Triptorelin messed me up. Help Needed

[flasspass123]

Hey guys, currently 29 years old. I was on gear, just testosterone from 2018-2019. PCTed during covid in 2020 with clomid, and took some letro as my e2 got high.

Things were going decent and I decided to take 100mcg of a non-pharmaceutical version of triptorelin to finish off the pct. After this injection my health has not been the same since. I developed a wave of strange symptoms that have persisted to this day.

My symptoms:

• Severe fatigue and muscle weakness
• Burning in hands and feet
• Excessive weight gain
• Exercise intolerance ( my muscles literally shake and burn when I flex them. It feels like I just finished a 2 hour workout when I haven't done anything at all)
• Hot flashes and cold extremities
• Heart palpitations, especially after eating
• Severe gut dysfunction – tight, distended stomach and bloating
• No ability to sweat
• Extreme supplement sensitivity – even mild ones cause overstimulation or crashes
• Chronic anxiety and panic episodes
• Elevated inflammatory markers (TNF-alpha, Interleukins) and Candida IgE was elevated
• High insulin levels ( tried ozempic and mounjaro but feel awful taking them )
• Feel completely disconnected from my body, like my nervous system is broken

I’ve tried 100s of different supplements, some peptides, lifestyle changes, and seen both conventional and functional doctors, but nothing has fully resolved this. Oddly enough, when I tried pharmaceutical triptorelin much later with vitamin b5 and b6, some symptoms temporarily improved — like sweating, energy, and calm. I was also able to exercise — but once it wore off, things got worse again. I tried this because I thought maybe it would reset my hpta. It clearly didn't stick.

I've even gotten 2 colonoscopie due to the gut issues. My stool also isn't the same consistency as it was before the injection. It's paler and very messy now. Done 100s of other tests and gotten little to no answers. I had mild anxiety moments in the past but never anything serious until this. Now I'm taking 5mg of lexapro for it. I just seen a naturopath and they think that it's mold toxicity which I'm not to sure about but I'm open to trying anything at this point.


It feels like something in my neuroendocrine or gut-brain axis was deeply disrupted. All hormones are normal. Some providers think this may be a form of CIRS, neuroinflammation, or autonomic nervous system injury. Idk if the triptorelin was contaminated, or my body was already dealing with some weakness and the triptorelin was the straw the broke the camels back.



If anyone else has experienced something similar from triptorelin or other peptides, or if you’ve found anything that helped repair the damage, or doctors that I can see, I’d really appreciate hearing from you. I’m trying to stay hopeful and piece together answers. 6 years of my life wasted due to one injection.



Thank you.

 

[RonaldRt]

Triptorelin is a powerful GnRH agonist that can cause long-lasting changes in your hormonal axis, it can lead to prolonged dysregulation. Your symptoms point toward nervous system inflammation. The elevated inflammatory markers and Candida IgE you mentioned could mean your immune system is in a state of chronic activation. Have you tried vitamin B5 and B6 to help with systematic inflammation? I’m no doctor however and I would recommend an endocrinologist. Good luck

 

[flasspass123]

Triptorelin is a powerful GnRH agonist that can cause long-lasting changes in your hormonal axis, it can lead to prolonged dysregulation. Your symptoms point toward nervous system inflammation. The elevated inflammatory markers and Candida IgE you mentioned could mean your immune system is in a state of chronic activation. Have you tried vitamin B5 and B6 to help with systematic inflammation? I’m no doctor however and I would recommend an endocrinologist. Good luck

Thank you for the response and yes I have tried B5 and B6 when I tried the Pharma triptorelin. They stopped working once the pharma triptorelin left my system. I've spoken to other experts and they do agree that my symptoms point toward nervous system inflammation and chronic activation of the immune system. Working on that now. If anyone else has suggestions or input I'd highly appreciate it, thanks guys.

 

[eryximachus]

Try to get one of those $500 complete lab panels and post the results here.

I haven't read about triptorelin in a long while. Always seemed like snake oil to me. Some people have permanent, long-term changes due to the use of AAS - virtually everyone can recover with clomid. Desperate people used to post on these forums who claimed to never recover, and that was the go-to solution.

