Question about hgh side effects

[cyx]

Do more side effects generally mean more active hgh? I know there are other factors that can influence this but is this the main indication for good hgh?

 

[pewex]

No

 

[Ghoul]

Do more side effects generally mean more active hgh? I know there are other factors that can influence this but is this the main indication for good hgh?

Let's be clear. Carpal and water retention are normal symptoms of exogenous growth hormone. Not "contaminants", or "dimer" or any other bullshit.

If you get carpal after injecting rHGH that *is* a sign that it's growth hormone.

The idiots who claim GH is "clean" or "good quality because X iu of that brand doesn't cause those symptoms, and another at exactly the same dose causes them, have it completely backwards. The one not inducing those symptoms is NOT as potent.

None of this is to say you have to have side effects. It's a sign your dose is too high and you should consider lowering it before slowly going back up, since your body can adjust if you titrate slowly, and the side effects will often diminish. But if you use large enough of a dose of any legit rHGH you will get those symptoms. That includes pharma.

Every doctor administering rHGH to patients is aware of these common side effects.

 

[Lilpiggy]

Let's be clear. Carpal and water retention are normal symptoms of exogenous growth hormone. Not "contaminants", or "dimer" or any other bullshit.

If you get carpal after injecting rHGH that *is* a sign that it's growth hormone.

The idiots who claim GH is "clean" or "good quality because X iu of that brand doesn't cause those symptoms, and another at exactly the same dose causes them, have it completely backwards. The one not inducing those symptoms is NOT as potent.

None of this is to say you have to have side effects. It's a sign your dose is too high and you should consider lowering it before slowly going back up, since your body can adjust if you titrate slowly, and the side effects will often diminish. But if you use large enough of a dose of any legit rHGH you will get those symptoms. That includes pharma.

Every doctor administering rHGH to patients is aware of these common side effects.

Are these side effects generally onset after first dose? Or is it a gradual thing?

 

[Ghoul]

Are these side effects generally onset after first dose? Or is it a gradual thing?

Often early on after starting rHGH or increasing dose, within the first few days is not uncommon. Typically subsides within the first few weeks as the body gets acclimated to that dose and other mechanisms kick in to restore water equilibrium.

 

[readalot]

I will offer a different take. There are certainly negative side effects one can experience on cheap ass UG GH that they wont with other UG GH or pharma GH. I know. I tried them.

No, not all UG GH is the same. It certainly isn't pharma. Some UG GH closer to pharma than others.

 

[readalot]

None of this is to say you have to have side effects

Carpal and water retention are normal symptoms of exogenous growth hormone

Those aren't the only potential negative side effects.

 

[readalot]

The idiots who claim GH is "clean" or "good quality because X iu of that brand doesn't cause those symptoms, and another at exactly the same dose causes them, have it completely backwards. The one not inducing those symptoms is NOT as potent.

Respectfully, we aint ever going to get anywhere here if we all talk to each other like this. I know I am guilty as well. Trying to do better.

 

[dinfar1337]

Let's be clear. Carpal and water retention are normal symptoms of exogenous growth hormone. Not "contaminants", or "dimer" or any other bullshit.

If you get carpal after injecting rHGH that *is* a sign that it's growth hormone.

The idiots who claim GH is "clean" or "good quality because X iu of that brand doesn't cause those symptoms, and another at exactly the same dose causes them, have it completely backwards. The one not inducing those symptoms is NOT as potent.

None of this is to say you have to have side effects. It's a sign your dose is too high and you should consider lowering it before slowly going back up, since your body can adjust if you titrate slowly, and the side effects will often diminish. But if you use large enough of a dose of any legit rHGH you will get those symptoms. That includes pharma.

Every doctor administering rHGH to patients is aware of these common side effects.

the gyno i have is because my test raws came back at 60% purity man.

dont blame me blame the market

 

[readalot]

We have not a clue...

