To microdose Reta og not?!

[Bammdk]

BB community likes to microdose. Doctors and AI experts says once a week or receptor overload.

What are you in to?

I did ED and now E5D. Way more RHR increase on E5D. But not sure if more power.
Actually I think, I like ED microdose better!?

 

[Elektrobot]

It might depend on what your goals are

When I started reta I downloaded an app called shotsy to track the dose and half life and make notes on how I was feeling

I tried it micro dosed ED, EOD, E3D.... and never got hungry. I wasn't eating. I got flat. Low exertion in my training. In the shotsy app my levels were always just above 2

I went to using 2mg/weekly, then upped to 4mg weekly and feel much better. I still had no appetite the first 4-5 days after a shot, but could eat more in the last 2 days

So I synced this with a carb cycling plan to match my training and it has worked well.

I'm not using it for weight loss. I was curious about the other benefits like insulin sensitivity, lipid panel improvements....

I started GH about 3 months after reta, and have had consistent BG and a1c. I can't prove its because of the reta, but I don't necessarily want to stop reta to find out.

 

[adrenalytic]

BB community likes to microdose. Doctors and AI experts says once a week or receptor overload.

What are you in to?

I did ED and now E5D. Way more RHR increase on E5D. But not sure if more power.
Actually I think, I like ED microdose better!?

All the microdosers think they're smarter than the biochemists that developed the drug which is intended to be taken once a week. I'm not that arrogant. I do weekly.

 

[Avoalon]

BB community likes to microdose. Doctors and AI experts says once a week or receptor overload.

What are you in to?

I did ED and now E5D. Way more RHR increase on E5D. But not sure if more power.
Actually I think, I like ED microdose better!?

what seems to work the best for me is 2 times a week

 

[DeJa1991]

BB community likes to microdose. Doctors and AI experts says once a week or receptor overload.

What are you in to?

I did ED and now E5D. Way more RHR increase on E5D. But not sure if more power.
Actually I think, I like ED microdose better!?

Your resting heart rate increased due to the higher weekly load between days 7 and 5. Personally, I gradually increased my dose from 2.5mg e7d to 2.5mg e3d. Each reduction increased the effect. I’ve tried increasing the dose before but I didn’t tolerate it. So higher frequency is for me the way to go before increasing the dose.

 

[Bammdk]

It might depend on what your goals are

When I started reta I downloaded an app called shotsy to track the dose and half life and make notes on how I was feeling

I tried it micro dosed ED, EOD, E3D.... and never got hungry. I wasn't eating. I got flat. Low exertion in my training. In the shotsy app my levels were always just above 2

I went to using 2mg/weekly, then upped to 4mg weekly and feel much better. I still had no appetite the first 4-5 days after a shot, but could eat more in the last 2 days

So I synced this with a carb cycling plan to match my training and it has worked well.

I'm not using it for weight loss. I was curious about the other benefits like insulin sensitivity, lipid panel improvements....

I started GH about 3 months after reta, and have had consistent BG and a1c. I can't prove its because of the reta, but I don't necessarily want to stop reta to find out.

You felt better on 4mg vs 2mg?
Will you be Micro og Weekly dosing in the future?

 

[Avoalon]

It might depend on what your goals are

When I started reta I downloaded an app called shotsy to track the dose and half life and make notes on how I was feeling

I tried it micro dosed ED, EOD, E3D.... and never got hungry. I wasn't eating. I got flat. Low exertion in my training. In the shotsy app my levels were always just above 2

I went to using 2mg/weekly, then upped to 4mg weekly and feel much better. I still had no appetite the first 4-5 days after a shot, but could eat more in the last 2 days

So I synced this with a carb cycling plan to match my training and it has worked well.

I'm not using it for weight loss. I was curious about the other benefits like insulin sensitivity, lipid panel improvements....

I started GH about 3 months after reta, and have had consistent BG and a1c. I can't prove its because of the reta, but I don't necessarily want to stop reta to find out.

Based on my research I think the RHR going up because of the constant glucagon antagonizing

 

[adrenalytic]

Based on my research I think the RHR going up because of the constant glucagon antagonizing

It's a combination of all the receptors being hit and increasing sympathetic tone. All GLP-1 s raise RHR. It's just more pronounced in reta because of the glucagon agonism which, by the way, is nearly immeasurable under 4 mg. Lilly stopped using 2 mg control groups because of this.

In short, the RHR increase is a feature not a bug. Higher RHR = increased energy demand = greater fat loss.

 

[sushak]

The way I see it they have formulated semaglutide for daily administration as a pill and it works which is effectively the same as injecting smaller amounts daily, so no harm in doing it.

 

[Elektrobot]

You felt better on 4mg vs 2mg?
Will you be Micro og Weekly dosing in the future?

Yes, I feel better on 4mg. I don't think it was designed to be on 2mg for very long. Maybe just as a tolerability dose before going up.

I saw a theory somewhere recently that it doesn't start working on your glucagon receptors until 6mg. I'm going to go up to 6 on my next shot.

We don't know the balance of the drugs components, but seeing that theory made me realize it would be silly to think it worked equally on all 3 receptors at the same time and same dose. Maybe more ='s different effects.

I won't be micro dosing it in the future

 

[Elektrobot]

semaglutide

Reta isn't sema

But it is interesting that using the oral every day created a worsened result vs weekly injection.

Why does every day work less?

Seems like daily isn't optimal for sema either. Having a daily pill for some people is a great option. But probably not for our interests here.

 

[Elektrobot]

by the way, is nearly immeasurable under 4 mg. Lilly stopped using 2 mg control groups because of this.

Saw that also. I'm going to 6mg next shot

 

[ParquetPatquet]

Once a week for me, that was the intended use. Trials show that's been pretty effective, so good enough for me. Some people do twice a week to minimize side effects.