Reta vs Tirz

[seelos]

Hey all, I'm very new to this community and I was wondering if anyone could provide some clarification on these two weight loss drugs.

When I first discovered retatrutide it sounded way too good to be true, but after further research it seems to do exactly what it claims with minimal sides (sensitive skin is the only one I've found). However, it seems that most of the experienced people on here still only discuss tirz as the best option.

I am aware that the appetite suppression effects of reta is overall weaker compared to other weight loss drugs, but ever since I did a couple aggressive mini cuts I haven't really had much trouble with not eating. Is the tirz preference just because most people need more appetite suppression, or is there something else that I'm missing?

I'm waiting on a shipment of reta so I can share my experience soon enough.

 

[songsofpyramids]

I started sema with no interest in its weight loss application. I’ve been lean my whole life. 0.5mg sema was enough to negate insulin issues from 3-4iu hgh every day. 0.75mg and I was started seeing pronounced metabolic recovery on blood testing, especially inflammation. 0.9mg and I struggle hit protein, but the metabolic impact has been insane. I suffered from fairly bad tinnitus and repeated autoimmune flares before starting sema, both issues have subsided to a level I can only describe as a miracle with sema. 8 months in and the government would have to pry this peptide from my cold dead hands it has improved my qol so drastic.

 

[Rippidy Dippidy]

Tirz - better for weight loss than Reta. Superior hunger suppression. Eating was a boring chore and I would struggle to eat enough calories to make meaningful gains in the gym. I lost 45 pounds before switching to Reta.
Reta - I didn’t feel true hunger suppression on Reta. I felt in control of how much or how little I wanted to eat. It’s like being on a weight loss medication but feeling like you are not on a medication. Reta was the perfect GLP to switch to for maintenance and weightlifting.

Comparing 1.25 sema, with 8mg TIRZ, with 5mg RETA.
Tirz was the worst for my weight loss.
I preferred Sema over Tirz. And I prefer Reta over both by far.
Sema and Reta appetite suppression was comparable in terms of feeling hungry again, but with Reta I seem to get full almost instantly after eating even 200g of anything really.
Only issue with Reta is getting my protein in is a chore. Muscle loss this cut was at an all time high, but then again I wasn’t angry at the world for being hungry every day.
You win some you lose some.

 

[Ghoul]

I started sema with no interest in its weight loss application. I’ve been lean my whole life. 0.5mg sema was enough to negate insulin issues from 3-4iu hgh every day. 0.75mg and I was started seeing pronounced metabolic recovery on blood testing, especially inflammation. 0.9mg and I struggle hit protein, but the metabolic impact has been insane. I suffered from fairly bad tinnitus and repeated autoimmune flares before starting sema, both issues have subsided to a level I can only describe as a miracle with sema. 8 months in and the government would have to pry this peptide from my cold dead hands it has improved my qol so drastic.

Hah, I remember discussing the effectiveness of Sema for tinnitus here.... back when you couldn't say you were using a GLP for anything more than a quick cut or you were a worthless pig lacking in all willpower, lol.

 

[songsofpyramids]

Hah, I remember discussing the effectiveness of Sema for tinnitus here.... back when you couldn't say you were using a GLP for anything more than a quick cut or you were a worthless pig lacking in all willpower, lol.

I have read some studies suggesting tinnitus is brain insulin insensitivity due to brain inflammation, and that things like post traumatic stress can cause worse inflammation including brain inflammation and thus brain insulin insensitivity as a theory for why so many people suffering ptsd have tinnitus. All I can say is that it is a miracle drug. It has made my ears/brain quieter than it has been in 15 years, and I sincerely hope it is being studied for it. I’ve reported it to every doctor and specialist I’ve come in contact with in hopes it will be studied. I know they’re running studies on it as a neuroprotective for Alzheimer’s. Anyone with tinnitus, inflammation issues, insulin issues, or family histories of Alzheimer’s should probably look into finding a dose of glp1 that doesn’t impact their appetite and riding it, or using it to reach healthy weight and then riding it.