Search results for query: Host cell proteins

thinksteroids.com

R

Post in thread 'USA Serostim Source - Pharmaceutical HGH'

Jun 21, 2025

Unfortunately the informative thread this reference was posted in got nuked. Not sure why. And no I'm not going to all the effort to post the relevant snippets of the article again. Huge amount of info in the deleted thread. We have no idea what host cell proteins are contained in UG products.

https://www.tandfonline.com/doi/abs/10.1185/03007991003719642

Very much worth the read when you want to consider the work that goes into qualifying pharma GH. Relevant to what may be coming along for the ride in an E Coli based UG product.

• readalot

• 

 

[Ghoul]

We have not a clue...

Search results for query: Host cell proteins

thinksteroids.com

Don't misunderstand me.

UGL rHGH may contain all sorts of horrors not yet apparent. It's just that the sides rHGH specifically induces through its normal mechanism of action, when it's taken to a supra-physiological level, are very unlikely to match random sides by genuine contaminants (host cell proteins, aggregates or whatever).

GH stimulates water attracting glycosaminoglycan production in connective tissue, too much of it causing localized tissue swelling, and nerve pressure.

Who knows what stray host cell proteins or getting just the "wrong" epitope pattern on the outside of an aggregate may cause.

Maybe the host cell proteins fragment creates a new form of cancer just for you, or the epitope pattern of a random aggregate starts a chain reaction of all your cells self destructing*. but tingling fingers, just like properly functioning rHGH, would be a hell of a coincidence.

*

 

[dinfar1337]

Don't misunderstand me.

UGL rHGH may contain all sorts of horrors not yet apparent. It's just that the sides rHGH specifically induces through its normal mechanism of action, when it's taken to a supra-physiological level, are very unlikely to match random sides by genuine contaminants (host cell proteins, aggregates or whatever).

GH stimulates water attracting glycosaminoglycan production in connective tissue, too much of it causing localized tissue swelling, and nerve pressure.

Who knows what stray host cell proteins or getting just the "wrong" epitope pattern on the outside of an aggregate may cause.

Maybe the host cell proteins fragment creates a new form of cancer just for you, or the epitope pattern of a random aggregate starts a chain reaction of all your cells self destructing*. but tingling fingers, just like properly functioning rHGH, would be a hell of a coincidence.

*

View attachment 341357

it is extremely unlikely it will mimick 100% hgh side effects. most of the "impurities" will be inactive.

not speaking of the impurities will be such a small amount we will not feel any difference. if it was true the impurities caused the "allergic reaction" because it is not hormonally active.

i dont know jackshit about peptides, but this isnt nuclear waste its not hazardous to our bodies, in terms of even side effects we would be able to feel.

maybe if u let it stand for 10 years degrading beyond too much.


i get people dont wanna believe it, they spend double amount of money with opti and lobster for better quality and dimer 0.1% that provides a better looking number, but absolutely nothing else

 

[readalot]

Don't misunderstand me.

UGL rHGH may contain all sorts of horrors not yet apparent. It's just that the sides rHGH specifically induces through its normal mechanism of action, when it's taken to a supra-physiological level, are very unlikely to match random sides by genuine contaminants (host cell proteins, aggregates or whatever).

GH stimulates water attracting glycosaminoglycan production in connective tissue, too much of it causing localized tissue swelling, and nerve pressure.

Who knows what stray host cell proteins or getting just the "wrong" epitope pattern on the outside of an aggregate may cause.

Maybe the host cell proteins fragment creates a new form of cancer just for you, or the epitope pattern of a random aggregate starts a chain reaction of all your cells self destructing*. but tingling fingers, just like properly functioning rHGH, would be a hell of a coincidence.

*
View attachment 341357

Agreed. Thank you for taking the time to provide that detailed clarification.

 

[readalot]

i dont know jackshit about peptides, but this isnt nuclear waste its not hazardous to our bodies, in terms of even side effects we would be able to feel.

Host Cell Protein Clinical Safety Risk Assessment-An Updated Industry Review - PubMed

Host cell proteins (HCP) are process-related impurities that can co-purify with therapeutic proteins. Some HCP impurities potentially can have an impact on patient safety (immunogenicity or toxicity), efficacy, and/or product quality. It is important to reduce the levels of HCP impurities with a...

pubmed.ncbi.nlm.nih.gov

Suit yourself.

