Tesa/Ipa Bloodwork

tree_respecter

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1000002432.webpReference:
-34 y/o Male
-Lifting 4x week, PPL + Full-body
-Dedicated LISS 1-2x week

Protocol:
-400mcg Ipa post-workout
-400mcg Ipa before bed
-2mg Tesa before bed

Other supps:
-3mg Reta 2x weekly (6mg total)
-2000iu vit d3 daily
-5g creatine daily
-Greens powder daily
-Men's multi daily

Subjectively:
First few weeks experienced joint pain and transient edema. Subsided by week 3. Sleep is phenomenal. workout recovery has also been great w/ noticeably reduced DOMS.

Bloodwork taken 9/29/25 10:30am. This is about 3 weeks into protocol.

Im wondering about the threshold of diminishing returns in terms of igf-1. Is there a natural ceiling at which point an increase in serum igf-1 or gh disproportionately increases unwanted effects? Because I am not taking AAS, I'm assuming that I can only realistically utilize only so much of an increase. I'd appreciate any insights.
 
Last edited:
What was your baseline. You and I are doing the samething, no AAS and I am taking 2mg of Tesa before bed.
I am taking it for same reason, just to move the needle a little bit in a positive way, improved recovery and better workouts. I am 2 months in and will take labs in 2 weeks. I too was wondering about dosing time and labs time as how it would effect true IGF-1 levels
 
View attachment 352026Reference:
-34 y/o Male
-Lifting 4x week, PPL + Full-body
-Dedicated LISS 1-2x week

Protocol:
-400mcg Ipa post-workout
-400mcg Ipa before bed
-2mg Tesa before bed

Other supps:
-3mg Reta 2x weekly (6mg total)
-2000iu vit d3 daily
-5g creatine daily
-Greens powder daily
-Men's multi daily

Subjectively:
First few weeks experienced joint pain and transient edema. Subsided by week 3. Sleep is phenomenal. workout recovery has also been great w/ noticeably reduced DOMS.

Bloodwork taken 9/29/25 10:30am. This is about 3 weeks into protocol.

Im wondering about the threshold of diminishing returns in terms of igf-1. Is there a natural ceiling at which point an increase in serum igf-1 or gh disproportionately increases unwanted effects? Because I am not taking AAS, I'm assuming that I can only realistically utilize only so much of an increase. I'd appreciate any insights.
have you ever tried HGH? I went to tesa because HGH gave me unwanted sides.
Also what time of day to you workout and why IPA post workout?
 
What was your baseline. You and I are doing the samething, no AAS and I am taking 2mg of Tesa before bed.
I am taking it for same reason, just to move the needle a little bit in a positive way, improved recovery and better workouts. I am 2 months in and will take labs in 2 weeks. I too was wondering about dosing time and labs time as how it would effect true IGF-1 levels
Can you please keep us updated? Im really interested in the before and after bloodwokr
 
What was your baseline. You and I are doing the samething, no AAS and I am taking 2mg of Tesa before bed.
I am taking it for same reason, just to move the needle a little bit in a positive way, improved recovery and better workouts. I am 2 months in and will take labs in 2 weeks. I too was wondering about dosing time and labs time as how it would effect true IGF-1 levels

Dosing time is irrelevant for Tesa. Just keep the time consistent.
 
Can you please keep us updated? Im really interested in the before and after bloodwokr
I get bloodwork tomorrow, however I did not get bloodwork prior to start of tesa. I dont know if it makes the test irrelevant, as I cannot see how much I went up, but none the less I am 43 and hoping for a decent number
 
Dosing time is irrelevant for Tesa. Just keep the time consistent.
I would disagree in that way that before bed would be the best timing as tesa wont result in only one big peak but in bigger peaks in the following hours. As our body secrets the big majority of our GH during sleep, you would get the moat out of it, when taken before bed. At least those are my thoughts about it.
 
I get bloodwork tomorrow, however I did not get bloodwork prior to start of tesa. I dont know if it makes the test irrelevant, as I cannot see how much I went up, but none the less I am 43 and hoping for a decent number
Damm it. Would have loved to see the before and after bloodwork. But will still be interesting.

I
 
have you ever tried HGH? I went to tesa because HGH gave me unwanted sides.
Also what time of day to you workout and why IPA post workout?
Sorry for the delayed responses! The last few weeks got away from me.

-I did not measure my baseline, unfortunately. I am tall at 6'5", but I don't have acromegaly or something so I've thought it reasonable to assume I don't have abnormally high or low baseline igf-1. I just didn't grab that data point. My b.

-Ive seen lots of protocols in the experimental space that suggest tesa in the morning at 1mg, but the instructions I read for Egrifta (the fda approved version/intended purpose of tesa) said before bed. Mechanistically, this aligns with the body's biggest pulse of gh. But ghoul be correct because tesa acts primarily on the overall amplitude and production of gh, not necessarily just triggering peaks. Night time, about 30 min to 1 hour before bed works better for me.

