Accutane permanent cure?

[2ndchancesNK]

Personally, I don’t believe high doses of Accutane are necessary. It takes time for Accutane to clear acne and the difference between 40 and 80mg shouldn’t matter aside from potential side effects.

I’d recommend starting with 40mg to address the acute phase of the acne. Once a slight improvement is noticed, reduce to 20mg which are quite tolerable. After some time, you could even switch to every other day dosing.

You’re actually not off here at all. Million ways to approach using this drug it seems.

I read a study awhile back with 4 groups that I think went something like this — 1mg/kg ED, 1mg/kg EOD (or 1st ten days of the month, can’t remember), 20mg ED, 20mg EOD were the groups. The study found that 1mg/kg was the most effective until week 8 of the study, but it found that the 1mg/kg group and 20mg ED group had practically similar results at week 16. I will have to dig deep for this one. This study was looking at initial clearance, as opposed to relapse rates though.

However, if we are discussing minimizing rate of relapse, it’s apparent that the higher the daily dose, in combination with higher cumulative dose, and even time spent on the drug after initial clearance are all factors in minimizing relapse rates. Now, obviously, some get lucky and don’t even touch the 120-150mg/kg cumulative dose and never get acne again. Some need to go far beyond that cumulative dose for initial clearance in some cases. Location of the acne, severity, and individual dose response clearly play a role clearance and prevention of subsequent relapse.

 

[explodingHeart]

Any know what happened to Ghoul?

 

[BendigoShafter]

Sadly, no.

"Vaporized. Blown out to sea."

 

[AllbrandNew]

Any know what happened to Ghoul?

I thought homie said he was traveling at the beginning of the year, but I haven't gone back to see if I could find that post or anything. I could very well be misremembering, as it do be like that sometimes.

 

[JustJake]

You’re actually not off here at all. Million ways to approach using this drug it seems.

I read a study awhile back with 4 groups that I think went something like this — 1mg/kg ED, 1mg/kg EOD (or 1st ten days of the month, can’t remember), 20mg ED, 20mg EOD were the groups. The study found that 1mg/kg was the most effective until week 8 of the study, but it found that the 1mg/kg group and 20mg ED group had practically similar results at week 16. I will have to dig deep for this one. This study was looking at initial clearance, as opposed to relapse rates though.

However, if we are discussing minimizing rate of relapse, it’s apparent that the higher the daily dose, in combination with higher cumulative dose, and even time spent on the drug after initial clearance are all factors in minimizing relapse rates. Now, obviously, some get lucky and don’t even touch the 120-150mg/kg cumulative dose and never get acne again. Some need to go far beyond that cumulative dose for initial clearance in some cases. Location of the acne, severity, and individual dose response clearly play a role clearance and prevention of subsequent relapse.

Exactly, the problem with EOD is higher recurrence of relapse. The problem with moderate daily dosing is time to reach cumulative dose while still dealing with mild or worse sides. To me, EOD only makes sense if someone is ultra sensitive to sides or after clearance when they are trying to extend their time on isotretinoin to the 2-3 month mark after resolution, particularly if they have already gone to the higher end of the cumulative dose.

 

[bizzy8240]

i can’t remember the numbers of how much to take per day per kg but I was around 230lbs at the time and I’ve taken two courses of accutane. I will start by saying 100% this is THE BEST thing to take for acne. Any type of acne including steroid induced. I actually took my second course whilst on cycle and it cleared up and gave me nearly spotless skin whilst I was on cycle. I took 40mg ED for around 2 months. And then 60mg for another 3/4 months ish. It also makes you less prone to acne for life. You can take it a lot longer tho. 1 year and even up to 2 years if you want flawless results. but tbh I didn’t like being on them. They’re pretty harsh on your body and they made me feel tired and depressed. But I don’t regret taking it at all. I’m way less prone to acne now. Even when I run cycles I don’t really get acne at all. I get the occasional little spot but it usually goes within like a day or two. If you suffer from acne and want to run multiple cycles without worrying I would defo recommend doing a course of it. Just beware of the potential sides. I was very dry (eyes, nosebleeds from dry nose, dry joints/joint pain) and the biggest one was my depression feeling (which I never ever thought i would experience as I’ve never felt like that whilst been on any drug or in my life. Any questions or anything about my experience with that just ask! Happy to help

 

[YIBUTI_]

I should have outlined that, so thanks for asking. I ran the Accufine for the course and opted for the Tretiva for the maintenance since at 5mg it was almost like getting the 40mg Accufine for 1/2 price and each box will last way longer at the maintenance dose. Per mg it sure isn't cheaper but that was my dumb logic for changing lol.

You'll absolutely be happy with the results as they come. The girls have commented on how soft/smooth my skin is (aside from the dry spots that popped up here and there) and I was only using moisturizer at night and after a shower. The bulk of the face dryness went away about 2/3 of the way through the course, which was a surprise to me.

do you think its worth getting real pharma for double the price? i mean its already cheap so it would be 90usd accufine vs tretiva real pharma 180usd but yeah if accufine is 100% good then i don't see why i should pay double, but some people said about maybe underdose or smth

 

[bigforyouben]

do you think its worth getting real pharma for double the price? i mean its already cheap so it would be 90usd accufine vs tretiva real pharma 180usd but yeah if accufine is 100% good then i don't see why i should pay double, but some people said about maybe underdose or smth

If I didn't have it covered by insurance I would 100% use accufine. If I had it to do over again I'd probably do accufine instead of hassling with monthly doctor visits and refills. Underdosing is most likely temperature degradation, so order before it gets hot in India. And accufine is real pharma.