 

[dinfar1337]

Host Cell Protein Clinical Safety Risk Assessment-An Updated Industry Review - PubMed

Host cell proteins (HCP) are process-related impurities that can co-purify with therapeutic proteins. Some HCP impurities potentially can have an impact on patient safety (immunogenicity or toxicity), efficacy, and/or product quality. It is important to reduce the levels of HCP impurities with a...

pubmed.ncbi.nlm.nih.gov

Suit yourself.

you're right. thats related to allergic reaction i talked about because the byproduct(host cell proteins) in my understanding isnt hormonally active and wont cause the same side effects as hgh.

 

[dinfar1337]

we would likely see allergic and immune reactions especially after injection for many many people.

there might be 1 guy who get swelling and think thats bad hgh side effect but its sooo unlikely everyone will do that.

 

[Norma Jeane Mortenson]

This thread saved me from throwing away 4 kits of blue tops. I switched from Primal-sourced black tops to Opti blue tops and almost immediately developed debilitating carpal tunnel and significant swelling. No change in dose or frequency (~2iu/day).

All the research I did suggested my side effects were dose-dependent, but I couldn’t imagine I’d see such a dramatic difference between the two sources. I convinced myself the Opti blue tops were tainted in some way or had degraded, and I began attributing my side effects to that.

I’ve been on HGH for 5 years, and I have had sides like this come and go, but never quite this severe. I skipped my injection for two days and just restarted at 1iu, and the side effects are better. Hoping to see continued improvement and to be able to titrate back up to 2iu soon.

Just thought I’d contribute this anecdote.

 

[BigDadd7]

This thread saved me from throwing away 4 kits of blue tops. I switched from Primal-sourced black tops to Opti blue tops and almost immediately developed debilitating carpal tunnel and significant swelling. No change in dose or frequency (~2iu/day).

All the research I did suggested my side effects were dose-dependent, but I couldn’t imagine I’d see such a dramatic difference between the two sources. I convinced myself the Opti blue tops were tainted in some way or had degraded, and I began attributing my side effects to that.

I’ve been on HGH for 5 years, and I have had sides like this come and go, but never quite this severe. I skipped my injection for two days and just restarted at 1iu, and the side effects are better. Hoping to see continued improvement and to be able to titrate back up to 2iu soon.

Just thought I’d contribute this anecdote.

Interesting. What conclusion do you draw from that regarding the difference between primal and opti?

 

[craigdt]

This thread saved me from throwing away 4 kits of blue tops. I switched from Primal-sourced black tops to Opti blue tops and almost immediately developed debilitating carpal tunnel and significant swelling. No change in dose or frequency (~2iu/day).

All the research I did suggested my side effects were dose-dependent, but I couldn’t imagine I’d see such a dramatic difference between the two sources. I convinced myself the Opti blue tops were tainted in some way or had degraded, and I began attributing my side effects to that.

I’ve been on HGH for 5 years, and I have had sides like this come and go, but never quite this severe. I skipped my injection for two days and just restarted at 1iu, and the side effects are better. Hoping to see continued improvement and to be able to titrate back up to 2iu soon.

Just thought I’d contribute this anecdote.

I have similar anecdote, but opposite basically.
Did 2 kits of a respected UGL and one kit of Chyna hgh.

I then switched over to Opti gold tops, with no change in dose or frequency.

Carpal tunnel and foot pain went away.

Maybe my body finally got used to the exogenus hgh?
Regardless, I stick with the Opti gold tops for now

 

[Norma Jeane Mortenson]

Interesting. What conclusion do you draw from that regarding the difference between primal and opti?

I see what you’re getting at lol. The black tops tested better though, which means maybe I should just send out a sample.

There’s also individual variability in pharmacodynamic response—it’s certainly true of drugs in general—but to see that variability between manufacturers of the same drug…yeah I don’t know about that. Maybe. Maybe Primal is just selling bullshit.