RockyP
Member
Are you a super heavy? That’s a lot of GH.
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dick_starbuck
Member
Not really. I used to think that until I read the serostim dosages for HIV patients.
Now @Ghoul will tell me that im going to have gigantism or signs of acromegaly soon.
RockyP
Member
Those HIV patients have a physiological process ongoing in their bodies that is intensely catabolic and sarcopenic. Extrapolating mg/kg dosing from that patient population is a big mistake.
dick_starbuck
Member
Cool story bro.
Im going to still use the efficacious dosage of GH and get some sick gainz at the cost of my longevity.
Really appreciate you on here.
Link to two posts with dose response curves based on pharma clinical trials. Hope it helps someone with dosing strategy.
Ghoul
Member
Not soon. Adult onset acromegaly usually has an 8 year delay. It's very slow and insidious. Individuals and families just assume they're gradually getting ugly with age. It's very hard to notice (and there's self delusion refusing to acknowledge it's happening).
A common story is that a family will be looking at pics of you a few years old. and notice how fast you've gone downhill.
Remember the signs and symptoms in this article, pass it on to your partner and kids, so you or someone else can catch it before your only future is as a Russian mob enforcer or circus freak:
Acromegaly: Are You Missing the Signs?
For patients with acromegaly, 10 years or more may pass from symptom onset before a correct diagnosis is made, by which time complications may already exist. Could you be missing the signs?
www.medscape.com
fit2beking
New Member
What’s a reasonable long term dose that could be used so that you dont start to look like Andre the giant?!Not soon. Adult onset acromegaly usually has an 8 year delay. It's very slow and insidious. Individuals and families just assume they're gradually getting ugly with age. It's very hard to notice (and there's self delusion refusing to acknowledge it's happening).
View attachment 341330
A common story is that a family will be looking at pics of you a few years old. and notice how fast you've gone downhill.
View attachment 341332
Remember the signs and symptoms in this article, pass it on to your partner and kids, so you or someone else can catch it before your only future is as a Russian mob enforcer or circus freak:
View attachment 341331
Acromegaly: Are You Missing the Signs?
For patients with acromegaly, 10 years or more may pass from symptom onset before a correct diagnosis is made, by which time complications may already exist. Could you be missing the signs?
dick_starbuck
Member
Getting ugly with age? Oh man, you had me worried. I've been ugly my whole life. Nothing to worry about then!Not soon. Adult onset acromegaly usually has an 8 year delay. It's very slow and insidious. Individuals and families just assume they're gradually getting ugly with age. It's very hard to notice (and there's self delusion refusing to acknowledge it's happening).
View attachment 341330
A common story is that a family will be looking at pics of you a few years old. and notice how fast you've gone downhill.
View attachment 341332
Remember the signs and symptoms in this article, pass it on to your partner and kids, so you or someone else can catch it before your only future is as a Russian mob enforcer or circus freak:
View attachment 341331
Acromegaly: Are You Missing the Signs?
For patients with acromegaly, 10 years or more may pass from symptom onset before a correct diagnosis is made, by which time complications may already exist. Could you be missing the signs?
Dose response curves:
IGF-1 reference ranges:
Reference Intervals for Insulin-like Growth Factor-1 (IGF-I) From Birth to Senescence: Results From a Multicenter Study Using a New Automated Chemiluminescence IGF-I Immunoassay Conforming to Recent International Recommendations
Context:. Measurement of IGF-I is a cornerstone in diagnosis and monitoring of GH-related diseases, but considerable discrepancies exist between analytical
academic.oup.com
FIG. 2
Individual points and fitted percentiles for males (right side) and females (left side). Displayed are the 2.5%, 25%, 50%, 75%, and 97.5% percentiles calculated by quantile regression via vector generalized additive models (LMS VGAM method).
Gory details: see supplemental data (link in paper)
pewex
Member
Example of acromegaly can be seen in "Big Paul' He shows all features of acromegaly. You can see the gradual physical changes unfolding before our eyes, every video of his he looks more and more like a caveman.Not soon. Adult onset acromegaly usually has an 8 year delay. It's very slow and insidious. Individuals and families just assume they're gradually getting ugly with age. It's very hard to notice (and there's self delusion refusing to acknowledge it's happening).