I don't mean to get you down, but those long term changes always sounded to me like emergent mental illness. But post your labs and let's see what's up.

 

[Luke391]

Hey guys, currently 29 years old. I was on gear, just testosterone from 2018-2019. PCTed during covid in 2020 with clomid, and took some letro as my e2 got high.

Things were going decent and I decided to take 100mcg of a non-pharmaceutical version of triptorelin to finish off the pct. After this injection my health has not been the same since. I developed a wave of strange symptoms that have persisted to this day.

My symptoms:

• Severe fatigue and muscle weakness
• Burning in hands and feet
• Excessive weight gain
• Exercise intolerance ( my muscles literally shake and burn when I flex them. It feels like I just finished a 2 hour workout when I haven't done anything at all)
• Hot flashes and cold extremities
• Heart palpitations, especially after eating
• Severe gut dysfunction – tight, distended stomach and bloating
• No ability to sweat
• Extreme supplement sensitivity – even mild ones cause overstimulation or crashes
• Chronic anxiety and panic episodes
• Elevated inflammatory markers (TNF-alpha, Interleukins) and Candida IgE was elevated
• High insulin levels ( tried ozempic and mounjaro but feel awful taking them )
• Feel completely disconnected from my body, like my nervous system is broken

I’ve tried 100s of different supplements, some peptides, lifestyle changes, and seen both conventional and functional doctors, but nothing has fully resolved this. Oddly enough, when I tried pharmaceutical triptorelin much later with vitamin b5 and b6, some symptoms temporarily improved — like sweating, energy, and calm. I was also able to exercise — but once it wore off, things got worse again. I tried this because I thought maybe it would reset my hpta. It clearly didn't stick.

I've even gotten 2 colonoscopie due to the gut issues. My stool also isn't the same consistency as it was before the injection. It's paler and very messy now. Done 100s of other tests and gotten little to no answers. I had mild anxiety moments in the past but never anything serious until this. Now I'm taking 5mg of lexapro for it. I just seen a naturopath and they think that it's mold toxicity which I'm not to sure about but I'm open to trying anything at this point.


It feels like something in my neuroendocrine or gut-brain axis was deeply disrupted. All hormones are normal. Some providers think this may be a form of CIRS, neuroinflammation, or autonomic nervous system injury. Idk if the triptorelin was contaminated, or my body was already dealing with some weakness and the triptorelin was the straw the broke the camels back.



If anyone else has experienced something similar from triptorelin or other peptides, or if you’ve found anything that helped repair the damage, or doctors that I can see, I’d really appreciate hearing from you. I’m trying to stay hopeful and piece together answers. 6 years of my life wasted due to one injection.



Thank you.

I have no experience with Triptorelin but
get a full panel blood work. talking full hormonal panel, lipids, liver markers, blood glucose, vitamins and minerals, thyroid, inflammation and oxidative stress markers and everything you can trow in.
If anything is off, take the safest, most "natural" way to fixing it. (example, if your thyroid's fucked, try iodine supplementation and cardio before going to t3 and t4)

Also, what streoids did you use? Some get fucked up mentally from using certain things, especially if you're already in a questionable state of mind.

My guess is that PCT wasn't proper ans your hormones are fucked. maybe low test, or maybe normal test with high SHBG, so super low free test. Maybe aromatize too much and have high estrogen.

Also, very important to look into brain health. you probably never used neurosteroids (pregnenolone and DHEA) which are important for proper brain function on cycle because when you HPTA shuts down their production is also significantly decreased. So maybe look to get on those (they're OTC supplements)

Get your gut microbiome checked and do an elimination diet to try and fix it. possibly use anti-fungal medications if you have Candida overgrowth.
Maybe even try fasting for multiple days if you are brave enough.
Even oral BPC157, TB500 and Metformin could be helpfull for your gut health.

Look into peptides that regulate immune system function like Thymosin Alpha1 and KPV.

try to figure out if any of you sympoms can be linked to life stressors and mental ilness. If so try therapy and maybe ansiolitics like Ashwaganda and Selank.
If it is mental ilness derived I know people had positive experinces with cerebrolysis. Saying it improved memory, brain plasticity, decreased impulsiveness and dopaminergic drive. The higher brain plasticity could also make any kind of therapy more effective.

