MESO-Rx
Anabolic Steroids
What do you think of my bloodwork?
- Thread starter Marv123
- Start date
ganciodestro
Member
Your prolactin levels are extremely high, and your estrogen levels are more than three times above the normal range… you absolutely need to take an AI (aromatase inhibitor) and see if lowering your E2 also brings down your prolactin. If not, you’ll need to treat that separately as well.
I bet you’re also experiencing sexual issues…
I think aromasin 12.5 mg 2 time x week at minimum
I bet you’re also experiencing sexual issues…
I think aromasin 12.5 mg 2 time x week at minimum
Yes gonna start with Aromasin.
Idk why my prolactin is so high. My TSH is high which can be Hypothyroidism. I read that Hypothyroidism can also raise Prolactin.
Ghoul
Member
Need free T4 and t3, but looks like you may have hypothyroidism.
LDL is ok, but if max longevity is your goal you want it to come down by 50%
LDL is ok, but if max longevity is your goal you want it to come down by 50%
adrenalytic
Member
sheesh, 147 E2 on 200 mg test? are you 300+ lbs.?
sionnach
Banned
FilthyKangaroo
New Member
Thats terrifying to see under your post asking about bloodwork panel opinions
No i´m like 17%BF. I was also suprised by these number
BP_6
Member
Not too bad overall. Personally wouldn't worry about the E2 unless you are having issues related to it. The LDL as has been stated could be better and you might want to get your free T4 levels checked. However overall it is about what would be expected.
Ghoul
Member
The hypothyroidism you appear to have can cause it too. Also insulin resistance, and you’re higher than ideal, inflammation (hs-crp), cortisol from stress, mangnesium or zinc deficiency.
You can test for all these, but your thyroid is the strongest suspect. I’d order some T4 to have on hand before you even get the next round of bloodwork, since it’s that likely.
How your guys are lowering your LDL Lipids?
I also tested Lipoprotein (a) which is at 130 genetic wise.
So thats more than important to me
I also tested Lipoprotein (a) which is at 130 genetic wise.
So thats more than important to me
BP_6
Member
LDL can be lowered with statins. However the Lipo A is a bit more tricky. Repatha seems to help. Don't know how easy or difficult that is where you live.
Ghoul
Member
That Lp(A) is very high, and since we can’t yet lower it sufficiently (new meds soon), it acts as an LDL “risk amplifier”. Each 50 points of Lp(a) is equivalent to 15-20 nmol higher LDL.
Keep in mind though, without sufficient LDL, the building block of plaque, the other factors like Lp(A) or low HDL become minor (worth addressing later but not contributing to a lifetime of increasing risk like they would when combined with LDL >70)
You have been carrying that additional risk for a lifetime, so a good lipodologist would try to get you below 55 nmol to stop, and possibly reverse some accumulated damage.
Ezetimibe and Pitavastatin 4 can bring your LDL down by ~60% with extremely low risk of any side effects. It’ll also bring inflammation down by 50% or more, lowering your e2.
You’d benefit from a PCSK9 inhibitor too, bringing LDL even lower, and reducing Lp(a) by 30%, but you have to have a cooperative doc and be a little manipulative to get it.
Also, it’s probably worth letting your family members / children know you have very high Lp(A) and they should let their doctors know and get it tested too.
BP_6
Member
My doc flat out told me he could request it. However since the statin was doing a fine job along with the zetia, he said it would be extremely unlikely in his experience with my insurance they would approve it. So I told him not to bother.
Ghoul
Member
Pro tip, in the US it’s useful to say to your primary care doctor “many on my mother’s side seem to have a heart attack or stroke young”, which, once in your record, marks you as “family history of cardiovascular disease” opening up access to easy approval for advanced tests and meds lime Repatha.
Most insurance does now cover it if you have “ a “family or personal history of heart disease or premature cardiovascular disease (under 45 men/55 women)” since that’s in the American Heart Association guidelines for Lp(A) testing.
Or just spend $25 (after 20% off coupon) and get it done yourself and give the results to your doc if high:
I'm only 23, but I think it still makes sense to try to get statins, right?
Apparently, new drugs will soon be available to lower lipoprotein(a).
