Actually... very interesting you brought this up.
The most ideal TRT, replicating natural testosterone diurnal variation in young men, would be daily a.m. inj of TNE plus a longer ester. A healthy young man's testosterone typically drops 30% between the morning and evening, in old age this curve flattens out. Current TRT paradigms either maintain a steady state level via daily microdosing or multi-day variations with less frequent administrations.
I've been using Arail's TNE as preworkout and libido enhancer a couple days a week, it's amazing for that. But I've become more interested in trying the daily TNE/enanthate combo. I had to use suspension in the graph below because TNE is not a selectable option, but suspension = PIP and also has a dual spike in blood levels, being particles rather than dissolved (the graph does not reflect this, and would be identical for TNE if it were available).
Attached are graphs showing the diurnal variation in T levels with young versus old men, and blood levels with daily injections of enanthate alone at 20mg/day versus 16mg enanthate + 4mg TNE/day. Same total dose, little more volume of oil as TNE is 50mg/ml, and a little more overall T as TNE has zero loss from ester weight.
I've had the same thoughts with womens' estrogen replacement after menopause. Same daily amounts are given which is far from physiologic. I have wondered how much of the elevated risk from breast/uterine cancer and prostate cancer in men is from alterations of physiologic cycling.
Should I give this a try?