Study Low Dose Naltrexone also. It seems very safe and used for a variety of health conditions. I'm thinking of trying it for chronic pain/"fibromyalgia" (in brackets because idk if it's bullshit or a real thing).
I can somewhat relate to the "exercise intolerance lol". some days I can go and train fine, others I go in the gym and for no reason at all everything feels impossibly heavy and I feel like every muscle in my body is burning as if I had done 50sets in one sitting. This pain/burning feeling in my whole body usually happens 1-2 times per month (with different severity) and puts me out of any phisical work for 2-4 days. Sometimes I can still struggle trough a mini workout, other times it gets so bad I can't do anything phisical for a few days. Been happening since I was 12-13yrs old. I call it fibromyalgia but we'll see. got bpc157 and tb500 to try for it now. I notice that if I'm fatter it's not as bad, and as I get leaner it gets progressivly worse.

High dose omega3 (especially high dose EPA) are miraculous for many people, going up to 3000mg of EPA per day can do wonders for chronic inflammation and immune system dysregulation.

Maybe try Methyele blue? kinda one of those things where some feel nothing on it, some (like me) get a good cognitive boost, and a few people get some very extreme responses, either positive or negative. I've heard of people giving it to their old family members who's mind was no longer there and seeing massive improvement. Others reporting panic attacks and all sorts of crap. but probably safe.

Megadose melatonin if you have trouble sleeping (10mg per night minimum). Poor REM sleep might explain many of your symtoms, so if you can get a sleep study on you done. (idk what they're called but when they take you in a clinic for like a week and tou sleep there hooked up to a bunch of machines to check what's up with your sleep)
Alchool and certain pharmaceuticals can reduce REM sleep, so make sure you don't take anything that can impact it.

Try to look at anecdotal evidence on C60 Fullerene also. There's not conclusive clinical evidence and I also don't know much about it but on reddit and other forums there are people talking about how it fixed them after they developed a bunch of health conditions from certain drugs/vaccines/surgeries

 

[AlexDavis43]

Megadose melatonin if you have trouble sleeping (10mg per night minimum). Poor REM sleep might explain many of your symtoms, so if you can get a sleep study on you done. (idk what they're called but when they take you in a clinic for like a week and tou sleep there hooked up to a bunch of machines to check what's up with your sleep)
Alchool and certain pharmaceuticals can reduce REM sleep, so make sure you don't take anything that can impact it.

If sleep is the problem, melatonin at any dose is not a great option

A great option: CBTi

Basics of CBTi from Mayo Clinic, Sleep Foundation, and Stanford Med

Pick one and read it. This is the best sleep advice you will ever receive.

 

[flasspass123]

Try to get one of those $500 complete lab panels and post the results here.

I haven't read about triptorelin in a long while. Always seemed like snake oil to me. Some people have permanent, long-term changes due to the use of AAS - virtually everyone can recover with clomid. Desperate people used to post on these forums who claimed to never recover, and that was the go-to solution.

I don't mean to get you down, but those long term changes always sounded to me like emergent mental illness. But post your labs and let's see what's up.

View: https://imgur.com/a/5EwWTpU



View: https://imgur.com/a/hqTJnEr


View: https://imgur.com/a/Eb4I4mL

 

[flasspass123]

Try to get one of those $500 complete lab panels and post the results here.

I haven't read about triptorelin in a long while. Always seemed like snake oil to me. Some people have permanent, long-term changes due to the use of AAS - virtually everyone can recover with clomid. Desperate people used to post on these forums who claimed to never recover, and that was the go-to solution.

I don't mean to get you down, but those long term changes always sounded to me like emergent mental illness. But post your labs and let's see what's up.

I have 100s of test results. I posted a bunch of them, please let me know what you think.

