IGF-1 Help

[Ghoul]

Damn, that's rough, bro. Seeing that IGF-1 result after all that time and product... I'd be pissed too.

I saw you mention a GH serum test – that's what ChemBB suggested to me when I was questioning my stuff. I think it's smart. I'd be curious to see what your levels actually are. I know Civdiv mentioned his IGF-1 was bunk but GH was decent.

Keep us updated, man. Hope it's just a weird reaction for you and not bunk gear.

FYI, if you're female (your name kinda suggests it), don't expect as strong an IGF response to GH as you read from the males here.

The liver takes on a "Male" or "Female" configuration, essentially determined by estrogen exposure. Women produce much more GH than men (stimulated by high estrogen), but make much lower IGF per unit of GH. So normaly the IGF difference between males and females isn't huge (the higher GH in women closes the IGF gap, since there's more of it to generate IGF), but for the same amount of exogenous rHGH, men typically get much higher IGF. If a woman's using oral birth control, IGF levels drop even further, since 80-90% of oral estrogen stays in the liver, further suppressing IGF.

 

[Deadpool99]

What do y’all think is a good timeline to titrate from 4 ius to ur desired dose. For example from 4ius to 12ius.

Do I rly have to titrate 2 ius every 2 weeks, (for example 6ius for 2 weeks then 8ius for the next two and so on…) to minimize water retention. At least this is my purposed plan.

I’d like to minimize it so I can accurately measure weight during a bulk and also who doesn’t want to avoid unnecessary water weight.

 

[AlysiaYeoh]

this whole GH/IGF thing sounds like a freakin' science experiment gone wild! I'm no expert, but it sounds like you're on the right track with the 10iu IM shot and GH serum test. That's what I'd do too.


It's interesting about the calorie deficit and liver issues messing with the GH to IGF conversion. I never really thought about all that. So much more complicated than just pinning and growing, huh?


And the sleep thing? Dude, I feel you. When I'm stressing about something like this, my dreams are always messed up too. Hope that 10iu test gives you some answers. Keep us posted! I'm invested now, haha.

 

[Deadpool99]

this whole GH/IGF thing sounds like a freakin' science experiment gone wild! I'm no expert, but it sounds like you're on the right track with the 10iu IM shot and GH serum test. That's what I'd do too.


It's interesting about the calorie deficit and liver issues messing with the GH to IGF conversion. I never really thought about all that. So much more complicated than just pinning and growing, huh?


And the sleep thing? Dude, I feel you. When I'm stressing about something like this, my dreams are always messed up too. Hope that 10iu test gives you some answers. Keep us posted! I'm invested now, haha.

Thanks brother, I got some high hopes after all the assessments and discussions. Should have the results in a day or two.

 

[Deadpool99]

THANK GOD. I’m so fucking happy. My GH serum level is very good. Way above expectations.

 

[Deadpool99]

For the sake of easily comparing it to loads of other Meso members who did 10 IU IM ~3 hours before blood draw

In about 2 minutes, I found 5 results: average 33 ng/mL, range 28-38

There might be better ways to do the test (with regard to dose, timing, etc) but you wouldn't know what a good result is

For reference I used this post. Seems my response was very strong. IM SO FUCKING HAPPY.

 

[AlexDavis43]

For reference I used this post. Seems my response was very strong. IM SO FUCKING HAPPY.

wait wait it's not an indicator of your "response," it's a crude indicator of how much legit GH you injected

45.3 ng/mL means your GH is good quality but maybe overdosed

"Response" would be assessed by IGF1 levels, which vary widely depending on what else you got going on (so not a good indicator of GH quality unless your response is high, because shit GH can't produce high IGF1)

 

[Deadpool99]

wait wait it's not an indicator of your "response," it's a crude indicator of how much legit GH you injected

45.3 ng/mL means your GH is good quality but maybe overdosed

"Response" would be assessed by IGF1 levels, which vary widely depending on what else you got going on (so not a good indicator of GH quality unless your response is high, because shit GH can't produce high IGF1)

My bad, yes ofc individual response is corrected IGF1, I just so happy I can’t stop typing random shit.

Quality of GH can only be seen through a Janoshik test.

Igf1 probably tanked due to the cut. Will def re-test once in a bulk.

 

[Tomahawk54]

Your serum GH test is great! What gh are you using? Did you mention SSA? I have some 24iu ssa im currently running and my igf1 test cane back not great. 211 igf1.
However, I've been in a caloric deficit for a long 6 month fat loss phase and am just now starting to bring calories back up.
Im going to do a serum gh test this week and see what it comes back as.
I would add this to the equation. Your serum gh looks great. Your hgh must be good.
The igf 1 test only measures your blood serum igf1 that is converted by your liver and does not represent your intramuscular igf1 levels. The intramuscular igf1 levels are accomplished in an entirely different way in the body. Intramuscular or local igf1 is via your autocrine and paracrine system and has nothing to do with serum igf 1.
The local/intramuscular igf1 is what actually causes the anabolic effects that we desire.
We just do not have a way to measure local igf1 via blood test.
So, having a great serum gh test should give you a lot of comfort. The serum igf1 test doesn't really tell you what you need to know. Sure, its a good marker in some ways but it really doesn't matter all that much, the autocrine/paracrine local igf1 is what actually matters.

 

[Deadpool99]

My previous IGF-1 results were on 4ius, I then did 2-4 weeks of 6ius and then 2 weeks on 8ius and then 10 days on 10ius as of these test results.

I also have increased my calories and weighr and am currently lean bulking.

Yet my IGF-1 has been tanking?

@Ghoul any thoughts?

 

[Ghoul]

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My previous IGF-1 results were on 4ius, I then did 2-4 weeks of 6ius and then 2 weeks on 8ius and then 10 days on 10ius as of these test results.

I also have increased my calories and weighr and am currently lean bulking.

Yet my IGF-1 has been tanking?

@Ghoul any thoughts?

Are you in a calorie deficit? “Lean bulking” makes me think you may unwittingly be in deficit. Because the #1 thing that would explain this is insufficient calories / protein.

Are you using any thyroid meds?

Otherwise you’ve got something fucked up going on. Liver issues, severe inflammation, e2 crashed or excessively high.

 

[Deadpool99]

Are you in a calorie deficit? “Lean bulking” makes me think you may unwittingly be in deficit. Because the #1 thing that would explain this is insufficient calories / protein.

Are you using any thyroid meds?

Otherwise you’ve got something fucked up going on. Liver issues, severe inflammation, e2 crashed or excessively high.

I’m currently on 200mcg t4 to recover from my t3 abuse, however I feel like I overshot my t4 and half the cut it in half.

Could that be a determining factor?

 

[Ghoul]

I’m currently on 200mcg t4 to recover from my t3 abuse, however I feel like I overshot my t4 and half the cut it in half.

Could that be a determining factor?

Yeah man that’s almost certainly it.

TSH is so low your thyroid is basically “off”, simulating starvation, increasing GH resistance in the liver, which explains your crashed IGF.

You want TSH to be around 1.