TRT+ switching from primo to deca kills mood, libido. Curious about other experiences.

TheWestern

New Member
I'm 40, been on TRT for about four years. Like many here, started with a prescriber and then took over myself. I am a licensed medical professional on the clinical side so a little more knowledge than the average bear, but endocrinology is not my specialty. Prescriber had me on test cyp and anastrozole, and when I took over I switched to test-e and primo at about a 1.75 to 1 ratio, always around 175mg T, 100mg primo/week. Functionally this worked well, my mood was good, muscular recovery was fast enough, libido was decent. I am not a hyper responder to testosterone, my total test never got above 700 ng/dl. Bloods always within range, no problem with fats, liver, glucose, etc. Primo, however, gave me huge painful nodules every time I used it. I tried a different source, different injection locations, didn't matter. I've been noticing more joint pain lately after the gym, and decided it was a good excuse to try nandrolone decanoate, since I was really annoyed with the nodules. I knew I'd have to use an AI again if I wasn't on the primo, but I've got a bunch of the anastrozole 0.5mg capsules still laying around. I've been on the test/deca combo for about three weeks now and I'm going to check my hormone levels to see how high my E2 is so I know what my AI dosing should be.

The deca knocked out my joint pain quickly, literally within a week of starting it my joints were feeling better. However, I just have no interest in sex at all, it's not ED, I just don't ever think about it, which I do not like at all. Additionally I feel like my mood is pretty low, I don't feel depressed but I feel mildly annoyed and critical. I know there's a possibility that this is just due to higher E2, but I see people reporting similar sides with deca, even with E2 management. I am not interested in that future.

What are people doing to supplement their TRT other than primo or deca? I'm not trying to get on a cycle here, just look good and feel good. Is the answer just go up to 250mg of test a week and manage the E2? Obviously I know everybody is different and there is no plug and play solution, but I'm interested in what other people have found to be effective in their cruise or TRT level compounds. More information is always better.
 
What was your E2 when you were on TRT with primo? At your doses, i'd have been very low (or zero) and would definitely have sore joints.

Where were the nodules, were you injecting sub-q or IM? Whereabouts? What concentration was your primo and were you mixing it in the same syringe with your test dose?
 
Hey bro, I've had the exact same experience with nandrolone(NPP) even at 50mg/week so I don't even touch it anymore.

Just tried out masteron for the first time and absolutely loved it (although not at a trt dose:)). But I've heard of tons of guys supplementing mast with their trt and say they feel great. I love my low dose primo but once I get back to the US and can get my hands on some mast I'm gonna give that a try on my next cruise.
 
My E2 was usually high twenties on T+primo, however it was 37pg/ml the last bloods I did which was unusual. Not too high obviously and I felt good so I didn't worry about it too much. I was injecting sub-q upper outer glute. I was mixing the primo in the same syringe as the test, the primo concentration was 200mg/ml. I did try warming the primo since I saw it reported that helped with PIP and it seemed to help with injection comfort but the nodules formed regardless.

Edit: looking at my records it looks like I was on 175mg test and 70mg primo when I got that higher E2
What was your E2 when you were on TRT with primo? At your doses, i'd have been very low (or zero) and would definitely have sore joints.

Where were the nodules, were you injecting sub-q or IM? Whereabouts? What concentration was your primo and were you mixing it in the same syringe with your test dose?
 
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Some people just don't get along with Deca.

I know for me Deca by itself with no test is good. Deca with true TRT amount of test, like 100mg or less, is good. Crazy high libido and great gym gains on both.

More than TRT Test with Deca? No fucking bueno. Instant spicy nipples and shit mood.

If you're not down with Deca or Primo your list is pretty short of stuff to add that doesn't aromatize. Mast and EQ is pretty much it. Both have the benefit of controlling E2 sides to some degree for some people. EQ causes anxiety for some folks. Mast is pretty inoffensive. You could try a low dose oral like 5-10mg of Anavar or something.
 
My E2 was usually high twenties on T+primo, however it was 37pg/ml the last bloods I did which was unusual. Not too high obviously and I felt good so I didn't worry about it too much. I was injecting sub-q upper outer glute. I was mixing the primo in the same syringe as the test, the primo concentration was 200mg/ml. I did try warming the primo since I saw it reported that helped with PIP and it seemed to help with injection comfort but the nodules formed regardless.

Edit: looking at my records it looks like I was on 175mg test and 70mg primo when I got that higher E2
I'm going to suggest that your trouble with the primo was a combination of 1) choosing subq 2) the concentration. Point 2 is mitigated somewhat by effectively diluting with the test. Would you be open to trying IM?
 