View attachment 341330
A common story is that a family will be looking at pics of you a few years old. and notice how fast you've gone downhill.
View attachment 341332
Remember the signs and symptoms in this article, pass it on to your partner and kids, so you or someone else can catch it before your only future is as a Russian mob enforcer or circus freak:
View attachment 341331
Acromegaly: Are You Missing the Signs?
For patients with acromegaly, 10 years or more may pass from symptom onset before a correct diagnosis is made, by which time complications may already exist. Could you be missing the signs?
Ateam2023
Member
he needs to quit shaving his eyebrows, he looks like an alien when he does that shit, ,
dick_starbuck
Member
Im pretty sure that dude is like 60 though. He may really well just be getting uglier with age.
dinfar1337
New Member
damn right
i dont believe acromangely is in my genetics. may it bless somebody else
pewex
Member
Aging isn't helping, but those facial changes are classic signs of acromegaly.
He's got a vacuum cleaner nose, a mouth like a garage door, a tongue thick as a steak, and a forehead big enough to double as a sun visor.
Ghoul
Member
Rule of thumb is as long as you're below 1.5x upper limit of the normal IGF-1 range, you can probably stay there indefinately without developing acromegalic features. So this is for those planning on staying on forever. The higher you go beyond 1.5x, the less time there is before acromegalic changes occur. How long? No one can say for sure. I've read one example that showed a case where @ 2x IGF ULN noticeable changes took about 2 years.
And sorry, no, there are no studies intentionally injecting healthy bodybuilders with supra-physiologic doses until they develop the disease. We have to make our best guess from the available data. So far all we've seen are a handful of celebrities and athletes suspected of developing it, who'll never admit rHGH use. Until recently, running high doses daily for years was out of the question for anyone but the very wealthy.
fit2beking
New Member
Based on your chart and my age range I am good. I do plan to stay on it long term just like I plan to stay on tirz long term as well. Good stuff here @Ghoul
Oh and Sylvester Stallone looks ugly af. He definitely has it. Lol
Ghoul
Member
Tirz and Reta seem like great companions to run with rHGH to increase the margin of safety against insulin resistance.
Those drugs are essentially incretin hormone replacements, and like TRT or insulin, intended to be taken for lifetime. Eli and Lily have done a good job of hiding this from most people. But from what we know after 30 years of GLP use, staying on a maintainance dose only lengthens lifespan and cuts the risk of countless diseases down significantly, far more than what weight loss alone accounts for.
fit2beking
New Member
I can certainly say that tirz has had a positive impact on quite a few things to include inflammation, blood pressure, BG and probably other stuff I’m forgetting to mention. I’m taking 40mg telmisartan daily and 5mg nebividol and my blood pressure averages 110-117/60-mid 70’s sometimes it will hit 80 while currently blasting. I believe the tirz is helping with keeping it low. Your thoughts on maybe dropping the telmisartan down to 20mg?
Ghoul
Member
You're in the ideal range that aligns with the best long term outcomes (a little too high on blast, but that's only short term exposure). And this is probobly the best documented health marker -> long term health data we have. Studies involving monitoring the records of millions, over a period of 50 years,
I wouldn't change it. Telm is already the "healthiest" BP med for long term use. Even boosts insulin sensitivity.
Blood sugar is controlled with a GLP.
The only other low hanging fruit for long term health is lipids. You want LDL below 60, stopping plaque accumulation. Below 55 it begins to reverse. The rest will sort of take care of itself, except Lp(a), a significant risk factor which is genetic and we can't do anything about yet, but meds are coming soon. May even be a once in a lifetime dose to knock it down permanently.
RockyP
Member
Lots of great scientific info in this thread. Here's some bro-science / anecdotal info:
This guy runs 10 iu (or at least he was for his most recent prep):
For this guy, 6 iu is his "sweet spot" (recent interview):
Kevin Levrone only ran GH very briefly during his career as he did not like the "watery" look it gave him:
This guy runs 10 iu (or at least he was for his most recent prep):
For this guy, 6 iu is his "sweet spot" (recent interview):
Kevin Levrone only ran GH very briefly during his career as he did not like the "watery" look it gave him:
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