Reta vs Tirz

[seelos]

Hey all, I'm very new to this community and I was wondering if anyone could provide some clarification on these two weight loss drugs.

When I first discovered retatrutide it sounded way too good to be true, but after further research it seems to do exactly what it claims with minimal sides (sensitive skin is the only one I've found). However, it seems that most of the experienced people on here still only discuss tirz as the best option.

I am aware that the appetite suppression effects of reta is overall weaker compared to other weight loss drugs, but ever since I did a couple aggressive mini cuts I haven't really had much trouble with not eating. Is the tirz preference just because most people need more appetite suppression, or is there something else that I'm missing?

I'm waiting on a shipment of reta so I can share my experience soon enough.

 

[Dirthand]

You could start at the bottom but you certainly don't have to, and if you do, I'd expect a major appetite rebound within a couple of weeks. In fact I'd say rebound is the bigger risk than too much appetite
suppression for you, as a long term stable Tirz user.

People on pharma are switched from Sema to Tirz all the time, and while there's no official guidance, the same philosophy is followed (slightly lower on Tirz dose level because Tirz maxes out at higher weight loss, so level 4 on Sema, 1mg, would be level 3 on Tirz, 7.5).

Tirz 7.5 is 3rd level (2.5-5-7.5-10-12.5-15). Reta is 1,2,4,8,12 (1 may be eliminated when it goes to market).

Based on this, you could conservatively start at 4. If a week later you're getting strong appetite rebound, I'd go to 6 (not an "official dose"), or just straight to 8, which is what pharma patients using fixed dose pens will be doing when they move up from 4, so you know 4 to 8 isn't the type of jump that's going to cause significant problems if 4 is tolerable.

Well, I was asking for my girl.. lol she been watching to much TikTok.. she just told me reta is stronger so she gonna start at 2.... I told her that sounded fucking amazing!!! Lol

 

[Lodi1brad]

Hey all, I'm very new to this community and I was wondering if anyone could provide some clarification on these two weight loss drugs.

When I first discovered retatrutide it sounded way too good to be true, but after further research it seems to do exactly what it claims with minimal sides (sensitive skin is the only one I've found). However, it seems that most of the experienced people on here still only discuss tirz as the best option.

I am aware that the appetite suppression effects of reta is overall weaker compared to other weight loss drugs, but ever since I did a couple aggressive mini cuts I haven't really had much trouble with not eating. Is the tirz preference just because most people need more appetite suppression, or is there something else that I'm missing?

I'm waiting on a shipment of reta so I can share my experience soon enough.

I just finished week 3 of Reta. Did 2 gms weekly for the first two weeks and bumped up to 3.5 for week 3. It’s absolutely works as advertised ans I’ve had zero side effects.

 

[KOArtist]

I’m a daily microdoser on my GLP’s, I pin Tirz on gh days (MWF) and Reta on the others

 

[Avies48]

I’m a daily microdoser on my GLP’s, I pin Tirz on gh days (MWF) and Reta on the others

Im afraid is die… my glucose would be so low i might actually die… and then no food from all that appetite suppression id be a looken like i was in a camp…

How does it affect ur blood glucose using all three items?

My wife had a horrible time on tirz… puking every week for months after she quit…

 

[Sera]

Cool thanks for clarifying, I know someone who was wanting to go the reta route but she was thinking she would start reta at 2 after being on triz at 7.5 triz. In actuality she would probably need to start reta at 6 if I understand correctly.
Thanks doll

Definitely don’t start at 6mg reta. Will make the resting heart rate go insane. 2mg maximum starting dose for 4 weeks and assess from there.

 

[Proud Pangolin]

Reta seems to be GLP that provides the ancillary benefits at doses that don't induce much appetite suppression for most. The unofficial "bodybuilder's GLP".

The question is what dosage?

 

[BamaCrazy]

The question is what dosage?

Different for everyone. 6mg was my sweet spot. I’m back up to 4mg now but I’m not getting the blood glucose benefits I’m looking for yet.

 

[Ghoul]

The question is what dosage?

It's going to vary widely.

Everyone produces a different baseline level of GLP hormone. and has a different level of GLP sensitivity.

If your production and sensitivity are on the high side, a small dose may cause too much appetite suppression. If you're a low producer and / or GLP insensitive, you may take 10mg without significant appetite suppression.