 

[Ghoul]

I have read some studies suggesting tinnitus is brain insulin insensitivity due to brain inflammation, and that things like post traumatic stress can cause worse inflammation including brain inflammation and thus brain insulin insensitivity as a theory for why so many people suffering ptsd have tinnitus. All I can say is that it is a miracle drug. It has made my ears/brain quieter than it has been in 15 years, and I sincerely hope it is being studied for it. I’ve reported it to every doctor and specialist I’ve come in contact with in hopes it will be studied. I know they’re running studies on it as a neuroprotective for Alzheimer’s. Anyone with tinnitus, inflammation issues, insulin issues, or family histories of Alzheimer’s should probably look into finding a dose of glp1 that doesn’t impact their appetite and riding it, or using it to reach healthy weight and then riding it.

I'm hearing dementia being increasingly referred to as Type-III Diabetes, because it's become clear that insulin resistance in the brain is central to cognitive decline.

 

[ineffectual]

I started sema with no interest in its weight loss application. I’ve been lean my whole life. 0.5mg sema was enough to negate insulin issues from 3-4iu hgh every day. 0.75mg and I was started seeing pronounced metabolic recovery on blood testing, especially inflammation. 0.9mg and I struggle hit protein, but the metabolic impact has been insane. I suffered from fairly bad tinnitus and repeated autoimmune flares before starting sema, both issues have subsided to a level I can only describe as a miracle with sema. 8 months in and the government would have to pry this peptide from my cold dead hands it has improved my qol so drastic.

I love that it helped you with tinnitus, a little jealous too.

 

[Ghoul]

I love that it helped you with tinnitus, a little jealous too.

Sema is the GLP that can penetrate the blood brain barrier most easily as well, so that may play a part:

https://www.tinnitusjournal.com/articles/hyperinsulinemia-and-tinnitus-a-historical-cohort.pdf

 

[ineffectual]

Sema is the GLP that can penetrate the blood brain barrier as well, so that may play a part:

View attachment 342971

https://www.tinnitusjournal.com/articles/hyperinsulinemia-and-tinnitus-a-historical-cohort.pdf

Mines from shooting an sks with my brother and no ear protection. That was a long time ago. A few months ago I brought it up to him that I had tinnitus pretty bad and I'm pretty sure it was from that day. My head hurt so bad for a few days after that. He laughed and told me he has bad tinnitus and from what he can remember it started that day. Good times.

Sema helped me get rid of the fat so I can finally see the results of my tiny gains but never helped with the constant ringing. Background noise and glp1s for life!

 

[Ghoul]

Mines from shooting an sks with my brother and no ear protection. That was a long time ago. A few months ago I brought it up to him that I had tinnitus pretty bad and I'm pretty sure it was from that day. My head hurt so bad for a few days after that. He laughed and told me he has bad tinnitus and from what he can remember it started that day. Good times.

Sema helped me get rid of the fat so I can finally see the results of my tiny gains but never helped with the constant ringing. Background noise and glp1s for life!

Lenire ® - Tinnitus Treatment Using Bimodal Neuromodulation

Lenire tinnitus treatment technology combines audio and mild tongue pulses to provide clinically proven relief from tinnitus.

www.lenire.com

Supposed to be effective for 70% with sound trauma induced tinnitus (ie 150db+). FDA approved treatment.

 

[mattox]

There's no justification for blasting the people using GLPs to get healthier and the body they want.

@Ghoul, I love what you bring to this forum, man. I've seen you take a lot of heat from a lot of people here. I want you to know I appreciate you, brother.

For both my wife and I, we found that Tirzepatide greatly reduced the desire for sweets and alcohol. Neither of us were obese, but were certainly at an unhealthy weight with plenty of visceral fat. Tirzepatide has been a godsend for us.

