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[eryximachus]

I learned of it from @Ghoul and grateful for that knowledge. Like other doctors in USA, I didn’t even know it existed.



I was taking nebivolol previously, 5-10mg per day, and it made very little difference. Beta blockers in general are no longer prescribed for high blood pressure; only useful one in healthy adults is propranolol as it’s non-selective and lipid soluble, enabling it to readily cross the blood-brain barrier, so it has potentially useful CNS effects (anti-anxiety mostly) works in the brain unlike the newer/cardioselective others.

It seems like nebivolol was praised for its vasodialation effects for years here.

Wouldn't that in theory prevent MI type events?

 

[Ghoul]

It seems like nebivolol was praised for its vasodialation effects for years here.

Wouldn't that in theory prevent MI type events?

Nebiv is the safest of the beta blockers, but for general blood pressure control, outside of specific problems, beta-blockers as a class have been dropped from all the major medical guidelines as "first line" therapy because they don't reduce the risk of stroke like ACE / ARB, CCB, or Diuretics which are the preferred classes.

 

[PiscesMoon]

Sandoz Estradiol Transdermal System - does he carry it? 0.78mg delivers 0.05mg a day

Current list has oral tablets and creams... You can email a request for patches too.

If you are in the US, TelyRx has estradiol transdermal patches available in the Women's section - either Menopause or V Health. Shows two different types, and you may choose the strength + amount of patches as well.

Seems to be generic versions, but maybe it can help temporarily until you find a pharmacy able to fill her specific prescription.

 

[bigdaddyandfriends]

It seems like nebivolol was praised for its vasodialation effects for years here.

Wouldn't that in theory prevent MI type events?

It's a weak/secondary effect via β3 agonism; the primary/target effect is β1 blockade.

β3 agonism stimulates nitric oxide release, which is the endothelial/cardioprotective component. Best way to optimize that pathway is not nebivolol, but a combination of L-citrulline supplementation (precursor for NO, found in most preworkouts) + PDE5 (ie taladalafil and/or sildenafil), and mirabegron (specific β3 agonist). I use:

L-citrulline 5-10gm per day
Taladalafil 5mg per day (am) + sildenafil 100mg per day (preworkout)
Mirabegron 50mg per day

Pharma mirabegron is kind of expensive, but some research chem sites sell it too. I've bought pharma from PCT24x7 and also have powder from Kimera chems.

 

[bananafeet]

I learned of it from @Ghoul and grateful for that knowledge. Like other doctors in USA, I didn’t even know it existed.

ARB helped my pre-existing diastolic hypertension and hypertensive response to supraphysiologic androgens (trestolone and RAD140 in particular).

But I have a sympathetic nervous system that overreacts to work stress (and my wife when she’s hormonal) and even on 80mg azilsartan my BP would spike during the day > 150/90.

Cilnidipine fixed that, and I get a nice calming effect from it too. I’ve accumulated a nice stash in case shipping problems recur.

I was taking nebivolol previously, 5-10mg per day, and it made very little difference. Beta blockers in general are no longer prescribed for high blood pressure; only useful one in healthy adults is propranolol as it’s non-selective and lipid soluble, enabling it to readily cross the blood-brain barrier, so it has potentially useful CNS effects (anti-anxiety mostly) works in the brain unlike the newer/cardioselective others.

Hypertension is rarely controlled well with a single drug. Basically this is the way to combine them:

First line: ARB (telmisartan or azilsartan are best in class, 40-80mg/day)
Second line: CCB (Cilnidipine only, 10-20mg/day)
Third line: Diuretic (potassium-losing ie chlorthalidone or indapamide if using ARB with elevated K+, otherwise potassium-sparing eplererone, finererone, spironolactone)

Spironolactone is less selective than eplereone or finereronex, and binds to androgen receptors acting as an anti-androgen. Most men avoid it but may not be of much significance for those with supraphysiologic levels. My wife uses it and with daily microdoses of 2mg pharma winstrol or 2.5mg anavar.

Some recent studies have linked beta blocker use with bad outcomes. Mostly these were in MI patients, but another reason to avoid for blood pressure management. For RHR ivabradine is designed for and specific for that; works very well typically collateral effects.

Shit bro. Don't stress me out like this Hahha

I'm on betablockers for rate control

 

[Stealth500]

Anyone else not getting a response from their email?
2 days now, no reply.

 

[Photon]

mirabegron (specific β3 agonist)

Pharma mirabegron is kind of expensive, but some research chem sites sell it too. I've bought pharma from PCT24x7 and also have powder from Kimera chems.

I use vibegron instead of mirabegron.
My insurance covers it and it does seem to have a better side effect profile on paper.

 

[nullandvoid]

Anyone else not getting a response from their email?
2 days now, no reply.

I just placed an order last night. Last response from them was around 11PM.

 

[Tkjo]

@Photon Would you happen to know is there is a good Indian brand for Finerenone?

 

[Photon]

@Photon Would you happen to know is there is a good Indian brand for Finerenone?

Healing pharma.
My source charges sub 2$ a strip for either of the doses.
Not sure how much this vendor will charge for it tho, youd need to ask him

 

[Stealth500]

I just placed an order last night. Last response from them was around 11PM.

damn, guess I'll try another vendor.

 

[psauce]

Anyone else not getting a response from their email?
2 days now, no reply.

Huge holiday there recently. He's probably catching up.

 

[Neegan02]

Haven't seen the updated product list in a minute. Any chance they've added Pitavastatin? Can't seem to find it anywhere, and I'm trying to avoid the doctor route atm.

 

[Raww]

Haven't seen the updated product list in a minute. Any chance they've added Pitavastatin? Can't seem to find it anywhere, and I'm trying to avoid the doctor route atm.

The list I have from last month shows 1, 2, and 4mg available.

 

[Alvinq]

Haven't seen the updated product list in a minute. Any chance they've added Pitavastatin? Can't seem to find it anywhere, and I'm trying to avoid the doctor route atm.

 

[Neegan02]

@Alvinq @Raww Thanks gents

 

[Stealth500]

Huge holiday there recently. He's probably catching up.

keep refreshing my inbox to see if he's going to process my order.. Need muh drugs..grrr

 

[nullandvoid]

Haven't seen the updated product list in a minute. Any chance they've added Pitavastatin? Can't seem to find it anywhere, and I'm trying to avoid the doctor route atm.

That's actually one of the things I ordered. As much as I like and appreciate Telyrx, if I can plan ahead and pick from a known good manufacturer, the price is a no brainer.

 

[Raww]

Anyone else not getting a response from their email?
2 days now, no reply.

Nope, put in an order yesterday, had a response this morning.

 

[PCT24X7 PHARMACY]

keep refreshing my inbox to see if he's going to process my order.. Need muh drugs..grrr

I replied all emails yesterday before going to bed , if possible can you please shoot me an email again sir ,

Email - shop@pct24x7.store

It was weekend and then Diwali holidays all together we just opened pharmacy yesterday and dispatching the packages asap half were processed yesterday and rest will be done today I will be sharing tracking in next couple of hours .


Thanks & Regards
PCT24X7