HGH + Retatrutide

[deadbeef]

What’s the source of that data?

The various studies done on both.

Without dose and duration it doesn’t tell us anything,

Read the studies. They tell us a lot.

and it doesn’t explain away the mechanistic action of glucagon making the liver dump glucose into blood,

Actually, it does. It's literally data from the studies showing what reta does for insulin sensitivity. You're conveniently leaving out the part how the glucagon component is combined with the GIP and GLP-1 components, which altogether does some magic to increase insulin sensitivity much more than tirz. They can't be looked at in isolation, and the data backs that up. Lilly hit the magic bullet with reta.

making Rets inferior to Tirz at maintaining lower fasting glucose and insulin sensitivity.

This is a false equivalence. Lower fasting glucose and insulin sensitivity are not one and the same.

 

[zneekah]

Marker	Reta	Tirz
Fasting Glucose	-32 mg/dL	-48.8 mg/dL
HbA1c	-2.0%	-2.46%
Fasting Insulin	-41.6%	-20.9%
HOMA2-IR	-38.9%	-24.0%
Adiponectin	+53%	+23%

I would like the source for this data aswell.

 

[Cimcity]

I can contribute this anecdote to the conversation. I started Reta 5/16/2025. Got my first bloodwork done 7/10 and FBG was 70 (6mg Reta weekly at this time).

Started hgh 4iu in August, along with 250mg test. October bloodwork FBG was 59. 10mg Reta at this time.

I’m not really sure what this means as I have only these two datapoints for my glucose levels. I do often feel weak and faint in the morning before I eat and this seems to be worse on the higher dose of Reta. For what it’s worth.

 

[Y2_dyc]

2 weeks in combining 150mg test/1.5mg Reta/2iu HGH weekly. And although my weight hasn’t moved, the body recomp is real.

Was a little worried with the reported sleep disruption doing the GH pre bed, but for me, my REM and deep sleep have improved significantly.

It’s been 2 years since doing a proper cycle, but I do feel this stack is the closest feeling to a blast in terms of recovery. I must add that I’ve also added MOTS-C 1mg daily just to experiment with. Apart from the PIP, it certainly helps with recovery, endurance and focus.

Got Hyb’s HGH en route, which should be enough for over a years supply at my dosages.

 

[MrBillyMG]

2 weeks in combining 150mg test/1.5mg Reta/2iu HGH weekly. And although my weight hasn’t moved, the body recomp is real.

Was a little worried with the reported sleep disruption doing the GH pre bed, but for me, my REM and deep sleep have improved significantly.

This is probably my biggest improvement. Sleep. It’s been absolutely amazing! 4iu fasted nightly. I strive for 8 hours but I feel fully refreshed at 5-6.5 hours. The first few nights, like clockwork I was up at 2am pissing. It was weird, I’d wake up to piss and be wired, but able to go back to sleep. That’s subsided.

Another crazy visual effect for me has been vascularity. I’m not a veiny person. Not used to pythons going up my arms and down my legs..

 

[Freedom1]

What’s the source of that data? Without dose and duration it doesn’t tell us anything, and it doesn’t explain away the mechanistic action of glucagon making the liver dump glucose into blood, The same glucagon process that clears liver fat more quickly by oxidizing that fat as it produces sugar, makes it worse at insulin sensitivity which is fundamentally a function of insulin exposure time. Carrying the extra blood sugar around that Reta causes via glucagon means more insulin exposure, making Rets inferior to Tirz at maintaining lower fasting glucose and insulin sensitivity.

Said another way:

Reta causes constant glucagon signal → liver releases glucose → blood glucose rises → pancreas secretes more insulin to compensate = higher insulin exposure.

Tirz, by contrast, lowers glucose via GLP-1 and GIP effects without raising glucagon, so less compensatory insulin is needed = lower insulin exposure.

With this said do you believe overall tirz to have the edge since reta is so demanding on the pancreas?

 

[gobig2]

Ok been doing gear since early 20's now lower 50's. Pull labs all the time. My fasted glucose always between 95-105. Now only taking trt with 2ius hgh. Take hgh at night before bed. Thinking of switching hgh to am. Also was thinking of adding in ret or tirz to lower my Blood glucose and get the belly fat down. Which glp would be best for me? Will take the min dosage a week. Thank you

Also have pulled a A1C a few times and its in the good range. However on my labs my fasted glucose high

 

[songsofpyramids]

Ok been doing gear since early 20's now lower 50's. Pull labs all the time. My fasted glucose always between 95-105. Now only taking trt with 2ius hgh. Take hgh at night before bed. Thinking of switching hgh to am. Also was thinking of adding in ret or tirz to lower my Blood glucose and get the belly fat down. Which glp would be best for me? Will take the min dosage a week. Thank you

Also have pulled a A1C a few times and its in the good range. However on my labs my fasted glucose high

You’re pre diabetic according to those numbers and I would absolutely add a glp1. Tirz would be my recommend because I’m skeptical of drugs not approved by the FDA but a ton of people love Reta.

