How "bad" is my kidney function? Safe to continue cycle?

[initialize]

Been on a cycle of test + primo + tren at 600, 200, 200 respectively for the past 2 months.

Bloodwork looks good overall but have some borderline kidney markers:

Creatinine 1.35 (slightly elevated)
BUN 14
EGFR 70
Cystatin C 1.1 (slightly elevated)


Was hoping to run the cycle another month -- think it's safe to do? Or should I stop, or at least stop the tren?

 

[explodingHeart]

Why not go on TRT for a few months and see if Cystatin c gets lower? And check UACR.

Personally I'd pull the plug if cycstatin c ever goes above .9

 

[BP_6]

Not awful, but keep an eye on it. How is your blood pressure? How long have you been on anabolics? Approximately how old are you? Is your bodyweight under control?

 

[initialize]

Not awful, but keep an eye on it. How is your blood pressure? How long have you been on anabolics? Approximately how old are you? Is your bodyweight under control?

I'm 35, been on TRT for 5 years with various blasts since then. Blood pressure is always around 120/80. I'm 220 pounds, about 11% bf

 

[BP_6]

I'm 35, been on TRT for 5 years with various blasts since then. Blood pressure is always around 120/80. I'm 220 pounds, about 11% bf

OK. Thanks for the info. Just keep an eye on it. Might want to look into jardiance a bit. It seems to be helping a lot of people out myself included.

 

[BabaJagga]

i just had cystatinine c at 1.27, creatinine at 105 tested. 750 test, 4iu gh and 50mg anadrol for last 3 weeks.
tested at week 2 of anadrol

ive pulled the plug, removed even test for 2 weeks and will cruise for 3-4 months. i plan to retest cyst. c togeather with other kidney markers, urine test and hope for the best.

i would say you dont wanna do dmg to them, that smells of serious problem in future.

 

[nyss]

The blood work isn't bad. Are you taking creatine? Your numbers are easily solved with more hydration. Will settle down once your cycle's done

 

[explodingHeart]

i just had cystatinine c at 1.27, creatinine at 105 tested. 750 test, 4iu gh and 50mg anadrol for last 3 weeks.
tested at week 2 of anadrol

ive pulled the plug, removed even test for 2 weeks and will cruise for 3-4 months. i plan to retest cyst. c togeather with other kidney markers, urine test and hope for the best.

i would say you dont wanna do dmg to them, that smells of serious problem in future.

Did cystatin c ever come back down?

 

[BabaJagga]

Did cystatin c ever come back down?

not sure yet, this is second week of no test so far. i will retest in few weeks again, its all very recent.

 

[initialize]

The blood work isn't bad. Are you taking creatine? Your numbers are easily solved with more hydration. Will settle down once your cycle's done

Yea taking creatine too

 

[1Megaman]

Yea taking creatine too

Do you also eat a lot of red meat?

 

[bananafeet]

What about your other markers like potassium, sodium, urea etc

 

[initialize]

Do you also eat a lot of red meat?

Usually about one meal a day of red meat

What about your other markers like potassium, sodium, urea etc

All of that is good

 

[nyss]

In that case don't sweat the labs.

 

[BigMike305]

When I take creatine my creatinine jumps up and falsely elevates. I typically need to wait like two or three weeks to let it clear my system before it normalizes again

Also typically helps to take 2 days off training before pulling labs

What cycle were you running when you got original labs ?

 

[LoremIpsum9921]

i just had cystatinine c at 1.27, creatinine at 105 tested. 750 test, 4iu gh and 50mg anadrol for last 3 weeks.
tested at week 2 of anadrol

ive pulled the plug, removed even test for 2 weeks and will cruise for 3-4 months. i plan to retest cyst. c togeather with other kidney markers, urine test and hope for the best.

i would say you dont wanna do dmg to them, that smells of serious problem in future.

You problably know it and I don't mean to scare you, but some damage will probably be permanent. Nephrons sadly cannot regenerate (for now). Luckily, as long as the eGFR is above a certain range no problems will most likely arise and the decline of eGFR can be well managed.
Even if cystatine c comes down, I would skip any harsh drugs on your kidneys for the future.

I had acute kidney injury from rhabdo last year with a CPK > 40k and my creatinine did rise by 0.4 points for some weeks, but cystatine c stayed normal at 0.72 and was never elevated.

For OP: I don't understand why the other ones say that an elevated cystatin c is not bad. That's the case for creatinine, since it heavily affected by muscle mass, weight lifting, protein intake, creatin supplementation, but an elevated cystatin c means most of the time that the kidneys are taking damage and there's no way to regenerate the kidneys.
Even if the markers come down again, the damage will still be there, just that some other nephrons are now working twice as hard to compensate the damage.

 

[bananafeet]

You problably know it and I don't mean to scare you, but some damage will probably be permanent. Nephrons sadly cannot regenerate (for now). Luckily, as long as the eGFR is above a certain range no problems will most likely arise and the decline of eGFR can be well managed.
Even if cystatine c comes down, I would skip any harsh drugs on your kidneys for the future.

I had acute kidney injury from rhabdo last year with a CPK > 40k and my creatinine did rise by 0.4 points for some weeks, but cystatine c stayed normal at 0.72 and was never elevated.