GLP-1 agonists are a tool. Nobody in their right mind would try to drive a nail into a board with a rock when they had a hammer sitting right there.

 

[Ghoul]

@Ghoul, I love what you bring to this forum, man. I've seen you take a lot of heat from a lot of people here. I want you to know I appreciate you, brother.

For both my wife and I, we found that Tirzepatide greatly reduced the desire for sweets and alcohol. Neither of us were obese, but were certainly at an unhealthy weight with plenty of visceral fat. Tirzepatide has been a godsend for us.

GLP-1 agonists are a tool. Nobody in their right mind would try to drive a nail into a board with a rock when they had a hammer sitting right there.

We see the dynamic here all the time in the new member posts.

Guy begins with a GLP, loses weight and starts to feel better. No longer having to dedicate all his "bandwidth" to resisting his appetite, so starts focusing on other aspects of health, exercise, hormone optimization, etc.

On a macro scale, food sales clearly show changing preferences, from sweet crap to higher protein, smaller portion products and food companies have had to change their lineups in response. I have no doubt that's because GLPs free people from unrelenting cravings, and many make better choices.

 

[Nunya]

@Ghoul, I love what you bring to this forum, man. I've seen you take a lot of heat from a lot of people here. I want you to know I appreciate you, brother.

For both my wife and I, we found that Tirzepatide greatly reduced the desire for sweets and alcohol. Neither of us were obese, but were certainly at an unhealthy weight with plenty of visceral fat. Tirzepatide has been a godsend for us.

GLP-1 agonists are a tool. Nobody in their right mind would try to drive a nail into a board with a rock when they had a hammer sitting right there.

Amen. My husband is on a mere 2.5mg of tirz and it's essentially cured his sleep apnea and his IBS, and he's also lost quite a bit of weight. We are both in this for the longest haul possible.

 

[Grandpa]

@Ghoul I've used the search function and haven’t found any significant discussion about muscle loss on glp1s can you please address how I might mitigate this concern. Is either Reta or tirz better for maintaining muscle mass? I am current running a blast but picking up more soft tissue than I would like.

I wondered if I might be able to eat at maintenance and run Reta for 15 weeks to stay lean. Even considering Tirz for some appetite suppression but I am concerned about slowing down digestion too much. Still hoping to gain some lean mass through all this.

I apologize if I sound like a dummy. Just try to learn the ins and outs of all this.

 

[Ghoul]

@Ghoul I've used the search function and haven’t found any significant discussion about muscle loss on glp1s can you please address how I might mitigate this concern. Is either Reta or tirz better for maintaining muscle mass? I am current running a blast but picking up more soft tissue than I would like.

I wondered if I might be able to eat at maintenance and run Reta for 15 weeks to stay lean. Even considering Tirz for some appetite suppression but I am concerned about slowing down digestion too much. Still hoping to gain some lean mass through all this.

I apologize if I sound like a dummy. Just try to learn the ins and outs of all this.

There's no significant difference in lean mass preservation with Tirz or Reta. They both enhance lipolysis so slightly favor fat loss in a calorie deficit. That's why newest GLPs being developed have some component (like IGF receptor agonists) that preserve muscle or stimulate growth, .
The most effective things you can do for muscle while using the GLPs we have now are:

1: Add Testosterone if not already doing so
2: Add rHGH (this will significantly shift body composition to lean mass in a calorie deficit)
3: Ensure you're getting 1g+/kg protein. 2g/kg is ideal. Below .8g you'll lose lean mass in part because GH to IGF conversion will be crushed when protein is low. Studies show approx 40%.

If you do this, along with Test/GH, you'll preserve and even add lean mass while losing fat in as much as a 20% calorie deficit. Basically making your own "next gen muscle preserving GLP" with separate ingredients.

 

[Grandpa]

There's no significant difference in lean mass preservation with Tirz or Reta. They both enhance lipolysis so slightly favor fat loss in a calorie deficit. That's why newest GLPs being developed have some component (like IGF receptor agonists) that preserve or even build muscle.