 

[RockyP]

Nothing proven, and I don't think it should be considered unless the max dose of a single compound proves insufficient. Even then, Sema and Tirz have increased doses(for poor responders) on the verge of approval, and are demonstrated safe. Up to 25mg Tirz and incredibly, 7.2mg sema. So there's more room for those compounds to be increased.

If someone feels like they must use an add on to Tirz or Reta, imo a tiny dose of Sema is the best route.

This way you're only boosting GLP agonism, the main appetite suppression mechanism, and not competing for GIP receptors against Reta or Tirz. GIP agonism varies greatly between these compounds. I wouldn't want to block a GIP receptor with Tirz, which replicates natural binding strength, from Reta which is 8x stronger when the difference is likely an important part of the "balance" in each of those compound's formula. .

My word. 25 of Tirz. I can barely get 2500 cals down on 5 mg. Nice to know the sky is the limit.

 

[tree_respecter]

4mg weekly of reta put me in full control of my eating habits and I was practically melting bf. Lots of people spend time combining drugs to try and elicit a really specific response, and it's true that everyone's mileage may vary, but data and anecdote seems to support that if you get into a clinically supported range on any one of that drug family, you're gonna get results.

I appreciate reta for allowing me to still hit macros. I had to work for it, but I liked that better than working harder just not to go over.

It seems tirz has a more subjective experience of craving suppression according to the community. In my n=1 experiment, I can confirm that on reta even the occasional slice of pizza or doughnut could not possibly hope to slow my weightloss down haha.

Tirz is cheaper on average and has a phenomenal body of research. Reta isn't on market yet, costs more, and the research is still catching up, but for what it's worth, I've absolutely loved it and recommend at least giving it a shot. Especially if you lift and plan your eating.

 

[Ghoul]

My word. 25 of Tirz. I can barely get 2500 cals down on 5 mg. Nice to know the sky is the limit.

I've been on 15mg pharma tirz for nearly 2 years. My level of appetite just feels "normal", without any active suppression. I eat a reasonable portion, and feel full. Never any GI effects.

This is what happens when your actual and GLP modified homeostasis weight align.

It's only when your actual weight is higher than whatever the homeostasis weight is "set" to by the dose of the GLP that there are side effects and crushing suppression. Once they align that stops. Extended multi year trials all demonstrate this is how these hormones work.

Unfortunately, so many people jump around from GLP to GLP, keep changing protocols, thinking they've developed a "tolerance", to the equivalent of a "diet pill" they never get to maintenance stage. There may even be unappreciated negative consequences from fucking around so much, especially given the unknown ways UGL produced GLPs may differentiate from pharma produced.

One big advantage of pharma is it forces the patient to use a steady protocol on a single GLP because of the fixed dose pens, and I think as a group reach their goal and maintain it with a higher level of success,

 

[Liter O' Test]

My word. 25 of Tirz. I can barely get 2500 cals down on 5 mg. Nice to know the sky is the limit.

how long have you been on 5mg?

 

[RockyP]

how long have you been on 5mg?

2 weeks. Starting to get some nausea / malaise first 24-48 hours after shots (splitting twice per week). Doc already wrote me for 7.5 dosage

 

[Ghoul]

2 weeks. Starting to get some nausea / malaise first 24-48 hours after shots (splitting twice per week). Doc already wrote me for 7.5 dosage

That's expected since the pharmacodynamics of GLPs mean blood levels don't plateau until after 4 weeks of steady doses, But they do nearly peak at 2, so I always advise people wait until that point to decide if a dose is sufficient. Week 1 can be very deceptive and fool you into thinking it's not enough.

 

[Liter O' Test]

2 weeks. Starting to get some nausea / malaise first 24-48 hours after shots (splitting twice per week). Doc already wrote me for 7.5 dosage

did you go right from 2.5mg to 5mg?
im planning on going from 2.5mg to 3mg then 3.5mg etc so i avoid this, i still need to eat atleast 3k a day.

 

[RockyP]

did you go right from 2.5mg to 5mg?
im planning on going from 2.5mg to 3mg then 3.5mg etc so i avoid this, i still need to eat atleast 3k a day.

Yes I’m doing the standard Lilly protocol as I’m taking pharma from the doc. Towards the end of 2.5 I was able to get closer to 3000 cals but after 1 week on 5 mg the appetite is back down. It’s not horrible. I can hit my macros. But it just takes some work

 

[RockyP]

That's expected since the pharmacodynamics of GLPs mean blood levels don't plateau until after 4 weeks of steady doses, But they do nearly peak at 2, so I always advise people wait until that point to decide if a dose is sufficient. Week 1 can be very deceptive and fool you into thinking it's not enough.

