accutane? Couldn't find any reports in this thread.
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Spaceman Spiff
Subscriber
Order some stuff, do some testing, get reimbursed.
Makee sure it's properly dosed. Indian sources will reimburse
Photon
Member
I was not aware.
The last time i asked for testing of medication at Jano that was not in his quotation list, i was quoted 300++. Let me check with the PCT sources on their reimbursement policy.
Vrjorp
Member
Been on prescribed accutane for about a year now, starting from 20mg EOD to now 40mg one and 60mg the other day rotating, finally starting to work wonders for very stubborn neck and chest acne.
Barely get any sides apart from the dry lips/skin and occasional bleeding nose. No lethargy etc.
Barely get any sides apart from the dry lips/skin and occasional bleeding nose. No lethargy etc.
Did the acne pre-date any anabolic use?
Vrjorp
Member
Yes was always prone to acne with oily skin, but got extremely bad on DHTs
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