The most effective things you can do for muscle while using a GLP are:

1: Add Testosterone if not already doing so
2: Add rHGH (this will significantly shift body composition to lean mass even in a deficit)
3: Ensure you're getting 1g+/kg protein.

If you do this, along with Test/GH, you will preserve and even add lean mass while losing fat in as much as a 20% calorie deficit.

Thank you sir. That all makes sense. With the metabolism boost from the glps, is it safe to assume that what is now maintenance would become a slight deficit while running Reta or Tirz?

 

[Ghoul]

Thank you sir. That all makes sense. With the metabolism boost from the glps, is it safe to assume that what is now maintenance would become a slight deficit while running Reta or Tirz?

Metabolism isn't boosted. It'll, at least initially, slow on both in a caloric deficit. It slows less on Reta, and at higher doses 6mg+, the data suggests it may actually increase from the pre caloric deficit baseline. But Lily either hasn't measured this or isn't releasing the data, so it's a guess extrapolated from the data we have access to.

Both increase lipolysis, so fat cells release stored energy, but actual base metabolic rate (BMR) declines since that's the natural reaction to a calorie deficit.

Both test and gh increase base metabolic rate though, so there's a good chance they'll counteract any decline in metabolism. Some kind of mild stimulant like caffeine or modafinil could help offset how much of slowdown you feel too.

Adding muscle mass will increase BMR of course.

 

[Grandpa]

Metabolism isn't boosted. It'll, at least initially, slow on both in a caloric deficit. It slows less on Reta, and at higher doses 6mg+, the data suggests it may actually increase from the pre caloric deficit baseline. But Lily either hasn't measured this or isn't releasing the data, so it's a guess extrapolated from the data we have access to.

Both increase lipolysis, so fat cells release stored energy, but actual base metabolic rate (BMR) declines since that's the natural reaction to a calorie deficit.

Both test and gh increase base metabolic rate though, so there's a good chance they'll counteract any decline in metabolism. Some kind of mild stimulant like caffeine or modafinil could help offset how much of slowdown you feel too.

Adding muscle mass will increase BMR of course.

I’m running a test/primo cycle at 600/500.

Would it be reasonable to boost fat loss by just adding in GH and staying at what has been maintenance up till now? I’m really only looking to lose 10-15lbs or about 5% body fat over the next 15 weeks. I’m 5’6” and 160lbs. My IGF1 is 230.

 

[Avies48]

What about ldl and cholesterol reduction ? Is sema, tirz or reta the best?? Ive got sema snd tirz… currently just havent touched them yet

 

[Fat]

Comparing 1.25 sema, with 8mg TIRZ, with 5mg RETA.
Tirz was the worst for my weight loss.
I preferred Sema over Tirz. And I prefer Reta over both by far.
Sema and Reta appetite suppression was comparable in terms of feeling hungry again, but with Reta I seem to get full almost instantly after eating even 200g of anything really.
Only issue with Reta is getting my protein in is a chore. Muscle loss this cut was at an all time high, but then again I wasn’t angry at the world for being hungry every day.
You win some you lose some.

Why do you prefer Semaglutide over Tirz?

 

[Ghoul]

I’m running a test/primo cycle at 600/500.

Would it be reasonable to boost fat loss by just adding in GH and staying at what has been maintenance up till now? I’m really only looking to lose 10-15lbs or about 5% body fat over the next 15 weeks. I’m 5’6” and 160lbs. My IGF1 is 230.

That should do it.

I just happened to look at what was, granted, a small scale study, and yes it was on older males, where gh alone, test alone, and a combo was used. The fat loss on the combo was much larger than either alone or added together. . GH increases androgen receptor density in muscle tissue, and Testosterone increases IGF production in muscle, so the recomposition results of the 2 used together appear to be far more than the sum of their parts.