Hgh timing

[ve79]

Hey bros I got a question ? How long do you have to wait after you inject HGH before your workout or is this just bro science I've heard if you take HGH before a workout it is not affected or do I have to wait maybe an hour to hours before my workout I'm asking this because I take my GH in the morning for me it's more beneficial and my days off from work I like to go to the gym early can anybody give any insight on this question

 

[BigDadd7]

Hey bros I got a question ? How long do you have to wait after you inject HGH before your workout or is this just bro science I've heard if you take HGH before a workout it is not affected or do I have to wait maybe an hour to hours before my workout I'm asking this because I take my GH in the morning for me it's more beneficial and my days off from work I like to go to the gym early can anybody give any insight on this question

There are so many different anecdotal reports. It seems everyone has a different response.

I think 95% of the benefit comes from just taking it, and worrying about timing is just majoring in the minors. Take it when it's convenient.

I do intermittent fasting. I don't eat after 5pm until 8:30 or 9:00 the next morning. I take mine at ~5:00 am and enjoy the lypolysis.

 

[Ghoul]

If it’s resistance, which benefits from the anabolic effects IGF-1, timing isn’t important because IGF has a long half life and remains stable over the entire day.

If it’s aerobic, in a fasted state, which benefits from GH (before it gets converted to IGF) triggering release of free fatty acids for accelerated fat loss, it starts around an hour after injection and drops close to baseline around 4-5 hours after injection. Once you eat, especially carbs, insulin release blunts the lipolysis and speeds up GH conversion to IGF.

 

[Pundanto]

Depends on your goals I'd say

 

[ve79]

If it’s resistance, which benefits from the anabolic effects IGF-1, timing isn’t important because IGF has a long half life and remains stable over the entire day.

If it’s aerobic, in a fasted state, which benefits from GH (before it gets converted to IGF) triggering release of free fatty acids for My goal isaccelerated fat loss, it starts around an hour after injection and drops close to baseline around 4-5 hours after injection. Once you eat, especially carbs, insulin release blunts the lipolysis and speeds up GH conversion to IGF.

If it’s resistance, which benefits from the anabolic effects IGF-1, timing isn’t important because IGF has a long half life and remains stable over the entire day.

If it’s aerobic, in a fasted state, which benefits from GH (before it gets converted to IGF) triggering release of free fatty acids for accelerated fat loss, it starts around an hour after injection and drops close to baseline around 4-5 hours after injection. Once you eat, especially carbs, insulin release blunts the lipolysis and speeds up GH conversion to IGF.

I'm combining three I use in the morning with 300 test 250 DECA and my goal is to accumulate new muscle tissue this offseason at 3 I use I could feel the numbness in my hands only when I go to bed at night unfortunately but I know at some point I'm probably going to have to increase my HGH but not sure as to how much more I could go to increase muscle tissue

 

[Ghoul]

I'm combining three I use in the morning with 300 test 250 DECA and my goal is to accumulate new muscle tissue this offseason at 3 I use I could feel the numbness in my hands only when I go to bed at night unfortunately but I know at some point I'm probably going to have to increase my HGH but not sure as to how much more I could go to increase muscle tissue

Get your IGF-1 tested and let that be your guide. At a certain point IGF plateaus and increasing GH dose increases sides without IGF going up increasing anabolism.

 

[ve79]

Get your IGF-1 tested and let that be your guide. At a certain point IGF plateaus and increasing GH dose increases sides without IGF going up increasing anabolism.

What is a range to be at?

 

[Ghoul]

What is a range to be at?

Depends on your approach, because you need to manage risk. Especially acromegaly, which is time of exposure dependent, and insulin resistance.

Short term, under 6 months with at least a year break? Some would say as high as you can tolerate the side effects.

Long term or “forever” use? It depends on your age. The IGF “z-score” on your IGF test should not be over 3 for long term safety.

 

[RockyP]

While we always seem to focus on blood glucose (for good reason) with escalating GH dosing, would just throw in a plug for monitoring BP also. My BP never goes above 125 / 70 even on close to a gram of gear, but if I try to increase from 4 to 5 iu of GH even for a few days, my AM blood pressure increases about 15 - 20 points systolic and 10 points diastolic. I do think that it would normalize after a few weeks if I wanted to keep escalating the dosage, but it's not worth it for me. We should all be checking BP regularly even if just on HRT, but just a reminder that GH can also hit the BP pretty hard and pretty quick. I have discussed this with some coaches, all of whom are retired professional open BBers, and they confirmed this in their experience and with their clients, even at "low" doses of 4 to 6 iu.

