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Accutane permanent cure?
- Thread starter Ghoul
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Cheers. It's basically another month at 200*.8 to account for that. I might throw it in after vacation to make sure dependent on breakouts. If I do I'll probably just do that whole month to nuke it.
Yeah it feels a long way away when you start! But at such a high dose it just starts chipping away quite nicely.
I had a spreadsheet where I basically had cumulative dose for someone 90kg and 100kg and the totals at 120mg/kg, 150mg/kg, and finally 220mg/kg. I set the numbers so it would tell me how much % of the way I was in and exactly how many days were left until I hit the number. Assuming you continue to tolerate sides well, it'll fly by before you know it.
holy shit this has been happening to me too. I actually decided to cut out HGH, in part for this reason. I've never even had acne problems from gear before.
My solution if it doesn't go away is to go to tanning salon. I'm old enough where I don't give a fuck anymore about skin cancer.
explodingHeart
Member
yup. I was mother fucking FOURTY years old with zero acne despite anything I've did in life. Even 750mg deca week I had low BP with zero meds. GH fucking wrecked me hard. Even 3iu started giving me acne and BP issues.
God damn.
I'm 47. I don't know what to make of it.
explodingHeart
Member
I feel yah. Especially because everyone online is saying how amazing GH and how it's the fountain of youth. But even small doses fuck me up. Maybe I'll just try 1iu again as I age for health purposes.
I’m taking 1.4 iu right now, seems to be working.
Ghoul
Member
Titration is key.
Canadian endocrinologists came out rHGH treatment guideline in 2023 that are a
composite of "best practices" from multiple other guidelines (since they vary a lot).
To minimize side effects for adults, the consensus is sides can be largely avoided by starting at 0.6 iu, and increasing by another 0.6 iu every 30 days until the IGF goal is reached.
This starts on page 13, and goes into what to test along the way, adding thyroid hormone, etc.
Remember 1mg=3iu. (they use doses specified in mg)
dinfar1337
New Member
for @unclebob and anyone who wanna learn
accutane powder comes in a orange raw powder
brewed the solution will be a thick orange solution.
you can just brew it however you like but theres a patents for it, you can choose whichever you like from google
brewing process was just what i copied from some patent i found on google
dissolved in edible oils to increase absorption and prevents degradation, i used olive oil and pharma uses soybean oil
add a antioxidiant, i did vitamin e because its readily available and easy to order
what @Ghoul pointed out earlier isotrenin both powder, and in solution is extremely suspectible to degradation from air and light. you need to keep the solution airtight and away from light.
so amber vials/opaque capsules is the way forward. purge the air however you like.
if you make many pills at once you should flush with nitrogen to minimize the oxygen.
if you just make 30 for the next 30 days you can skip the nitrogen part.
if you dont have a proper brewing setup, you can try adding foil over a beaker and flush with bunch of nitrogen and add a antioxidant fast to keep air out of there. but you're spinning your wheels and i wouldn't recommend this to non brewers. just buy accutane from india.
finally, store in the fridge or put in a box where you can remember to take it away from sun light and heat!
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depression lol
dinfar1337
New Member
update on 200mg:
ive reached acculamtive dosage of 200mg/kg bw few months back.
i used nac and tudca to keep liver fine
i've noticed hemostasis coagulation factor (aptt) since then have went from in range to slighty out of range at 41 seconds now. and normal range is from 25-35 seconds.
it could indicate liver disease although im skepitcal ive made my doctor agree to a full liver scan consisting of ct, mri, and ultrasound.
since its been few months and my aptt time havent gone down at all even though my platelets have been fine for the whole time. my time at the doctor is scheduled in 2 weeks so ill update again there.
ive reached acculamtive dosage of 200mg/kg bw few months back.
i used nac and tudca to keep liver fine
i've noticed hemostasis coagulation factor (aptt) since then have went from in range to slighty out of range at 41 seconds now. and normal range is from 25-35 seconds.
it could indicate liver disease although im skepitcal ive made my doctor agree to a full liver scan consisting of ct, mri, and ultrasound.
since its been few months and my aptt time havent gone down at all even though my platelets have been fine for the whole time. my time at the doctor is scheduled in 2 weeks so ill update again there.
Banana Joe
Member
I ran isotretinoin for maybe 4-6 months 2 years ago, and my acne mostly went away, of course I then stopped taking it, so I have now restarted around 2 months ago, both times at around 15mg ed. I am still have acne, and am now just in the purging phase, so I expect to run for a whole longer.
Now, I am trying to get to the gist of micro-dosing it for better skin in general. After I (hopefully successfully) treated the acne and then ran it for another 2 months, can I then just keep running it at 5mg to keep my skin fresh?
Or should one not run the 5mg year round because of bone and vitamin D issue?
Now, I am trying to get to the gist of micro-dosing it for better skin in general. After I (hopefully successfully) treated the acne and then ran it for another 2 months, can I then just keep running it at 5mg to keep my skin fresh?
Or should one not run the 5mg year round because of bone and vitamin D issue?
