ARBs or ACE Inhibitors for HBP?

[BP_6]

My top BP drugs for enhanced athletes. This is manly taking BP control as the main factor. In my personal order of preference but all will work well

ARB's Telimasartan, Azilsartan, Olmesartan
Beta Blockers: Nebivolol
Calcium Channel blockers: Cilnidipine, Amlodipine
Thiazide diuretics: chlorthalidone, indapamide, hydrochlorothiazide

All work on different channels, so all 4 classes can technically be taken together.

 

[Sampei]

My top BP drugs for enhanced athletes. This is manly taking BP control as the main factor. In my personal order of preference but all will work well

ARB's Telimasartan, Azilsartan, Olmesartan
Beta Blockers: Nebivolol
Calcium Channel blockers: Cilnidipine, Amlodipine
Thiazide diuretics: chlorthalidone, indapamide, hydrochlorothiazide

All work on different channels, so all 4 classes can technically be taken together.

If one doesn't have access to cilnidipine, Lercanidipine is a much better alternative then Amlodipine

 

[BP_6]

If one doesn't have access to cilnidipine, Lercanidipine is a much better alternative then Amlodipine

Thanks for that info. i was unaware of this drug. I will look more into it.

 

[crtx]

If you decide to try a CCB in the future, use Cilnidipine. Newer generation that mostly fixes the edema issue. Has some other benefits as well vs the older generation.

appreciate the reply and advice mate i'm not really up to scratch with Calcium blockers etc..

 

[crtx]

My top BP drugs for enhanced athletes. This is manly taking BP control as the main factor. In my personal order of preference but all will work well

ARB's Telimasartan, Azilsartan, Olmesartan
Beta Blockers: Nebivolol
Calcium Channel blockers: Cilnidipine, Amlodipine
Thiazide diuretics: chlorthalidone, indapamide, hydrochlorothiazide

All work on different channels, so all 4 classes can technically be taken together.

noted!
Beta blockers works on lower heart rate? Nebivolo?

 

[Ghoul]

appreciate the reply and advice mate i'm not really up to scratch with Calcium blockers etc..

Cilnidipine is the shit.

It blocks sympathetic release of epinephrine from nerve ends. Not only does this keep BP in check, it prevents stress induced muscle tension, cramps, and Reynaud's symptoms (toes/fingers going numb randomly). You feel chilled out without sedation, because the mind/body stress feedback loop is interrupted.

 

[crtx]

Cilnidipine is the shit.

It blocks sympathetic release of epinephrine from nerve ends. Not only does this keep BP in check, it prevents stress induced muscle tension, cramps, and Reynaud's symptoms (toes/fingers going numb randomly). You feel chilled out without sedation, because the mind/body stress feedback loop is interrupted.

This tingles i was getting also is that what they call it Reynaud's symptom. couldn't figure it out but on hgh also.

 

[PrizonMike]

i was on teli 80/12.5 wasn't doing the job quite well 160-170/90-100 in afternoon on cycle managing my BP. doc changed it Reaptan 5 mg/10 mg (perindopril arginine/amlodipine. got my bp 150-95 not great. then
disaster.... 8kg edema from being on this 1 week. ended up getting DVT right calf clot and one on the lung induced heavy breathing. now on thinners next 6months cause one fucking change.

back on teli 80/25 waters gone. bp 130/75 still on cycle afternoon.

Culprit was amlodipine 10mg. will never touch that drug again body said big NO.

Edema can creep up fast with amlodipine

 

[Ghoul]

Edema can creep up fast with amlodipine

Amlodipine should be ditched if you can get Cilnidipine. Amlodipine accelerates developing edema or worsens existing edema in an irreversible way, vs Cilnidipine which prevents this, and has a bunch of other positive health effects, particularly if you have high adregenic tone, ie, your BP goes up and/or muscles tighten with psychological stress.

 

[crtx]

Edema can creep up fast with amlodipine

Yep bloody disaster all good now. teli 80/25 130/65-70

 

[FR384]

I chose Telmisartan from Derek/more plates more dates' information, I just cant get my doctor to prescribe it, so was buying from China. Its a pain in the ass to get consistently

I think a few sources have Telmisartan raw powder still, buy 500grms and make your own capsules up for life.

Also, I noticed you mentioned NAC. Check out NACET, much more bioavailable.

 

[Ghoul]

I think a few sources have Telmisartan raw powder still, buy 500grms and make your own capsules up for life.

Also, I noticed you mentioned NAC. Check out NACET, much more bioavailable.

Telm is not very soluble, and every tablet formulation contains excipients (like Sodium Hydroxide or Meglumine) to ensure it dissolves and reaches ~50% bioavailability.