 

[Luke391]

View: https://imgur.com/a/5EwWTpU



View: https://imgur.com/a/hqTJnEr


View: https://imgur.com/a/Eb4I4mL

nothing super concernint but free test is low, HGH is low, zinc and vitamin A should be higher, iodine is low.
Clear intestinal bacteria overgrowth, look into anti-fungal medications and do an elimination diet (no grains, no dairy, no added sugar, no alchool) and ideally fasting.
Gut microbiome is so much more important that people think for overall well being (I'm guilty of this as well).
Creatinine is high. Probably a lot of inflammation. Try anti-inflammatory supplements (vitamin C, EPA, GlyNAC, Melatonin) and Astragalus root extract + more water and balanced electrolyte intake to support the kidneys. Maybe a cycle BPC+TB to support muscle recovery, since generally when the muscles are overworked/underrecovered creatinine increases.
Cortisol is a little high and Estradiol is low. Chill out and maybe try ansiolitics like Ashwaganda and Selank. Do a proper PCT or get back on TRT, only if you did everything you can to get your test up naturally (get leaner, good sleep, ice your balls, proper micronutrient intake) or try to lower your SHBG.

C reactive protein is high. Again, lots of inflammation. As I said look into anti-inflammatory supplements and peptides and do an elimination diet.

Thyroglobulin antibody is high, possibly indicating an autoimmune disease. Same shit, elimination diet and Immune system regulator peptides.

 

[eryximachus]

I'm going to go out on a limb and suggest TRT + an antidepressant like Lexapro. An SSRI should help with many of the symptoms and give you the energy to work out intensely and get your life back on track.

Try that for 6 months and come back to us.

Also - are these labs from 2021? If this has been an ongoing problem for 4+ years, then you absolutely need to see a psychiatrist.

 

[flasspass123]

I'm going to go out on a limb and suggest TRT + an antidepressant like Lexapro. An SSRI should help with many of the symptoms and give you the energy to work out intensely and get your life back on track.

Try that for 6 months and come back to us.

Also - are these labs from 2021? If this has been an ongoing problem for 4+ years, then you absolutely need to see a psychiatrist.

The last pic of the first link shows all of my testosterone results from this year. Im on lexapro 5mg for about 2 years now, it's helped a bit with my mental but Im still dealing with all of these crappy symptoms. Hot flashes, chronic fatigue, excessive weight gain, muscle weakness and an inability to exercise.

I've been trying to hold off on trt since my levels seem normal for the last 5 years but one of my last tests showed low free and bioavailable testosterone. This was done in March of this year.

 

[Luke391]

The last pic of the first link shows all of my testosterone results from this year. Im on lexapro 5mg for about 2 years now, it's helped a bit with my mental but Im still dealing with all of these crappy symptoms. Hot flashes, chronic fatigue, excessive weight gain, muscle weakness and an inability to exercise.

I've been trying to hold off on trt since my levels seem normal for the last 5 years but one of my last tests showed low free and bioavailable testosterone. This was done in March of this year.

have you tought about trying Low Dose Naltrexone for the chronic pain? Also mitochondrial peptides might help with the inability to excercise and excess bodyfat. Like Methylene blue, CoQ10, PQQ, L-Carnitine, NAD, Mot-C, SLU-PP322 and 5Amino1MQ

 

[Sera]

Hey guys, currently 29 years old. I was on gear, just testosterone from 2018-2019. PCTed during covid in 2020 with clomid, and took some letro as my e2 got high.

Things were going decent and I decided to take 100mcg of a non-pharmaceutical version of triptorelin to finish off the pct. After this injection my health has not been the same since. I developed a wave of strange symptoms that have persisted to this day.

My symptoms:

• Severe fatigue and muscle weakness
• Burning in hands and feet
• Excessive weight gain
• Exercise intolerance ( my muscles literally shake and burn when I flex them. It feels like I just finished a 2 hour workout when I haven't done anything at all)
• Hot flashes and cold extremities
• Heart palpitations, especially after eating
• Severe gut dysfunction – tight, distended stomach and bloating
• No ability to sweat
• Extreme supplement sensitivity – even mild ones cause overstimulation or crashes
• Chronic anxiety and panic episodes
• Elevated inflammatory markers (TNF-alpha, Interleukins) and Candida IgE was elevated
• High insulin levels ( tried ozempic and mounjaro but feel awful taking them )
• Feel completely disconnected from my body, like my nervous system is broken

I’ve tried 100s of different supplements, some peptides, lifestyle changes, and seen both conventional and functional doctors, but nothing has fully resolved this. Oddly enough, when I tried pharmaceutical triptorelin much later with vitamin b5 and b6, some symptoms temporarily improved — like sweating, energy, and calm. I was also able to exercise — but once it wore off, things got worse again. I tried this because I thought maybe it would reset my hpta. It clearly didn't stick.