For OP: I don't understand why the other ones say that an elevated cystatin c is not bad. That's the case for creatinine, since it heavily affected by muscle mass, weight lifting, protein intake, creatin supplementation, but an elevated cystatin c means most of the time that the kidneys are taking damage and there's no way to regenerate the kidneys.
Even if the markers come down again, the damage will still be there, just that some other nephrons are now working twice as hard to compensate the damage.

My cystatin C was slightly elevated at 1.05 on a cycle with HGH. When I came off it went to 0.82.

I think cystatin C can be influenced. A better check would be urine ACR.

My urine ACR came back very low (good).

 

[LoremIpsum9921]

My cystatin C was slightly elevated at 1.05 on a cycle with HGH. When I came off it went to 0.82.

I think cystatin C can be influenced. A better check would be urine ACR.

My urine ACR came back very low (good).

Interesting. A quick glance at two studies shows that cystatin c production can stimulate in mouse adipocyte tissue

https://www.sciencedirect.com/science/article/pii/S0303720718303575

Conversely, growth hormones can lower cystatin c in humans

Impact of Growth Hormone on Cystatin C - PMC

Cystatin C (CysC) is an alternative marker to creatinine for estimation of the glomerular filtration rate (GFR). Hormones such as thyroid hormones and glucocorticoids are known to have an impact on CysC. In this study, we examined the effect of ...

pmc.ncbi.nlm.nih.gov

But it seems it's difficult to relate this to HGH bodybuilder dosages.

All these parameters together included ACR, kidney ultrasounds or even just GFR calculated with a tracer would of course the best bet to evaluate the kidney health

Probably a wise idea to take an SGLT2 Inhibitor and manage the blood pressure well. Furthermore, just some interesting fact: Both can lower eGFR, while being nephroprotective, since less pressure means less filtered blood, thus more creatinine and cystatin c in circulation. Conversely, high blood pressure can temporarily increase eGFR, while damaging the kidneys over time. If you managed really aggressively on cycle your blood pressure and take additionally an SGLT2 inhibitor, eGFR could come out lower, while a heavy temporary blast could lead to an artificially higher eGFR while damaging your kidneys.

 

[BabaJagga]

You problably know it and I don't mean to scare you, but some damage will probably be permanent. Nephrons sadly cannot regenerate (for now). Luckily, as long as the eGFR is above a certain range no problems will most likely arise and the decline of eGFR can be well managed.
Even if cystatine c comes down, I would skip any harsh drugs on your kidneys for the future.

I had acute kidney injury from rhabdo last year with a CPK > 40k and my creatinine did rise by 0.4 points for some weeks, but cystatine c stayed normal at 0.72 and was never elevated.

For OP: I don't understand why the other ones say that an elevated cystatin c is not bad. That's the case for creatinine, since it heavily affected by muscle mass, weight lifting, protein intake, creatin supplementation, but an elevated cystatin c means most of the time that the kidneys are taking damage and there's no way to regenerate the kidneys.
Even if the markers come down again, the damage will still be there, just that some other nephrons are now working twice as hard to compensate the damage.

Interesting. A quick glance at two studies shows that cystatin c production can stimulate in mouse adipocyte tissue

https://www.sciencedirect.com/science/article/pii/S0303720718303575

Conversely, growth hormones can lower cystatin c in humans

Impact of Growth Hormone on Cystatin C - PMC

Cystatin C (CysC) is an alternative marker to creatinine for estimation of the glomerular filtration rate (GFR). Hormones such as thyroid hormones and glucocorticoids are known to have an impact on CysC. In this study, we examined the effect of ...

pmc.ncbi.nlm.nih.gov

But it seems it's difficult to relate this to HGH bodybuilder dosages.

All these parameters together included ACR, kidney ultrasounds or even just GFR calculated with a tracer would of course the best bet to evaluate the kidney health

Probably a wise idea to take an SGLT2 Inhibitor and manage the blood pressure well. Furthermore, just some interesting fact: Both can lower eGFR, while being nephroprotective, since less pressure means less filtered blood, thus more creatinine and cystatin c in circulation. Conversely, high blood pressure can temporarily increase eGFR, while damaging the kidneys over time. If you managed really aggressively on cycle your blood pressure and take additionally an SGLT2 inhibitor, eGFR could come out lower, while a heavy temporary blast could lead to an artificially higher eGFR while damaging your kidneys.

My cystatin C was slightly elevated at 1.05 on a cycle with HGH. When I came off it went to 0.82.

I think cystatin C can be influenced. A better check would be urine ACR.

My urine ACR came back very low (good).

ive found out that GH could raise cystatinin c without dmg. i did not dig more into this topic, i stopped all the drugs.

hopefully it will be okay. i plan to do
ultrasound of kidneys to check if im good for another round. wont be takin tren for sure... i would like to use var but... i can live without that.

but with gh use, my cystatinin c rise.

 

[bananafeet]

Keep in mind all androgens are kidney toxic. Testosterone being the least because the estrogen it is a prohormone for is an antioxidant and helps with the ROS produced.

This is why in all animals males have worse eGFR later in life...

Vigorous Steve covered an interesting study where stanozolol was actually less kidney toxic than boldenone in rats.