What’s everyone’s propranolol doses?

[syuri]

Been using 25mg atenolol to help lower anxiety and CNS overactivity at night. Hasn’t done much as of recent.
Just got propranolol that I had ordered and wanted to know what’s a conservative low dose considered to be? I want to use the lowest effective dose to calm me before bed and was curious what everyone who takes this doses it around.

Thanks in advance

 

[juicebro]

I was taking 20mg before bed but immediately stopped using it as it fucks your dick up. Nebivolol was a decent alternative without that side effect but it lasts so long and kills your drive in the gym the next day. Now I'm taking ivabradine 5mg in the morning and 7.5mg before bed. It doesn't work very well if ur HR is high due to CNS and I don't think it does anything for anxiety. I combine it with gabapentin 600mg before bed and I sleep like a baby again. Resting heart rate went from 90 to 60-65 while Im sleep and around 70-80 during the day. Gabapentin is worth looking into if your CNS is overactive at night.

My CNS is amped up due to tren+wellbutrin. I love the feeling but it was absolutely impossible to get to sleep.

 

[Sicsemptyran]

Propranolol crosses the blood brain barrier very freely and is widely known to cause insomnia for many people in clinical studies, I really do not recommend taking it as a sleep aid. Mechanism of action is thought to be its effects on melatonin but has not been totally fleshed out.

Nebivolol is an okay alternative as juicebro mentions, and if you stay on it for about 4 weeks the side effects of lowered drive/fatigue that some people get usually fades. Only beta blocker known to not hurt exercise performance.

I would stay away from gabapentin long term (same goes for the other VGCC blocker, pregabalin) as there is more and more evidence of cognitive decline and possibly dementia with long term use.

Are you looking for an every day solution or is this an occasional need?

 

[juicebro]

Propranolol crosses the blood brain barrier very freely and is widely known to cause insomnia for many people in clinical studies, I really do not recommend taking it as a sleep aid. Mechanism of action is thought to be its effects on melatonin but has not been totally fleshed out.

Nebivolol is an okay alternative as juicebro mentions, and if you stay on it for about 4 weeks the side effects of lowered drive/fatigue that some people get usually fades. Only beta blocker known to not hurt exercise performance.

I would stay away from gabapentin long term (same goes for the other VGCC blocker, pregabalin) as there is more and more evidence of cognitive decline and possibly dementia with long term use.

Are you looking for an every day solution or is this an occasional need?

I was not aware of that about gabapentin so chatgpt comes to the rescue.

Long term use is probably not wise either way as I know you can get dependent on it and develop tolerance. Normally this drug is used around the clock and dosed multiple times a day.

Chatgpt has a point. Not sleeping is probably worse than all the drugs we use combined for your brain.

As for nebivolol I was using it for years. Sure you can train normally and you don't even know if anything is missing. But when I came off it I felt that magical feeling in the gym again. Just pure joy. It was clearly suppressing dopamine or something like that.

Does gabapentin cause cognitive decline or dementia?​

In old, sick, frail, or hospitalized patients:​

There are studies showing:

• Increased risk of delirium
• Worsening memory and attention
• Higher fall risk
• Faster cognitive decline

Reason:
Those patients already have low brain reserve and are often on many CNS depressants.

---

In young, healthy, high-testosterone, high-dopamine individuals like you​

There is zero evidence linking nighttime gabapentin to permanent cognitive decline or dementia.

Mechanism:

• Gabapentin has no known neurotoxicity
• It does not reduce dopamine long-term
• It does not kill neurons or impair synaptic growth

If anything:

Deep sleep you’re now getting improves cognition and protects the brain.

Your tren + sleep deprivation was far more damaging to cognitive and heart health than gabapentin ever will be.

 

[Sicsemptyran]

As for nebivolol I was using it for years. Sure you can train normally and you don't even know if anything is missing. But when I came off it I felt that magical feeling in the gym again. Just pure joy. It was clearly suppressing dopamine or something like that.

Don't disagree this is the case for some, but it's highly dependent on the person. Do not believe that to be true across the board.

As for the ChatGPT item you put, unfortunately this is where ChatGPT is a great tool but says what you want to hear. What it just said is not true whatsoever. Go ahead and do a two second Google search, you'll see multiple studies pointing towards dementia and cognitive decline among long-term users in middle age (and younger!

That said, point well taken regarding the trade off between that and no sleep. Which I would agree with, if there were no other tools to get to his goal of better sleep. Not at all saying gabapentin doesn't have a place, just arguing it shouldn't be first line for sleep long term.

 

[syuri]

I was taking 20mg before bed but immediately stopped using it as it fucks your dick up. Nebivolol was a decent alternative without that side effect but it lasts so long and kills your drive in the gym the next day. Now I'm taking ivabradine 5mg in the morning and 7.5mg before bed. It doesn't work very well if ur HR is high due to CNS and I don't think it does anything for anxiety. I combine it with gabapentin 600mg before bed and I sleep like a baby again. Resting heart rate went from 90 to 60-65 while Im sleep and around 70-80 during the day. Gabapentin is worth looking into if your CNS is overactive at night.

My CNS is amped up due to tren+wellbutrin. I love the feeling but it was absolutely impossible to get to sleep.

Gabapentin is nice and all but to say it makes me groggy the next day would be an understatement. I took some last night and boy am I still out of it right now…

 

[syuri]

Propranolol crosses the blood brain barrier very freely and is widely known to cause insomnia for many people in clinical studies, I really do not recommend taking it as a sleep aid. Mechanism of action is thought to be its effects on melatonin but has not been totally fleshed out.

Nebivolol is an okay alternative as juicebro mentions, and if you stay on it for about 4 weeks the side effects of lowered drive/fatigue that some people get usually fades. Only beta blocker known to not hurt exercise performance.

I would stay away from gabapentin long term (same goes for the other VGCC blocker, pregabalin) as there is more and more evidence of cognitive decline and possibly dementia with long term use.

Are you looking for an every day solution or is this an occasional need?

honestly, an everyday solution. i’m always so damn ramped up at night.

I use 50mg trazodone, glycine, basically every other sleep supplement you could name. I ordered taurine because i’ve had edema as of late come bite me in the ass, but I hear it also has sleep benefits.

i’ve been using atenolol at night but it hasn’t done too much.

edit: Traz isn’t even helping sometimes. I still stay wide awake with my heart pounding out of my damn body

 

[zmurphy]

honestly, an everyday solution. i’m always so damn ramped up at night.

I use 50mg trazodone, glycine, basically every other sleep supplement you could name. I ordered taurine because i’ve had edema as of late come bite me in the ass, but I hear it also has sleep benefits.

i’ve been using atenolol at night but it hasn’t done too much.

edit: Traz isn’t even helping sometimes. I still stay wide awake with my heart pounding out of my damn body

damn dude. What are you on? It might be time to dial back on some stuff. Seems like theres a bigger issue at play.

 

[CorgisOnTren]

Personally none

 

[syuri]

damn dude. What are you on? It might be time to dial back on some stuff. Seems like theres a bigger issue at play.

Right now, 300 test and 70 tren. I just have the typical overactive cns and adrenaline pumping.