As for the timing of dosing, I really think it's just easiest and best to take it all at night. There are so many other potent agents for fat loss like GLP-1, clen, etc. GH is a really really expensive fat burner (if that's all you're using it for), best to just take it before bed, enjoy the sleep benefit (if you get it), and let the IGF-1 stay elevated after you start eating.

 

[Ateam2023]

Depends on your approach, because you need to manage risk. Especially acromegaly, which is time of exposure dependent, and insulin resistance.

Short term, under 6 months with at least a year break? Some would say as high as you can tolerate the side effects.

Long term or “forever” use? It depends on your age. The IGF “z-score” on your IGF test should not be over 3 for long term safety.

My recent Igf1 test on 3 ius of lobster gluten free hgh , Age 52 , i know my c reactive is high , narrowing things down through bloodwork

 

[Ghoul]

My recent Igf1 test on 3 ius of lobster gluten free hgh , Age 52 , i know my c reactive is high , narrowing things down through bloodwork View attachment 358055

At least based on this, CRP is below 3, so it’s not catastrophically high, but 2.9 would be pretty bad. You want it under 1, under .5 and you’ve essentially eliminated inflammation as a health risk. But you’ll need HS-CRP to know for sure. IMO one of the most worthwhile “numbers to chase” for a sense of overall well being.

Looks like you have some room in your IGF safety margin if you ever decide to increase, but you’re sitting at a very beneficial “anti aging” level as it is. Z under 2 and you’re pretty much guaranteed no excess growth. Up to 3 is usually no issue, but when you get that close, unless you monitor frequently, it could be easy with UGL for a new batch to push someone above that without them realizing it, and even as little as 4 months could potentially cause soft tissue overgrowth and the beginning of bone changes.

 

[ve79]

At least based on this, CRP is below 3, so it’s not catastrophically high, but 2.9 would be pretty bad. You want it under 1, under .5 and you’ve essentially eliminated inflammation as a health risk. But you’ll need HS-CRP to know for sure. IMO one of the most worthwhile “numbers to chase” for a sense of overall well being.

Looks like you have some room in your IGF safety margin if you ever decide to increase, but you’re sitting at a very beneficial “anti aging” level as it is. Z under 2 and you’re pretty much guaranteed no excess growth. Up to 3 is usually no issue, but when you get that close, unless you monitor frequently, it could be easy with UGL for a new batch to push someone above that without them realizing it, and even as little as 4 months could potentially cause soft tissue overgrowth and the beginning of bone changes.

I been taking Primals black tops for a month and it's pretty strong. I started at 2ius then I went to 4 and it was too strong now I just went back down to 3 two days ago and my hands get numb and forarms are tight but man I love the increase in appetite and I am fuller but that could be just from the caloric surplus and carbs and what's cool is my waist really has not gone up in size however I did gain about 20lb of water Wich doesn't bother me . My strength has been great. I don't think the Deca has quite kick in yet fully with only 4 weeks in also

 

[Ghoul]

I been taking Primals black tops for a month and it's pretty strong. I started at 2ius then I went to 4 and it was too strong now I just went back down to 3 two days ago and my hands get numb and forarms are tight but man I love the increase in appetite and I am fuller but that could be just from the caloric surplus and carbs

If you’ve settled on this dose for the long run it’s the perfect time for IGF-1 testing. It’s cheap.

 

[ve79]

If you’ve settled on this dose for the long run it’s the perfect time for IGF-1 testing. It’s cheap.

I'm trying to find a lab that tests for igf-1 LabCorp is big out here in Illinois but they don't have it . Ghoul I saw that taking GH a for 6 months requires a year off? Is that correct?

 

[RockyP]

I'm trying to find a lab that tests for igf-1 LabCorp is big out here in Illinois but they don't have it . Ghoul I saw that taking GH a for 6 months requires a year off? Is that correct?

are you trying to order direct from LabCorp website? Does your state allow you to use a third party vendor? If so, they will most assuredly have it.

 

[Ghoul]

I'm trying to find a lab that tests for igf-1 LabCorp is big out here in Illinois but they don't have it . Ghoul I saw that taking GH a for 6 months requires a year off? Is that correct?

No, I was speaking about the risk of acromegally from very high supraphysiological levels of IGF.

Early soft tissue changes (enlarged hands, feet, nose etc) can usually revert to normal once you stop.

But worst case scenario, by 6 months, cells in bone can begin to change as a preliminary step towards bone growth. When you take a break, and return to normal levels, this process stops. The problem with a short break, then returning to very high IGF again is that the cells are “primed” and can pick up where they left off, possibly leading to bone growth happening much faster the next time around. It can take a year for them to return to normal” so you can safely do another high IGF cycle again.

