It's definitely toxic, no getting around that.
I had this conversation with a coach yesterday tho - guys taking 600 - 1000 mg masteron weekly instead of tren are not exactly winning over guys taking 20 mg tren daily. masteron / DHT's wreck HDL also. Lots of us are on aggressive lipid lowering treatment to minimize LDL impact. In terms of the "same results" at least aesthetically I think the only thing that comes close to tren would be a combination of mast and winny, both of which are going to wreck the lipid profile also. Now we can get into the details of all the other tren related toxicities (there are many), but at a dosage of less than 140 mg per week run for 4 to 6 weeks, i'm curious as to what the other options would be to achieve that same look / results. They seem to all include other lipid-killing compounds that are similarly toxic at the effective dosages needed to approximate tren. Hell even 50 mg of winny per day is 2x the total weekly androgen load of a 20 mg daily tren ace.
Problem with masteron is it wont give you aggression and anti gravity effects of tren, I found it makes muscles hard but dry, and at higher dosages both primo and mast suck out a bit too much water and I start losing strength in big lifts (while gaining strength in small lifts like curls). And they crush HDL and mast fucks lipids pretty bad. I only tried masteron once and gave away the rest of the vials to a buddy lol. I hyped him up saying it will mask estrogen sides and make you look ripped and hard, said I looked like I was on tren, he tried it and kept asking if I was sure I gave him the right vials. LOL!
I have been recently been using primobolan, only problem I have had so far with it is PIP and inflammation. I brewed it to 200mg/ml first which is unusable, diluted to 50mg/ml which still gave me elevated CRP levels (and thus other markers follow unfortunately) but I used EO only. Next attempt is in GSO at 50mg/ml. If this doesn't work out then its just test and AI for the first phase of a cycle, then test and NPP, then maybe test/NPP/ment and eventually tren ace as a preworkout. Maybe use EQ instead of primobolan if it gives good enough gains to be worth it. Of course nandrolone is nandrolone but I believe if it is used sparingly it is worth it. Test and primo proved to give better gains than higher test each time for me. Have to admit first that my main goal is not appearance but test/primo/NPP/GH made me look excellent, enough that I wouldn't look back at using trenbolone again
BTW just so you know winstrol is hella toxic, top tier liver toxic stuff. I don't tolerate orals so well unfortunately.
I am also going to follow Ghouls advice for managing lipids with pitavastatin, ezetimibe and bempedoic acid and possibly low dose retatrutide (or dulatide or what it's called). Already use high dose fish oil, 2g niacin, glutathione, metformin. If I could do it all with high dose of test I would but it just isn't enough, and really high doses of test just make me feel crap without increasing the gains, as with all other compounds. So no other option other than doing this whole whacky science project lol.