It also degrades rapidly when exposed to air and humidity.

A powder is going to lose potency fast, and the amount you actually absorb will be much lower along with a lot of variability,

Telm tabs are very cheap from India pharma when you buy a few hundred at a time. Under 8¢ a tablet for 80mg, and come in all aluminum blisters to prevent them from degrading,

 

[FR384]

Telm is not very soluble, and every tablet formulation contains excipients (like Sodium Hydroxide or Meglumine) to ensure it dissolves and reaches ~50% bioavailability.

It also degrades rapidly when exposed to air and humidity.

A powder is going to lose potency fast, and the amount you actually absorb will be much lower along with a lot of variability,

Telm tabs are very cheap from India pharma when you buy a few hundred at a time. Under 8¢ a tablet for 80mg, and come in all aluminum blisters to prevent them from degrading,

I didn't know that about the Telm! Thanks for the heads up!

Good to see you mate, lost login and forgot what email I used to sign up to my old account - BrokenOne. How's things been? I recovered my heart failure from 30% to 60% (Normal range) and hearts back to very close to normal size.

 

[explodingHeart]

Telm is not very soluble, and every tablet formulation contains excipients (like Sodium Hydroxide or Meglumine) to ensure it dissolves and reaches ~50% bioavailability.

It also degrades rapidly when exposed to air and humidity.

A powder is going to lose potency fast, and the amount you actually absorb will be much lower along with a lot of variability,

Telm tabs are very cheap from India pharma when you buy a few hundred at a time. Under 8¢ a tablet for 80mg, and come in all aluminum blisters to prevent them from degrading,

I was one of the retards who bought 50g of powdered telm from QSC. Is it totally worthless?

 

[Ghoul]

I didn't know that about the Telm! Thanks for the heads up!

Good to see you mate, lost login and forgot what email I used to sign up to my old account - BrokenOne. How's things been? I recovered my heart failure from 30% to 60% (Normal range) and hearts back to very close to normal size.

Glad to see you too!

And just to be clear, this isn't general "don't expose pharmaceuticals to air/light/heat/humidity. Telm is uniquely quick degrading. My curiosity was peaked when my pharmacist pointed out why I was getting three small manufacturer's sealed bottles of 30 vs the usual 90 tablets dispensed from bulk containers into a standard pharmacy bottle like other meds. I noticed each manufacturer's bottle had a warning about not putting tabs into pill organizers, along with a moisture absorber / oxygen eater canister.

Then my next fill was from another pharmacy that didn't do this, and I realized they were mishandling it.

Ultimately India pharm was cheaper, more convenient, and in blister packs you know each tablet will maintain full potency. Important for a maintenance med you're taking long term. If BP starts creeping up, you may start chasing other causes, or worse, change doses or meds, when it's simply degraded tablets.

https://www.mdpi.com/1999-4923/14/8/1667

 

[Ghoul]

I was one of the retards who bought 50g of powdered telm from QSC. Is it totally worthless?

It doesn't degrade into toxic compounds, probobly has some activity left depending on storage conditions (powder has a lot of exposed surface area making it exceptionally vulnerable) but mainly why play roulette with your BP when you could easily get pharma grade Telm for $20-$30 for a year's supply?

It's hard enough to dial in the right dose of BP meds, I wouldn't want to complicate it with mystery powder, my ability to measure it properly, and end up being dizzy from driving myself into hypotension.

Nobody wants to waste anything they've paid for, but when we're talking about health, the least expensive step to take is throwing away your mistake.

Consider it tuition for your self managed medical care education .

I reluctantly chucked 5 years worth of telm/amlodipine tabs when I realized amlodipine was likely to lead to compression socks in a few years, lol.

 

[explodingHeart]

why play roulette with your BP when you could easily get pharma grade Telm for $20-$30 for a year's supply?

Your'e right. That's a good point.

Did you get my PM about kidney safe NSAIDS? (probably nothing exists and a dumb question but I was desperate)

 

[Ghoul]

Your'e right. That's a good point.

Did you get my PM about kidney safe NSAIDS? (probably nothing exists and a dumb question but I was desperate)

Sorry I'm backed up on dms, but I know this one anyway. It's sulindac, which is completely inactive in the kidneys.

But like you said, there really is no safe NSAID, and with sulindac the biggest risk from long term use is tearing up your stomach more than other NSAIDS. Short term is fine, but daily for months requires use of things that lower stomach acid, PPIs are usually prescribed.

I'm sure you know this, but it's much better to get to the bottom of the inflammation and resolve it than live on NSAIDs.

 

[explodingHeart]

worsens existing edema in an irreversible way

Wait what? How?