MESO-Rx
Anabolic Steroids
E4 and m10 new peptides ?
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Randomsmith
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Endostatin , inhibiting endothelial cell migration seems like a bad thing unless you actively have a tumor your trying to get rid of. New blood vessels help with healing wounds by delivering oxygen and nutrients to those areas. Inhibited endothelial cell migration could lead to delayed wound healing and chronic wounds. Endothelial cell migration is a key step in angiogenesis/neurogenesis which if inhibited could cause a whole host of other issues such as inadequate capillary density and poor oxygen delivery.
Now since where on a bodybuilding form , it could also lead to fibro-adipose replacement . This is where normal functional tissue , most often muscle or myocardial cells , are progressively replaced by a combination of fibrous tissue(collagen rich scar tissue) and adipose tissue (fat cells) . This causes non functional , non contractile tissue taking over the affected area leading to a loss of strength, function and potential complications like ARRHYTHMIAS OR WEAKNESS. The opposite of what we are trying to achieve on this form. I don’t think anyone here needs to do anything that could potentially cause more problems for their heart.
On the other hand angiogenesis is essential to the growth of tumors and their survival as stated in the paper below. So if you have a tumor that’s gonna kill you , obviously the risks would outweigh the benefits. And it’s not like it inhibits it a little bit , it inhibited the number of human vessels by 95% on day 20.
I know you your talking about e4 but as it’s derived from Endostatin it does the same. It’s just a fragment of endostatin which of course is a natural inhibitor of angiogenesis. Some research suggests that as a fragment it dosnt have the same suppressive effects as Endostatin itself but there really isn’t enough research to know for sure . It has been linked to reduced cell apoptosis (cell death) in vivo.
Personally , I wouldn’t risk it. But with all experimental peptides your never gonna have enough research to make a true informed decision, there’s always risks . I’m not sure about the other one you mentioned but I’ll look into it and post another comment if I find anything
Now since where on a bodybuilding form , it could also lead to fibro-adipose replacement . This is where normal functional tissue , most often muscle or myocardial cells , are progressively replaced by a combination of fibrous tissue(collagen rich scar tissue) and adipose tissue (fat cells) . This causes non functional , non contractile tissue taking over the affected area leading to a loss of strength, function and potential complications like ARRHYTHMIAS OR WEAKNESS. The opposite of what we are trying to achieve on this form. I don’t think anyone here needs to do anything that could potentially cause more problems for their heart.
On the other hand angiogenesis is essential to the growth of tumors and their survival as stated in the paper below. So if you have a tumor that’s gonna kill you , obviously the risks would outweigh the benefits. And it’s not like it inhibits it a little bit , it inhibited the number of human vessels by 95% on day 20.
I know you your talking about e4 but as it’s derived from Endostatin it does the same. It’s just a fragment of endostatin which of course is a natural inhibitor of angiogenesis. Some research suggests that as a fragment it dosnt have the same suppressive effects as Endostatin itself but there really isn’t enough research to know for sure . It has been linked to reduced cell apoptosis (cell death) in vivo.
Personally , I wouldn’t risk it. But with all experimental peptides your never gonna have enough research to make a true informed decision, there’s always risks . I’m not sure about the other one you mentioned but I’ll look into it and post another comment if I find anything
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Randomsmith
New Member
M10 hasn’t even had any clinical studies . They are all preclinical meaning on mice and human cells. It’s even more risky than e4. Theres no way of knowing what it could do to humans as it’s never even been tested on them. Unless I’m missing something I can’t find a single one.
Anyways . It reduces lung fibrosis in mice and inflammation in the lungs. Prevented or reversed damage caused by lung conditions like systemic sclerosis-related interstitial lung disease and silica-induced pulmonary fibrosis .reduced harmful thickening of lung walls. Inhibits the TGF-B1 pathway , which is a driver of fibrosis. Lowers collagen production in cells that create scar tissue (fibroblasts) without effecting normal levels.
Again all in studies of mice or cells from what I can see. Another one that has potential but needs way way more research before I’d use it. You can usually get paid for trying experimental drugs in trials . Don’t be the Guinea pig.
Anyways . It reduces lung fibrosis in mice and inflammation in the lungs. Prevented or reversed damage caused by lung conditions like systemic sclerosis-related interstitial lung disease and silica-induced pulmonary fibrosis .reduced harmful thickening of lung walls. Inhibits the TGF-B1 pathway , which is a driver of fibrosis. Lowers collagen production in cells that create scar tissue (fibroblasts) without effecting normal levels.
Again all in studies of mice or cells from what I can see. Another one that has potential but needs way way more research before I’d use it. You can usually get paid for trying experimental drugs in trials . Don’t be the Guinea pig.
Thanks for the in-depth information, I was just asked by someone to find some literature on them as his dad is old and I know he’s suffering from some type of lung disease. Thanks again man
Randomsmith
New Member
no problem. I know I’m new here but I’m trying to find places to comment where I be able to help.
There really isn’t enough literature on m10 to make an informed decison. But it has shown benefits in human cell research and on mice for lung scaring and stopping harmful thickening of the lung walls.