 

[gobig2]

You’re pre diabetic according to those numbers and I would absolutely add a glp1. Tirz would be my recommend because I’m skeptical of drugs not approved by the FDA but a ton of people love Reta.

A1C would say otherwise though. Ive pulled it a few times and its always in the normal range. But yes I dont like my fbg that high. Whats a tirz dose that i can just cruise with each week? Kinda like trt for test

 

[Ilovechinesechemicals]

Hi guys can anyone help me decide which is better to pair with hgh tirz or reta? Currently i have a fasting blood glucose level of 85 and fasting insulin of 3.8. Plan on running hgh around 2-4iu slowly titrating my way up.

I read a lot of these threads and seen a lot of mixed answers with not much trials done on reta so curious to hear your thoughts

 

[gobig2]

Ok been doing gear since early 20's now lower 50's. Pull labs all the time. My fasted glucose always between 95-105. Now only taking trt with 2ius hgh. Take hgh at night before bed. Thinking of switching hgh to am. Also was thinking of adding in ret or tirz to lower my Blood glucose and get the belly fat down. Which glp would be best for me? Will take the min dosage a week. Thank you

Also have pulled a A1C a few times and its in the good range. However on my labs my fasted glucose high

@Ghoul

 

[Endeavor Fitness]

Hi guys can anyone help me decide which is better to pair with hgh tirz or reta? Currently i have a fasting blood glucose level of 85 and fasting insulin of 3.8. Plan on running hgh around 2-4iu slowly titrating my way up.

I read a lot of these threads and seen a lot of mixed answers with not much trials done on reta so curious to hear your thoughts

Honestly, if I were you, and felt this way. I mean if you didn't know which one to use. Start out with one, run it for a while. Come off, and then run the other. With Lab work done, before and after, each one.

After all, we are our own Guinea Pigs. I mean carefully sort through the information, and if you still feel that way, that's what I would do. I started out on Tirz because Reta wasn't really out like that. Then jumped on Reta to see what it is like.

To me, I can run either one for insulin/glucose control with GH. But an added safety measure, I take an SGLT 2 (jardiance) with my shot. I like Reta better because I can do recomps better, my muscles stay fulller, I can eat more carbs, etc.. To me it's a better one for ppl who workout, just my opinion, and from my trainees standpoint because of the preservation of muscle factor. Overall weight loss, I think Tirz is better, to me. That's just my take on which is better.

 

[setters]

I realize what the "science says" but i just couldn't eat, i lost like 3.5 lbs in two weeks and just didn't even want food. I really liked the bg benefits , but couldn't hang

That will wear off. You could start with longer periods between doses or use even less. Once you're on it for a few months you'll tolerate it better. Also if you mean you couldn't eat because of no motivation, you could just force yourself to eat on it, that low of a dose shouldn't be having a major impact on digestion. Lastly are you sure the BG improvements aren't just from not eating? Again, that low of a dose of reta is not going to have a meaningful impact on glucose.

 

[Ilovechinesechemicals]

Honestly, if I were you, and felt this way. I mean if you didn't know which one to use. Start out with one, run it for a while. Come off, and then run the other. With Lab work done, before and after, each one.

After all, we are our own Guinea Pigs. I mean carefully sort through the information, and if you still feel that way, that's what I would do. I started out on Tirz because Reta wasn't really out like that. Then jumped on Reta to see what it is like.

To me, I can run either one for insulin/glucose control with GH. But an added safety measure, I take an SGLT 2 (jardiance) with my shot. I like Reta better because I can do recomps better, my muscles stay fulller, I can eat more carbs, etc.. To me it's a better one for ppl who workout, just my opinion, and from my trainees standpoint because of the preservation of muscle factor. Overall weight loss, I think Tirz is better, to me. That's just my take on which is better.

Hows your blood work after running both reta and tirz with gh? Would you say one is better than the other or the results similar?

 

[Endeavor Fitness]

Hows your blood work after running both reta and tirz with gh? Would you say one is better than the other or the results similar?

My blood work as far as A1C went, I would give the edge to tirz. That because on Reta, I'm allowed to up my carb count, where tirz the appetite suppressant was so strong I was held to 1 solid meal and a bunch of protein shake.

Also, when I was on Tirz, I was rotating between berberine and metformin after meals. So tirz had my blood work as far as glucose markers so good, I was in the hospital for a short stay. They did bloodwork, and they told me to hold off on the metfromin because my A1c was like 4.9. And honestly (because of genetics and BB eating lifestyle), I've always went between pre-diabetic and touching the clinical definition of diabetes.