is semaglutide the best insulin sensitizing glp?

[white-boyka]

is sema the best for insulin sensitivity out of reta sema and tirz (disregarding its apatite suppression)

 

[BigDadd7]

No

 

[Ghoul]

Tirz is proven best of the three, both in terms of increased insulin sensitivity associated with each pound loss, and independently of weight loss.

Basically, Tirz directly makes fat cells more receptive to storage via GIP (a “sponge” to lower blood glucose) and increasing insulin producing beta cell function,

 

[white-boyka]

Tirz is proven best of the three, both in terms of increased insulin sensitivity associated with each pound loss, and independently of weight loss.

Basically, Tirz directly makes fat cells more receptive to storage via GIP (a “sponge” to lower blood glucose) and increasing insulin producing beta cell function,

so tirz is the best one to run when using gh assuming you can eat enough?

 

[Ghoul]

so tirz is the best one to run when using gh assuming you can eat enough?

Yes. The unknown is whether Reta can produce the same or more sensitivity before appetite suppression becomes too much.

But even small doses of Tirz provide a significant insulin sensitivity boost. It takes a few weeks to fully take effect so you may want to start the Tirz first if you can.

 

[just some dude]

Tirz is proven best of the three, both in terms of increased insulin sensitivity associated with each pound loss, and independently of weight loss.

Basically, Tirz directly makes fat cells more receptive to storage via GIP (a “sponge” to lower blood glucose) and increasing insulin producing beta cell function,

not reta?

 

[Ghoul]

not reta?

As of now, based on the data Tirz has the edge.

Glucagon makes the liver dump glucose into blood. It’s the way the body prevents hypoglycemia. Reta makes that happen continuously. Good for clearing liver fat, maybe offsets the fatigue some people say they feel on Sema/Tirz, but it’s no surprise raising baseline glucose would blunt the GLP/GIP insulin sensitivity improvements at least a little.

 

[ekim]

Don't we want muscle to be insulin sensitive, but not fat????