-I have not tried straight GH and I'm still on thr fence about it. I appreciate the stimulation of the HPT rather than bypassing it and possibly shutting it down. My reading of the literature is more that tesa and ipa work synergistically to increase the amplitude of endogenous GH pulses. Tesa doing the heavy lifting, presumably. I understand it's not like test, and the feedback loop shutdown from exogenous likely doesn't need any kind of pct to self-resolve, especially at my age, but I was being more cautious about entirely bypassing my body's natural balancing mechanisms when I decided to play with it.

-I typically start a workout anytime between 11am-1pm. Workouts usually last around 1.5 hours.

-This is mostly based on extrapolation and mechanistic reasoning, but I do ipa after a workout to increase the peak of gh during the (hotly debated) anabolic window. I will pin immediately after a workout, then have my biggest meal about 30-40 minutes after. Ipa has a short half life, but by 30-40 minutes I imagine it's done what it needs to and triggered a larger spike in gh and subsequent igf-1

-I'd love to see other's bloodwork! I think that it is still very relevant to get bloodwork done even without the initial data point because we do have reference ranges based on age, and we can get an idea of where we are compared to the norm. Anything above the norm will be an indicator of increased hpt output and subsequent effects.

-Im going for 60 days straight in this protocol, letting it clear, and then getting post bloodwork. After that, I'll be planning the next cycle for a few months later. Im currently cutting, so I think starting it during a late winter bulk will be really interesting in terms of mass gains.
 
Those are ideal results from Tesa. Right at the very peak of the range for your age. You're in the .02% top of your peer group for IGF. rHGH would have to be supra-physiological (with side effects) to get the same results you'll see from Tesa at the level you are,
I regret not getting lab work when I ran rHGH, like i said i worked up to 6iu and it was crippling.
 
Got labs back this morning. I am 43 and I don't take testosterone or any other anabolics.
Nice! That's a solid increase. Bouncing off the top of the reference range seems ideal. How's your recovery? Sleep? Sides?

I'm actually getting blood drawn this morning. Since my last results, I had titrated tesa down to 1.5mg/nightly just to see my dose response. I'll be curious to see how sharp the drop was and I'll post results when they come in. I'm nearing the end of my 60 days so I'll probably have another draw in 2-3 weeks.
 
Nice! That's a solid increase. Bouncing off the top of the reference range seems ideal. How's your recovery? Sleep? Sides?

I'm actually getting blood drawn this morning. Since my last results, I had titrated tesa down to 1.5mg/nightly just to see my dose response. I'll be curious to see how sharp the drop was and I'll post results when they come in. I'm nearing the end of my 60 days so I'll probably have another draw in 2-3 weeks.
I been on Tesa since begining of august. At first sleep was uninteruppted slept whole night thru not even waking up to pee. Sleep now is great but I wake up around 2-3 am and feel a ton of energy, which was similar when I was on HGH.
Recovery I cant gage, I do PPL workout 4 days a week and off days I do BJJ/MMA. I feel worn out, lots of aches and pains, it would probably be smaller if I didn't train in combat sports. I do have water retention, tendonitis has flared up and have gotten some CTS symptoms, but nothing like I had on HGH. Watching my sodium intake, has helped. But right now I am bulking so lots of carbs, muscles feel full and great. wrist and elbows are where tendonitis is at.
 
I been on Tesa since begining of august. At first sleep was uninteruppted slept whole night thru not even waking up to pee. Sleep now is great but I wake up around 2-3 am and feel a ton of energy, which was similar when I was on HGH.
Recovery I cant gage, I do PPL workout 4 days a week and off days I do BJJ/MMA. I feel worn out, lots of aches and pains, it would probably be smaller if I didn't train in combat sports. I do have water retention, tendonitis has flared up and have gotten some CTS symptoms, but nothing like I had on HGH. Watching my sodium intake, has helped. But right now I am bulking so lots of carbs, muscles feel full and great. wrist and elbows are where tendonitis is at.
Your experience sounds fairly similar to mine in terms of sleep and sides. I don't do combat sports but I can imagine that may borrow resources from muscle recovery to a degree.

Have you noticed an increase in size/mass that you could maybe attribute to the increase in gh?
 
1000003050.webp
Quick update:

After initial bloodwork, I dropped tesa down to 1.5mg and ipa down to 300mcg. I was just interested in seeing my response to dose change. It looks like titration resulted in a drop of about 100ng/ml from my previous high of 475ng/ml.

I'm about a week away from ending this cycle and then I'll do final bloodwork 30 days later.
 
Your experience sounds fairly similar to mine in terms of sleep and sides. I don't do combat sports but I can imagine that may borrow resources from muscle recovery to a degree.

Have you noticed an increase in size/mass that you could maybe attribute to the increase in gh?
Just water weight gain, however if fills me out shoulders look really good.
 
View attachment 355843
Quick update:

After initial bloodwork, I dropped tesa down to 1.5mg and ipa down to 300mcg. I was just interested in seeing my response to dose change. It looks like titration resulted in a drop of about 100ng/ml from my previous high of 475ng/ml.

I'm about a week away from ending this cycle and then I'll do final bloodwork 30 days later.
You were at 475 with tesa and ipa. Thats amazing
 
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