Ghoul
Member
The TLDR of this, after I dug really deeply into it, is unless you're some edge case (which you aren't having survived a normal course of treatment):
1: Yes 5mg / daily microdose offers similar benefits to skin aesthetics and anti aging that exceed high strength daily topical retinol used everywhere. It remodels skin layers deeper than any topical can reach.
2. There is a growing body of evidence it's protective against numerous forms of skin cancer.
3. Health harms, for all practical purposes, even with essentially indefinite use, with this tiny dose are non-existent, outside of developing serious liver disease from some other cause or becoming a hardcore alcoholic, in which case its placing a tiny additional stress on your liver, but much lower than the lowest dose of acetaminophen / paracetamol (Tylenol) would, for instance.
Banana Joe
Member
Ok, thanks for the reply.
If that is reasonably accurate, it almost seems like a no-brainer to just keep running it.
I assume I could speed up the treatment buy upping the dose to higher than my 15mg, but I am not too bothered by my acne at the moment, and I already got pretty dry skin on my limbs.
But I read about 6-9 months being the longest desirable length of treatment, due to the bone and D3 issue - should I be bothered, by potentially exceeding that length, due to my dose being only being 15mg? The cumulative dose will obviously not be an issue.
If that is reasonably accurate, it almost seems like a no-brainer to just keep running it.
I assume I could speed up the treatment buy upping the dose to higher than my 15mg, but I am not too bothered by my acne at the moment, and I already got pretty dry skin on my limbs.
But I read about 6-9 months being the longest desirable length of treatment, due to the bone and D3 issue - should I be bothered, by potentially exceeding that length, due to my dose being only being 15mg? The cumulative dose will obviously not be an issue.
dinfar1337
New Member
only one way to find out.
keep it pushing
or run 5mg yearly and see if you'll eventually get injured
Ghoul
Member
Data is pretty thin for this protocol. But for long term use no derm is going beyond 1mg/kg per week cumulative dose (daily microdose or "pulsed" like higher doses three times a week). No safety issues seem to have come by following this rule of thumb. For an "acne reset" or sebaceous oil suppression refresher, usually it's the higher dose "pulsed" method for 8 months to a year.
Obviously though, 5mg / day is even more
conservative, with a huge margin of safety, about half or less of the 1mg/kg weekly total cumulative rule of thumb, and referred to as an "ultra microdose", so far documented out to at least 3 years (but has been quietly used by derms for 20 years already).
docpepper
Member
I recall seeing you post some interesting info on using accutane for loose skin post weight loss. I assume the 5mg/day microdose is the right dose for this use?
Ghoul
Member
That was this. They used 20mg 3x week for 12 weeks.
Durability of the improvement of collagen I and collagen III with the use of oral isotretinoin in the treatment of photoaging - PubMed
Low-dose ISO is effective in remodeling the extracellular matrix (ECM). This study found that the increase of collagen occurs through the augmentation of both collagen I and collagen III fibers. With originality, it was possible to verify the durability of these fibers for at least 12 weeks...
pubmed.ncbi.nlm.nih.gov
Banana Joe
Member
At my body weight, I am even almost below 1mg/week at my therapeutic dose of 15mg, so I guess I can just keep taking that as long as I have to for my acne, and then drop to 5mg indefinitely to retain my natural beauty.
Should I keep taking my therapeutic dose for another 2 months, should I taper off to 5mg progressively, or can I drop to 5mg immediately, once my acne has cleared up entirely?
It is my understanding the pulsing was done for compliance, or to potentially reduce side effects?That was this. They used 20mg 3x week for 12 weeks.
Durability of the improvement of collagen I and collagen III with the use of oral isotretinoin in the treatment of photoaging - PubMed
Low-dose ISO is effective in remodeling the extracellular matrix (ECM). This study found that the increase of collagen occurs through the augmentation of both collagen I and collagen III fibers. With originality, it was possible to verify the durability of these fibers for at least 12 weeks...
Or is there any point in not just taking it as 10mg ed other than that?
PS: You can't even get a prescription for that nano stuff here. Should I really care about getting it, when I can get the other stuff for free?
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Ghoul
Member
The best long term outcomes for acne, besides the 220mg/kg cumulative dose, were achieved when treatment continued for 50 days after full clearance.
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As to collagen, based on the study I linked, the genes that renew collagen behave like switches. They need a certain intracellular retinoic acid concentration to trigger collagen synthesis. Pulses above that threshold transiently induce collagen synthesis and suppress MMP-9 (collagen degrading enzyme) more effectively than constant sub-threshold exposure.
The daily low dose is more effective at skin improvement the upper layers. But there is still a positive impact on collagen, it's just slower.
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Honestly as appealing as the nano stuff is, I now have several supplements (coq10, k2/d3) that must be taken with food containing fat for proper absorption, so I just take my 5mg accufine with the rest, usually with a cup of coffee and 1/2 oz coconut milk. Allows me to maintain my morning fasted state (mostly). A spoonful of MCT oil would be just as effective.
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