Possible to remove impurities from raws?

[knucklesamich]

I got thinking, yes-there's a couple live brain cells left in my head, so still possible. Scary though right?

How possible is it to remove the impurities from a raw, something like Deca? If it's possible, and I imagine there's got to be some way to do so, how reasonable is it to accomplish? Let's say, you had 100 grams of Deca that came in at a theoretical purity level of 85%. How could you take that raw powder and get it to that 99% - 100% purity level? I think that would be a really cool thing to be able to do.

 

[HeatherSwanson]

Thread 'Save your unusable raws Guaranteed.'

Apr 17, 2025

Raising the Standard​

The purpose of this thread is to present a comprehensive, reproducible, lab-grade method for purifying steroid raws prior to conversion. This is not a replacement for quality manufacturing..
this is a corrective technique to deal with substandard materials when no other option is available.


We must be clear: this is not an excuse for manufacturers to cut corners. This is a stopgap solution that allows individual compounders and responsible middlemen to clean up contaminated or adulterated product until true GMP-level practices are...

• TheScholarOfBrew
• Replies: 341
• Forum: Analytical Lab Testing

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The search function unfucks life's mysteries

 

[knucklesamich]

Ah, yeah, I actually started reading that before I knew there was a reply here. Appreciate pointing me in the right direction.

It looks pretty cool, IDK if I have it in me to attempt such a thing. I do imagine myself sending it in to this good man to get an improvement on it though, if I had a batch of raws that were low purity. Tracking

 

[TheScholarOfBrew]

Ah, yeah, I actually started reading that before I knew there was a reply here. Appreciate pointing me in the right direction.

It looks pretty cool, IDK if I have it in me to attempt such a thing. I do imagine myself sending it in to this good man to get an improvement on it though, if I had a batch of raws that were low purity. Tracking

I need to try out the more liquid type raws eventually. Unfortunately haven't had it on hand and not anyone who's needing it. I do have NPP being sent over so kinda close. We shall see. Its just a slow burn towards progress for now. No one has proof until jano data starts coming in. That will seal the deal.

 

[knucklesamich]

I like your plan. I think it's an awesome idea. I'd pay to do such a thing, I think others would too. I don't think manufacturers will get lazy because you're there to clean up after them, not at all, I think they aren't sure themselves what the purity will be until their product is complete. We've all seen it though, stuff that comes back from jano testing and it's like 92% purity. I see it a lot with Deca for some reason, purity in the 80s.

It makes me wonder, what causes this impurity? Is it that some of it is the product itself but with no ester? Is it unused ester, some of it didn't bind? Or is it something else, something uknown (that's the scary one)? Is it all of the above? Pretty cool stuff : )

 

[Rand]

I have the book on the old pharma processes

Its not on my phone right now

I normally work backwards

Lcms, get the identity of the impurity peaks

If you are the manufacturer, you adjust the chem process

If not then extractions, chiral resolutions, or prep chromatography again

But at 1 kg of product, you gonna be purifying for ages without industrial equipment

It is always better to fix the process from the start of synthesis

 

[HeatherSwanson]

I have the book on the old pharma processes

Its not on my phone right now

I normally work backwards

Lcms, get the identity of the impurity peaks

If you are the manufacturer, you adjust the chem process

If not then extractions, chiral resolutions, or prep chromatography again

But at 1 kg of product, you gonna be purifying for ages without industrial equipment

It is always better to fix the process from the start of synthesis

I would be SUPER interested in seeing that if you'd be willing to share

 

[Rand]

I would be SUPER interested in seeing that if you'd be willing to share

I get back to you. It's in my desktop.

Just the nandrolone synthesis.

 

[Rand]

Here's lednicer

 

[Rand]

Here's the manufacturing manual page 1

 

[Rand]

Page 2