Back when I started TRT I was pinning IM, it was a mild annoyance but not too bad. My provider had me pinning daily since I have low SHBG so sub-q was far more pleasant and never presented a problem until I added the primo. It sounds like I should find a lower concentration of primo and try that. It makes me wonder how low I can go on the deca and still get the joint lubrication properties. Perhaps leaving low dose deca and adding some primo back in would be the sweet spot.
I'm going to suggest that your trouble with the primo was a combination of 1) choosing subq 2) the concentration. Point 2 is mitigated somewhat by effectively diluting with the test. Would you be open to trying IM?
 
Back when I started TRT I was pinning IM, it was a mild annoyance but not too bad. My provider had me pinning daily since I have low SHBG so sub-q was far more pleasant and never presented a problem until I added the primo. It sounds like I should find a lower concentration of primo and try that. It makes me wonder how low I can go on the deca and still get the joint lubrication properties. Perhaps leaving low dose deca and adding some primo back in would be the sweet spot.
Honestly, i think any primo is going to be bad subq. When you blend with the test in the syringe its diluted the concentration anyway, so should be fine.

I think you might be able to find a sweet spot of the 3 compounds, but i'd say to avoid welts, it might need to be IM. Deca and primo do go well together when blasting. I can't comment on the lower doses you are using.
 
I had something similar recently and proviron really helped a lot. Libido is back, I don’t lose interest in the middle of having sex, and erections are reliable. Initially I was taking 50mg 3x per day but now I’m doing a little less, 25mg 3x per day. My situation is a little different that yours as I think my issue was that I’d used EQ for a few weeks, which caused a multitude of issues for me.
 
I had something similar recently and proviron really helped a lot. Libido is back, I don’t lose interest in the middle of having sex, and erections are reliable. Initially I was taking 50mg 3x per day but now I’m doing a little less, 25mg 3x per day. My situation is a little different that yours as I think my issue was that I’d used EQ for a few weeks, which caused a multitude of issues for me.
I was going to mention this. Just 25 mg twice a day had me feeling great with libido and morning wood. I just took it for a short time and will Add it back but I’m currently trying to get my lipids looking better for a while. For me it felt similar to Mast without edge that Mast put me on.
 
How much deca were you taking? Might have raised your prolactin enough enough to cause this. I've read some folks having some success adding a little primo into the mix since it has a higher AR affinity, I may restore libido in a week or two.
 
I don’t think it’s worth messing with caber unless you’ve confirmed high prolactin with bloodwork. Also it’s unlikely that your prolactin is high unless your estrogen was sky high for a prolonged period of time.
 
I don’t think it’s worth messing with caber unless you’ve confirmed high prolactin with bloodwork. Also it’s unlikely that your prolactin is high unless your estrogen was sky high for a prolonged period of time.
I'm not recommending people to take drugs. But it kinda nagged me so I looked into it. I think taking it chronically at endocrinology levels is relatively safe.

Personally I'd prefer to take it only on cycle.

As for the amount you need to mess up your heart, I'd imagine you'd go broke if you had to pay pharma prices.
1000102549.webp

Source:
Echocardiography and monitoring patients
receiving dopamine agonist therapy for
hyperprolactinaemia: a joint position
statement of the British Society of
Echocardiography, the British Heart Valve
Society and the Society for Endocrinology
 

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Honestly, i think any primo is going to be bad subq. When you blend with the test in the syringe its diluted the concentration anyway, so should be fine.

I think you might be able to find a sweet spot of the 3 compounds, but i'd say to avoid welts, it might need to be IM. Deca and primo do go well together when blasting. I can't comment on the lower doses you are using.
I have no issues with 200mg/ml primo subq. Might be the source that's the issue
 
I'm not recommending people to take drugs. But it kinda nagged me so I looked into it. I think taking it chronically at endocrinology levels is relatively safe.

Personally I'd prefer to take it only on cycle.

As for the amount you need to mess up your heart, I'd imagine you'd go broke if you had to pay pharma prices.
View attachment 360284

Source:
Echocardiography and monitoring patients
receiving dopamine agonist therapy for
hyperprolactinaemia: a joint position
statement of the British Society of
Echocardiography, the British Heart Valve
Society and the Society for Endocrinology
That’s interesting! Although I meant more in terms of, I think it’s unlikely that a relatively small dose of nandrolone increases someone’s prolactin enough to require caber. In which case unless you’ve confirmed high prolactin with a blood test, it doesn’t make sense to use it.
 
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