But again , compounds can radically change when going from mice to humans . There’s been many many cases of meds that looked great and they get to clinical trials and show horrendous side effects on humans. You just never know. I wish your friends dad well and honestly if he’s really sick from it or god forbid dying , I’d probably try anything that even has a small chance of helping.
Goodluck man
Thanks a lot mate . Do you know of anything that as been used to help people in his situation? I’ve searched but no avail. I’m in the uk and meds here are on the nhs
Randomsmith
New Member
Do you know what kind of lung disease? It would really all depend on that. And I’m not a doctor and not trying to give medical advice but if you know what lung disease he has that would help narrow down options .
Unfortunately most of the time the meds a doctor can prescribe are the best option even when they can’t cure the disease . There’s a reason a lot of these peptides aren’t approved by the fda. If drug companies knew a peptide would cure a disease , they’d be trying to push it through clinical trials and get it patented and on the market asap. Just for the profits it would bring , especially if there is no other drug that treats that disease.
Vikingo
Member
Drug companies don’t want to cure diseases, there’s way more money to be made treating diseases. The whole system is set up to keep people sick and treat diseases with never ending treatments. They don’t look at the root causes of any disease as they’re not interested in curing disease. They make obscene amounts of money selling people drugs for life.
Randomsmith
New Member
So explain Solvadi which 95% of the time cures Chronic Hepatitis C. It’s gotten some negative press because of the insanely high cost.
If a drug company can find a cure for a disease they will patent it and charge you higher prices to make up for the fact that you won’t be a “repeat customer” . I get the hate for big pharma, i really do, but there is many cases of the pharmaceutical industry releasing cures for diseases like all the new Hep c treatments i mentioned above .
You also have Zoliflodacin approved by the fda in December 2025 as a single dose treatment for drug resistant gonorreha (which sounds like a nightmare) . Contepo approved in November 2025 for uncomplicated UTIs. Rezafungin (2023) approved for candidemia (Candia spp in the bloodstream). CASGEVY is a gene therapy given one time to sickle cell patients which stops painful sickle episodes. The FDA almost never uses the word cures either. They use terms like durable responses , long-term remission or “functional cures”.
So there is certainly drugs for cures being released but your right about the pharma industry just looking for profits. I just believe that they can make the same profits curing conditions by releasing them at a much higher cost.
Sorry for all the edits .
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Vikingo
Member
I agree there are exceptions and that is certainly one of them!
Copd and fibrosis. Cheers buddy, I know he’s probably getting the best medicines already but a friend asked me to into it
Randomsmith
New Member
Sorry for all the edits I have insane adhd and always go back to add more information to posts instead of just posting it all once.
If you want a white pill for the day since we are constantly bombarded by black pill shit , the FDA is close to approving more gene therapies for other diseases since they have shown gene therapy already works . Beta Thalassemia a blood disorder which causes your body to produce less hemoglobin has shown to be cured by gene therapy and is close to approval. Many patients don’t need gene therapy infusions anymore making it atleast a functional cure.
My favorite one by far is gene therapies curing inherited blindness! It’s not really widely known but the FDA has already approved gene therapies for partial vision restoration. But the new ones are looking to cure inherited blindness fully. Some CAR-T therapies wven have cured certain blood cancers.
Randomsmith
New Member
Hm well I don’t want to get in trouble on here and this isn’t medical advice but Thymosin Beta-4 has been shown to reduce inflammation, promote tissue regeneration in the heart, lung , liver and skin. Specifically related to fibrosis it suppresses fibroblast over activation which is what causes fibrosis in the first place and also it encourages normal cell migration. It does have some human studies and is actually one of the most researched regeneration peptides. It’s Not fda approved though.
Believe it or not bpc-157 has shown benefits for fibrosis but it was all pre clinical studies ; not on humans. The only other one I could think of besides the two you mentioned is maybe Relaxin and relaxin based peptides. That’s another one that’s only preclinical but it has been shown to break down excess collagen and has anti fibrotic properties through G protein coupled receptors and specifically the relaxin family peptide receptors (RXFP).
RXFP1 activation is key to achieving the anti fibrotic effect. When Relaxin or Relaxin memitic peptides are injected they would bind to RXFP1 which in theory should send the cells a GPCR signal basically saying stop creating scar tissue. Inside the cell RXFP1 increases a molecule called cAMP A messenger molecule that tells the fibroblasts to stop overworking stop making so much collagen (scar tissue) . The last way is Relaxin blocking the fibrosis driving , TGF-B signal (scar tissue creating signal) should again , in theory , stop fibroblasts from becoming myofibroblasts.
I tried to make it the least technical as I could but biology is tricky and I suck at simplifying things. I just don’t like recommending things without explaining why I think they’d help. I hope I could be of some help.
E4 peptide fragment is being investigated because it can supposedly reverse fibrosis altogether. It is indeed derived from Endostatin (which is itself a fragment of Collagen type XVIII) but it does not do what you’re describing. The fragment activates matrix metalloproteinases (MMPs) that degrade scar tissue. The body naturally activates MMPs when repairing an injury, which is why not every cut you get turns into a scar. In cases of large scars, the body assesses that the additional energy expenditure isn’t worth it and leaves the scar in place. With E4, it pushes the body to continue repairing the injury by degrading the scars.