“Lowering lipoprotein(a) with antisense oligonucleotides”
Sounds good
sionnach
Banned
You're going to get a lot of YESes here, there are a bunch of old dudes who have had a shitty diet their whole lives backpedaling as fast as they can to avoid the grim reaper. And that answer might be yes for you too - statins are extremely effective at lowering that one scary number on your labs. But you have to make that decision yourself. Do your research. Read about the side effects. And read about other things you can do like change your diet and...recreational intake. Don't just do it because it's a cheap fix and some randos on the web went "OMG your LDL!"
Ghoul
Member
You’re already accustomed to “biohacking” yourself with compounds and have the discipline to manage doses, timing, blood markers etc, so you’re one of the very rare people your age well positioned to manage your long term health at a time, like a great investment made very early, when your foresight can pay off like a lottery win later.
Once plaque deposits in your blood vessels, it’s mostly permanent. It starts early in life. It’s mostly genetic. The less you have, the healthier you’ll be for a lifetime. The ideal would be stopping it before it starts. Your cardiovascular system will never be as clean as it is today.
Limited resources, not the science, is the reason the guidelines don’t focus on stopping it early. But if your father was a cardiologist, I’m certain he’d have you on lipid lowering meds to protect your arteries while they’re in such good condition.
There are 3 “levels” of preventing cardiovascular disease:
Primordial
Primary
Secondary
“Secondary” prevention is AFTER you have a heart attack or stroke and manage to survive. That’s when a cardiologist visits you in the hospital, and tries to get you to take the meds necessary to stop any more plaque from accumulating.
Sounds pretty stupid to wait until this point right? Yet it’s the first time most people finally get what they need to stop plaque accumulation from adding to their heavily clogged arteries.
It’s done this way because at this point, insurance / government accountants calculate its finally worth to paying for meds needed to (hopefully) prevent another very expensive heart attack.
“Primary” prevention. There are clear guidelines, treating people based on their LDL levels and “10 year risk”. The obvious weakness here is it doesn’t think beyond the next ten years, and many risk factors (Like PED use) aren’t in the risk formula. Now doctors can put someone into a higher risk group based on factors not included in the formula, so they more aggressively lower LDL, but the reality is most doctors don’t even follow the existing guideline, and it’s extremely rare to find one who goes beyond them. So basically, medicine does a terrible job at primary prevention, and it’s rare for them to even consider doing something until someone’s over 40. Why wait for decades of heart disease to develop first? Because at 40, instead of 20, that patient might have a heart attack in the next 10 years, before that doctor retires.
Finally the highest, leading edge standard, Primordial prevention. Preventing cardiovascular disease (cvd) before it develops. The standard applied by the worlds leading preventative cardiologists, and the one used for the wealthy where only the science is followed, and resources aren’t limited. CVD has been found I children as young as 8. In the Korean war, 23 year old soldiers were found with heavily clogged arteries.
25 years ago, “primordial prevention”, getting LDL <40 (the absolute ideal) wasn’t possible, the meds (pcsk9) didn’t exist. Below <55 came with the cost of high side effect risk statins. Ezetimibe was side effect free but $500/mo. That’s a lot to impose on someone in their 20s and easy to argue it would be better to wait.
But you’re lucky. Today, it’s a different story. Ezetimebe is $10/mo. Rosuvastatin has very low risk of sides, Pitavastatin has an even lower risk. Odds are overwhelming you could take it for life and never experience any negative side effect.
Taking these two tablets (or one Combo), like a “cardiovascular vitamin” daily, you’ll be embracing the standard that will probably become the norm 20 years from now.
Why accept accumulating plaque when you don’t have to, and can do so without paying a price in side effects, only having to manage the small task of taking a pill or two daily? You have a brand new car, why not keep it perfect with some preventative maintainance, instead of waiting until it’s falling apart and can never be fully restored to original condition?
I realize this may sound extreme or like some unsubstantiated by science fringe approach, but it’s not. Search “Primordial prevention cardiovascular disease” and you’ll immediately discover all the leading cardio organizations are moving in this direction. It’s just not implemented yet, but it will be. For you though, by then the early window of opportunity will be closed.
I’ve attached an easy to read article on the topic if you’re interested in digging further.