I've even gotten 2 colonoscopie due to the gut issues. My stool also isn't the same consistency as it was before the injection. It's paler and very messy now. Done 100s of other tests and gotten little to no answers. I had mild anxiety moments in the past but never anything serious until this. Now I'm taking 5mg of lexapro for it. I just seen a naturopath and they think that it's mold toxicity which I'm not to sure about but I'm open to trying anything at this point.


It feels like something in my neuroendocrine or gut-brain axis was deeply disrupted. All hormones are normal. Some providers think this may be a form of CIRS, neuroinflammation, or autonomic nervous system injury. Idk if the triptorelin was contaminated, or my body was already dealing with some weakness and the triptorelin was the straw the broke the camels back.



If anyone else has experienced something similar from triptorelin or other peptides, or if you’ve found anything that helped repair the damage, or doctors that I can see, I’d really appreciate hearing from you. I’m trying to stay hopeful and piece together answers. 6 years of my life wasted due to one injection.



Thank you.

Sounds like long covid

 

[flasspass123]

Sounds like long covid

I suspected that. But I didn’t have Covid when this all started. I started feeling like shit right after the triptorelin injection, unless the vial had the virus in it lol.

 

[Sera]

I suspected that. But I didn’t have Covid when this all started. I started feeling like shit right after the triptorelin injection, unless the vial had the virus in it lol.

Might have activated your immune system or something

 

[flasspass123]

Might have activated your immune system or something

This is what a few people that I have spoken seem to think as well, but I haven’t but able to find any resolve. I tried several different supplements for the immune system, epicor, immunoglobulins, colostrum, etc. I seen an immunologist almost 2 years ago and he did a cytokine panel but he didn’t seem to think much of it. Just said there could be a chink in my immune system.

 

[flasspass123]

have you tought about trying Low Dose Naltrexone for the chronic pain? Also mitochondrial peptides might help with the inability to excercise and excess bodyfat. Like Methylene blue, CoQ10, PQQ, L-Carnitine, NAD, Mot-C, SLU-PP322 and 5Amino1MQ

I did try low dose naltrexone but to be honest I didn’t give it a full go. I gave up after a few doses. I need to actually try it some for time to see if it can help me. Thanks for the other recommendations, if you can rank them from order of effectiveness and priority for my situation how would you? Thank you in advance.

 

[eryximachus]

The last pic of the first link shows all of my testosterone results from this year. Im on lexapro 5mg for about 2 years now, it's helped a bit with my mental but Im still dealing with all of these crappy symptoms. Hot flashes, chronic fatigue, excessive weight gain, muscle weakness and an inability to exercise.

I've been trying to hold off on trt since my levels seem normal for the last 5 years but one of my last tests showed low free and bioavailable testosterone. This was done in March of this year.

Technically, SNRI drugs are better for psychosomatic pain but aren't as easily tolerated. Duloxetine is the most popular.

Lexapro 5mg is the minimum dose. I would suggest working with a psychiatrist - you shouldn't have been on 5mg for 2 years while experiencing these symptoms.

 

[flasspass123]

Technically, SNRI drugs are better for psychosomatic pain but aren't as easily tolerated. Duloxetine is the most popular.

Lexapro 5mg is the minimum dose. I would suggest working with a psychiatrist - you shouldn't have been on 5mg for 2 years while experiencing these symptoms.

I do have a psychiatrist, she thinks my physical symptoms are unrelated to mental and told me to work with my PCP on that end.

 

[flasspass123]

Technically, SNRI drugs are better for psychosomatic pain but aren't as easily tolerated. Duloxetine is the most popular.

Lexapro 5mg is the minimum dose. I would suggest working with a psychiatrist - you shouldn't have been on 5mg for 2 years while experiencing these symptoms.

Thanks for enlightening me though, I will ask her about duloxetine. I’m also going to ask my PCP about trt. I’m tired of living like this and just want my life back.