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Andavari said:
Fuckers - so frustrating. Thanks for the info
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When packages start to flow again, use that window of opportunity to build a stock of essentials. This situation is not going to get any better going forward. Look at how difficult (virtually impossible for many) it is getting India pharma into the EU. Canada not too much better.

We've had it easy for a long time, but those days are quickly coming to an end. Don't wait until it's too late. Advanced warning is unlikely. All of a sudden seizures will just skyrocket, and it may not be temporary like in the past.

With. few exceptions, most meds are good for 10, even 30 years in cool, dark storage conditions, and India pharma into aluminum blister packs are ideal for long term preservation.
 
hexagonal said:
Fact of the matter is, cholesterol does not pass through the blood brain barrier - it can't pass through it.
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I remain unconvinced of this "fact".

The blood brain barrier itself is mostly composed of cholesterol.
 
Ghoul said:
When packages start to flow again, use that window of opportunity to build a stock of essentials. This situation is not gong to get any better going forward. Look at how difficult (virtually impossible for many) it is getting India pharma into the EU. Canada not too much better.

We've had it easy for a long time, but those days are quickly coming to an end. Don't wait until it's too late. Advanced warning is unlikely. All of a sudden seizures will just skyrocket, and it may not be temporary like in the past.
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Fortunately, I have a huge level of stock with all my base test and AAS including what I was reaching out to pct about. I feel good keeping my stock high just in case of this kind of thing happening, very very true though, you never know what's going to happen. I still have a couple months of fenofibrate which I was going to order from him but hoping that is sufficient for however long this lasts.
 
eryximachus said:
I remain unconvinced of this "fact".

The blood brain barrier itself is mostly composed of cholesterol.
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i certainly don't have an issue with you questioning it. You prompted me to look into just how enough cholesterol is supplied to build the brain, Obviously a LOT of cholesterol is required in a short period of time for it to form since as you say, it's mostly comprised of cholesterol.

1. Maternal cholesterol is the initial building material. This is why statins are not to be used by pregnant women.

2. After the fetal liver develops, it goes into overdrive synthesizing cholesterol passed into blood. which accelerates brain development.

3. Almost immediately the brain's own cholesterol synthesis also starts contributing to its own growth.

4. After the brain reaches the final stage of fetal development, the blood barrier forms, cutting off lipid exchange with blood, and the brain maintains its own cholesterol homeostasis, producing what it needs, and using specialized transporters to break down excess cholesterol into a form that can pass out of the BBB and into the blood for disposal.

IMG_2368.webp
 
Ghoul said:
i certainly don't have an issue with you questioning it.
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I don't take issue with people questioning science when they have some sort of actual rational argument or reason for their skepticism, but this dude never does.

When you have no idea what you're talking about and are questioning the science because you can't take the time to understand things, you're not doing science, you're just being an asshole.

eryximachus said:
When it comes to statins, I believe that like many drugs we do not fully understand how they work and caution should be warranted - like they should be for every drug. The way they have been promoted forever is wrong. Cholesterol is not "bad". As I said, it is the sole substance that differentiates plans from animals.
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Statins are some of the most widely prescribed drugs on the planet with some of the most data around the health outcomes.

In general we have MASSIVE data sets on outcomes related to LDL. We have a solid understanding of the mechanisms around why LDL is bad for cardiovascular health. We have tons and tons and tons of data on outcomes for people on statins vs. people off of them.

Are they perfectly understood? No. Are they some of the best understood drugs on the market today? Yes.

So you don't want people on AAS with known risks around lipids using statins, but meanwhile, you think all of us should be keeping anti-psychotics on-hand. Makes sense.
 
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hexagonal said:
I don't take issue with people questioning science when they have some sort of actual rational argument or reason for their skepticism, but this dude never does.

When you have no idea what you're talking about and are questioning the science because you can't take the time to understand things, you're not doing science, you're just being an asshole.


Statins are some of the most widely prescribed drugs on the planet with some of the most data around the health outcomes.

In general we have MASSIVE data sets on outcomes related to LDL. We have a solid understanding of the mechanisms around why LDL is bad for cardiovascular health. We have tons and tons and tons of data on outcomes for people on statins vs. people off of them.

Are they perfectly understood? No. Are they some of the best understood drugs on the market today? Yes.

So you don't want people on AAS with known risks around lipids using statins, but meanwhile, you think all of us should be keeping anti-psychotics on-hand. Makes sense.
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It is unbelievable how much shit information is out there and proliferating even now regarding cholesterol.

Any videos supporting the belief statins (all low profit cheap generics now btw) are a pharma conspiracy gets a million likes, while the videos from calmly speaking lifelong preventive cardiologists / heart surgeons pointing to 50 years of outcome data, and the way every alternative theory regarding causes of arteriosclerosis has been affirmatively disproven (usually decades ago) gets 7 views, lol.

I get it. Early statins got a bad reputation for good reason. Even modern statins give some reason to be cautious if you're prone to diabetes (small increase in insulin resistance might be the straw that breaks the camels back) or athletic (minor coq10 depletion, minor rediction in muscle mitochondrial function, and ofc low risk but not zero of muscle pain).

But now we even have an option that essentially negates those concerns.

Or go for a PCSK9 inhibitor and ezetimebe to avoid statins if you must.

But whatever you do, just don't allow plaque to continue to accumulate by tolerating LDL above 60. That's something we know for sure will reduce your risk of being taken out by the #1 killer of adults. Start early enough and it's a risk that's completely preventable (unless Lp(a) is high, but that's genetic).
 
My three are all still in limbo

Screenshot_20250907_090723_Chrome.webpScreenshot_20250907_135522_Chrome.webpScreenshot_20250907_135608_Chrome.webp

Prayering for movement soon!

The interesting thing is that it's saying that the one that left a day later, is likely to show up sooner that the two shipped the day before.
 
PCT24X7 PHARMACY said:
Positive news is some packages entered into customs and 50% of them cleared within couple of hours , India post will be resumed by Thursday or Friday as well as per internal news from postal official , we will post an update as soon it a go from officials in written .
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This is encouraging and giving hope, thank you for the update. :)
 
hexagonal said:
I don't take issue with people questioning science when they have some sort of actual rational argument or reason for their skepticism, but this dude never does.

When you have no idea what you're talking about and are questioning the science because you can't take the time to understand things, you're not doing science, you're just being an asshole.
Click to expand...

Friend, you couldn't explain the purported mechanism of the blood brain barrier in this context, or any context, if your life depended on it. I'm reviewing what purported evidence exists, though it is scant, and it would appear this hypothesis is relatively recent.

You have a particular belief based on what others have told you. You are no different than a Christian who believes Jesus was some sort of god.

So let's chill.
 
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