 

[Ghoul]

I'm trying to find a lab that tests for igf-1 LabCorp is big out here in Illinois but they don't have it . Ghoul I saw that taking GH a for 6 months requires a year off? Is that correct?

Ultalabtests is cheap and will show you all the labs nearby that can take a blood draw for it. I know there are others as well,

 

[ve79]

Ultalabtests is cheap and will show you all the labs nearby that can take a blood draw for it. I know there are others as well,

Ghoul your the man brother.

 

[Ateam2023]

At least based on this, CRP is below 3, so it’s not catastrophically high, but 2.9 would be pretty bad. You want it under 1, under .5 and you’ve essentially eliminated inflammation as a health risk. But you’ll need HS-CRP to know for sure. IMO one of the most worthwhile “numbers to chase” for a sense of overall well being.

Looks like you have some room in your IGF safety margin if you ever decide to increase, but you’re sitting at a very beneficial “anti aging” level as it is. Z under 2 and you’re pretty much guaranteed no excess growth. Up to 3 is usually no issue, but when you get that close, unless you monitor frequently, it could be easy with UGL for a new batch to push someone above that without them realizing it, and even as little as 4 months could potentially cause soft tissue overgrowth and the beginning of bone changes.

If i push my hgh dose up to 5 ius i get @390 igf, but currently in "granny gear" only doing enough to remain " Relevant" lmao

 

[Deadpool99]

Hey bros I got a question ? How long do you have to wait after you inject HGH before your workout or is this just bro science I've heard if you take HGH before a workout it is not affected or do I have to wait maybe an hour to hours before my workout I'm asking this because I take my GH in the morning for me it's more beneficial and my days off from work I like to go to the gym early can anybody give any insight on this question

I have successfully read the entire 56 page thread. Took me a while...

This has been very eye opening and debunked alot of stuff people used to do cuz they were told to or think is the better option. I am someone who literally strived to split my dosing and strived to get 90mg BG 3 hours post meal to inject my pre-bed HGH, took so much effort, timing, inconvenience to apply and sooo many meds and procedures. I even once did 3 times a day when I first started HGH when going a 10ius blast.

FOUNDATIONAL TRUTHS (Debunked myths)​

Myth	Proven Reality
“GH must be split 3–5× daily for lipolysis”	False — GH lipolysis is peak-driven, not time-under-curve. One large bolus → higher amplitude → more fat mobilization.
“Fasted cardio after GH is required for fat loss”	False — GH itself induces fat oxidation; cardio just amplifies it.
“1.4 IU maxes out lipolysis”	No — linear effect up to at least 0.1 IU/kg (~8 IU for 80 kg).
“You must fast 6–8 h after GH”	Overshot — 2–3 h of low insulin post-injection is sufficient.
“Split dosing prevents water retention”	Opposite — split dosing keeps GH/IGF-1 elevated all day → chronic Na⁺ retention and edema.
“More frequent shots = better muscle gain”	Only true for collagen/joint repair; muscle hypertrophy depends on total IGF-1, which one large dose can match.

WHEN TO INTERVENE​

Sign	Likely cause	Fix
Fasting BG > 5.8 mmol for > 1 wk	Excess total exposure / inadequate XR	Increase Metformin XR dose or add Jardiance
Persistent edema	Chronic exposure (split dosing)	Switch to single AM, add Eplerenone
Poor sleep	Night GH pulse overlap	Move injection to AM
Weak lipolysis	Eating < 2 h post-inj.	Delay carbs ≥ 2.5 h

GH increases peripheral conversion of T4 to T3, may deplete T4.
50 µg T4 on maintenance, 100 µg on higher GH (> 8 IU).
Avoid routine T3; only for short contest preps.

Main TAKEAWAYS (for everyone)​

1. One bolus > split dosing for metabolic health.
2. 2–3 h fasting post-GH is all you need — not 6–8 h.
3. Metformin XR alone controls glucose for most users.
4. 8–10 IU morning injection = maximal fat loss & minimal side effects.
5. Always pair GH with T4 support and RAAS / insulin-sensitizer backbone.
6. Stop chasing near-fasting post-meal BG — only intervene > 6.7 mmol.
7. Less is often more: continuous GH exposure creates chronic IR and puffiness without more gains

I think my approach will be as follows:
8–10 IU single morning injection, wait 2.5 h before carbs, Metformin XR at night, T4 support daily. ( I like Jardiance, eplerenone anyways for it's CV support)

This can hopefully clear some things up.