Minimum Nandrolone dose before neurotoxicity

Curious if that converts into DHN more easily, since transdermal testosterone results in higher levels of DHT
Not sure bro… I’m already bald as an aircraft carrier runway … and my back is like Chewbacca on Juice… I was taking Test and DHB via Topical and 50-100mg Proviron for 5-6 months … it was awesome … definitely tanked my E2 though
 
Total T was 1700. Ive since switched to injectable. I use the leftover cream as a preworkout

What was the transdermal base dosed at? and how would you compare it to an injectable dosing?

Ive got versapenn transdermal base on hand, was going to use it for TNE PWO but changed my mind because i think the absorption rate is really low..~20-40%?
 
@malfeasance

If we dismiss the initial study because of the physiological androgen variance then wouldn’t the second study be moot also?

I understand nandrolone and GH work on different receptors/pathways, but regardless, the studies still pertains directly to the hypothalamus. I Googled IGF receptors of rats vs humans and found they are very similar, but different due to “species specific mechanisms”. How different? No clue.

Anyway, is it reasonable to extrapolate that deleterious effects of nandrolone could be offset via a GH regiment? I’m sure many will utilize the study as justification for using the compounds whether it’s reasonable or not
 
What was the transdermal base dosed at? and how would you compare it to an injectable dosing?

Ive got versapenn transdermal base on hand, was going to use it for TNE PWO but changed my mind because i think the absorption rate is really low..~20-40%?
At the time of the bloods the dosage I was taking was 100 mg twice daily. The labs were drawn 5 hours after applying (per doc's instructions). I had not used a cream before and was very skeptical but the doc told me that 95+% of his patients preferred the cream over the injections due to convenience. It's apparently a very high potency compounded cream, and the numbers didn't lie.

Interestingly, when I was first titrating the dosage, my total T was only 750 or so on the 100 mg applied twice daily. The doc asked me how i was feeling and I said better than baseline (test was under 300 prior to starting HRT), but still room for improvement. So be bumped me up to 150 mg twice daily and on that dosage my Total T was 2200 (didn't test DHT at that time). So I backed off on that since my E2 was 100 (though i didn't have any discernible E2 sides).

As far as how I would compare it, I don't "feel" any different really, though on paper my blood levels are more stable. I will be getting another round of bloodwork in 4-6 weeks after I phase out the cream and reach a steady state on my Test / Primo combo.
 
What was the transdermal base dosed at? and how would you compare it to an injectable dosing?

Ive got versapenn transdermal base on hand, was going to use it for TNE PWO but changed my mind because i think the absorption rate is really low..~20-40%?
How do you like Versapenn compared to other topical carriers ( Phlojel Ultra , Iron Legion Salvo,etc)
 
Apologies for hijacking lol. i shall not reply further

How do you like Versapenn compared to other topical carriers ( Phlojel Ultra , Iron Legion Salvo,etc)

I have not used it, after finding out the absorption rate is so low. I'd need 500mg+ of TNE just for 100mg injection. Look below

At the time of the bloods the dosage I was taking was 100 mg twice daily. The labs were drawn 5 hours after applying (per doc's instructions). I had not used a cream before and was very skeptical but the doc told me that 95+% of his patients preferred the cream over the injections due to convenience. It's apparently a very high potency compounded cream, and the numbers didn't lie.

Interestingly, when I was first titrating the dosage, my total T was only 750 or so on the 100 mg applied twice daily. The doc asked me how i was feeling and I said better than baseline (test was under 300 prior to starting HRT), but still room for improvement. So be bumped me up to 150 mg twice daily and on that dosage my Total T was 2200 (didn't test DHT at that time). So I backed off on that since my E2 was 100 (though i didn't have any discernible E2 sides).

As far as how I would compare it, I don't "feel" any different really, though on paper my blood levels are more stable. I will be getting another round of bloodwork in 4-6 weeks after I phase out the cream and reach a steady state on my Test / Primo combo.

So 150 2x a day was 2200.
Per below, Dirthand was at 7000+ after a 100TNE shot.

So to get the same T, i'd reckon you need 150x4=600
Which puts the absorption rate slightly below 20% for transdermal vs inj :/

 
Apologies for hijacking lol. i shall not reply further



I have not used it, after finding out the absorbtion rate is so low. I'd need 300-400mg of TNE just for 100mg injection.



So 150 2x a day was 2200.
Per below, Dirthand was at 7000+ after a 100TNE shot.

So to get the same T, i'd reckon you need 150x4=600
Which puts the absorption rate slightly below 20% for transdermal vs inj :/

Yup - it's not ideal - hence why i switched - it's also a bit messy.
 
Rocky did you have left over residue on your skin at all? When I used iron legion salvo… it was alcohol based .. nothing would be left over .. but with Phlojel at 100mg/ml … still noticed a leftover residue
 
Rocky did you have left over residue on your skin at all? When I used iron legion salvo… it was alcohol based .. nothing would be left over .. but with Phlojel at 100mg/ml … still noticed a leftover residue
Yes that was another drawback - residue on skin and clothing.
 
@malfeasance

If we dismiss the initial study because of the physiological androgen variance then wouldn’t the second study be moot also?

I understand nandrolone and GH work on different receptors/pathways, but regardless, the studies still pertains directly to the hypothalamus. I Googled IGF receptors of rats vs humans and found they are very similar, but different due to “species specific mechanisms”. How different? No clue.

Anyway, is it reasonable to extrapolate that deleterious effects of nandrolone could be offset via a GH regiment? I’m sure many will utilize the study as justification for using the compounds whether it’s reasonable or not
Yeah, I am not dismissing it.

I do not even know if there is a difference in androgen receptors in that area o the brain.

It is a question.

It may be reasonable to extrapolate those results to me, but it may not. I simply do not have enough information from that study to conclude that I am going to be a drooling idiot early in life because Deca gave me muscles.
 
Me either. When starting the journey I assumed there would be more definitive answers than I’ve found so far. Especially regarding test, nandrolone, and gh since they are used medicinally.
If I'm not mistaken, I believe the exact mechanism of action of acetaminophen is also not clearly / totally understood.
 
If I'm not mistaken, I believe the exact mechanism of action of acetaminophen is also not clearly / totally understood.
I get it. It always boils down to risk v. reward. Especially when the compounds aren’t essential to wellness and health in the way we are utilizing them.
 
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