Thank you. This is in line with that I’ve noticed. I’m cutting so this is all welcomed effects. I have had to drop protein per meal down a little and increase carbs to keep appetite going

 

[eryximachus]

That's not what the facts show. 90%+ of people who successfully lose 10% + weight by traditional diets regain it within 5 years. They had the self control to pursue and achieve the loss by calorie restriction but an appetite that's malfunctioning and demanding excess calories can be as potent as a heroin or nicotine addiction. Most people will succumb to the pressure of an abundant food environment when they can't dedicate all their attention to battling an unrelenting appetite.

I hear a lot of anger toward GLPs from people who've been conditioned to think their properly functioning, or weak appetite, where their parents had to force their scrawny asses to eat, is some kind of superpower. There's a reason some people have to seek out appetite stimulants to be able to eat enough to put on gains.

This is an old post.

Many years ago in the early 2000s I did significant research on eating behavior and food additives. What I concluded is thus:

There are three major classes of addictive chemicals in food that cause people to overeat:

1) Gluten primarily from wheat. It is decomposed into morphine-like peptides that are in some cases stronger than morphine itself so far as the mu opioid receptors. Gluten is chemically modified in labs to be used as flavor enhancing agents. It becomes stronger and more difficult for your body to break down.

2) Casein from dairy products. Casein is also decomposed into morphine peptides, and it is probable that the behavioral effects of morphine originate from this. The "addiction" facilitates the mother-baby bonding relationship. Casein is very commonly chemically modified to be stronger and more difficult for your body to break down. You'll notice most "junk food" has "milk" listed as an ingredient.

3) Beta carbolines, which can be formed randomly from heating organic living things, also can be manufactured. Several interfere with dopamine reuptake like cocaine and are added to "junk food" and "ultra processed food" as flavor enhancers.

I noticed that no one overeats on say, strawberries or apples. they overeat on pizza and ice cream and potato chips. Living in NYC at the tie, I also noticed how all the pizza parlors had their kitchens near the front of the store and vented the ovens onto the street. The smell of pizza is VERY activating - it is clearly very addictive.

GLP-1 drugs appear to have a role in psychiatry and combat other forms of addiction, including alcohol and cocaine addiction.

So it really depends on the person. For some people, maybe Sema is the best because it has the strongest effect on these receptors and crosses the blood brain barrier.

Many people can just take control of their diet. Avoid wheat and dairy products. Avoid restaurants. Prepare only fresh organic produce and meat yourself.

 

[ineffectual]

This is an old post.

Many years ago in the early 2000s I did significant research on eating behavior and food additives. What I concluded is thus:

There are three major classes of addictive chemicals in food that cause people to overeat:

1) Gluten primarily from wheat. It is decomposed into morphine-like peptides that are in some cases stronger than morphine itself so far as the mu opioid receptors. Gluten is chemically modified in labs to be used as flavor enhancing agents. It becomes stronger and more difficult for your body to break down.

2) Casein from dairy products. Casein is also decomposed into morphine peptides, and it is probable that the behavioral effects of morphine originate from this. The "addiction" facilitates the mother-baby bonding relationship. Casein is very commonly chemically modified to be stronger and more difficult for your body to break down. You'll notice most "junk food" has "milk" listed as an ingredient.

3) Beta carbolines, which can be formed randomly from heating organic living things, also can be manufactured. Several interfere with dopamine reuptake like cocaine and are added to "junk food" and "ultra processed food" as flavor enhancers.

I noticed that no one overeats on say, strawberries or apples. they overeat on pizza and ice cream and potato chips. Living in NYC at the tie, I also noticed how all the pizza parlors had their kitchens near the front of the store and vented the ovens onto the street. The smell of pizza is VERY activating - it is clearly very addictive.

GLP-1 drugs appear to have a role in psychiatry and combat other forms of addiction, including alcohol and cocaine addiction.

So it really depends on the person. For some people, maybe Sema is the best because it has the strongest effect on these receptors and crosses the blood brain barrier.

Many people can just take control of their diet. Avoid wheat and dairy products. Avoid restaurants. Prepare only fresh organic produce and meat yourself.

Would explain my lust for all things cheeze.

 

[KOArtist]

Would explain my lust for all things cheeze.

Ain’t no such thing as too much cheese