 

[AllbrandNew]

do you think its worth getting real pharma for double the price? i mean its already cheap so it would be 90usd accufine vs tretiva real pharma 180usd but yeah if accufine is 100% good then i don't see why i should pay double, but some people said about maybe underdose or smth

They are both 'pharma' just different brands as far as I know. The Accufine def works, and most that have run it, I think, used that specifically. If you're at all concerned, run the Tretiva. Get enough to run whatever course you plan, plus a bit to be sure the first go round. You won't miss the extra costs a year from now if you opt for one over the other.

I will be running the Tretiva at 5mg as a maintenance dose, but also have decided to taper down the Accufine as I come off so I'll be over the 220mg/kg threshold by a bit anyways. The extra 40mg boxes I have will probably get frozen for just in case.

 

[YIBUTI_]

If I didn't have it covered by insurance I would 100% use accufine. If I had it to do over again I'd probably do accufine instead of hassling with monthly doctor visits and refills. Underdosing is most likely temperature degradation, so order before it gets hot in India. And accufine is real pharma.

damn it is, it pops up in 1mg, didnt know that, thank you!

 

[YIBUTI_]

They are both 'pharma' just different brands as far as I know. The Accufine def works, and most that have run it, I think, used that specifically. If you're at all concerned, run the Tretiva. Get enough to run whatever course you plan, plus a bit to be sure the first go round. You won't miss the extra costs a year from now if you opt for one over the other.

I will be running the Tretiva at 5mg as a maintenance dose, but also have decided to taper down the Accufine as I come off so I'll be over the 220mg/kg threshold by a bit anyways. The extra 40mg boxes I have will probably get frozen for just in case.

yeah ill probably go for Accufine since its pharma too haha, thank you guys

 

[thomasruss12]

I'm sure someone has addressed this in the past, but wondering if anyone has personal experience. I get bad back and chest acne on minor cycle of 500mg test. I've heard some mixed reviews of whether accutane can truly cure you if you re-expose to androgens after you've had a full cumulative dose of accutane. So here's the question. If planning a new cycle do you:

1. Complete the "curative" course of accutane with no androgen exposure. Try a cycle a few months after completion.

2. Proceed with cycle during the "curative" course of accutane.

My last question is how many have done the full cumulative dose and relapsed when they went back on cycle?

 

[Psy-chonaut]

I'm sure someone has addressed this in the past, but wondering if anyone has personal experience. I get bad back and chest acne on minor cycle of 500mg test. I've heard some mixed reviews of whether accutane can truly cure you if you re-expose to androgens after you've had a full cumulative dose of accutane. So here's the question. If planning a new cycle do you:

1. Complete the "curative" course of accutane with no androgen exposure. Try a cycle a few months after completion.

2. Proceed with cycle during the "curative" course of accutane.

My last question is how many have done the full cumulative dose and relapsed when they went back on cycle?

I've run 19000mg - and apparently it wasn't a cure for me, thinking of taking/starting a 2 course but this time only around 12 -14 grams....

- A bit scared, cuz the first round just k!lled me, in all sorts of ways and aspects...

 

[imthankful]

1. Complete the "curative" course of accutane with no androgen exposure. Try a cycle a few months after completion.

2. Proceed with cycle during the "curative" course of accutane.

My last question is how many have done the full cumulative dose and relapsed when they went back on cycle?

To my understanding being on cycle does not negate any of the overall effects, but rather could make it appear not to be as efficient due to new spots forming.

I am on day 7, up to 160mg split dose currently, on 400test 150npp. My back and shoulders are night and day already. Of course be mindful of your body while combing the two; hydration, liver support, omegas, skin, eye, nose upkeep.

Can’t speak on completion as I just started, there are a lot of studies out there. Passing 200mg/kg is correlated with much less relapse rates. Some show past 220-240mg/kg does not provide exponentially lower rates, but one study up to 280(i believe) had very low relapse rates. I will prob be doing 260mg/kg, 24.5g total, or 240mg/kg depending how I feel towards the end.

 

[butter_s girl]

I've run 19000mg - and apparently it wasn't a cure for me, thinking of taking/starting a 2 course but this time only around 12 -14 grams....

- A bit scared, cuz the first round just k!lled me, in all sorts of ways and aspects...

Maybe up the anti-oxidants. ROS are major downside from aas and upping anti ox helped me alot. Havent run the isotret course yet.

 

[Psy-chonaut]

Maybe up the anti-oxidants. ROS are major downside from aas and upping anti ox helped me alot. Havent run the isotret course yet.

It doesn't help on these deep 'Cyst' mf'ers - don't get that many on my back anymore, but they do grow on the back of my head + back of the neck right now..... Annoying as F

 

[imthankful]

Maybe up the anti-oxidants. ROS are major downside from aas and upping anti ox helped me alot.

Cool one i’ve used in the past when I had fatty liver was dragons blood, I used cultivate elevates product. 2,897,110 ORAC score vs turmerics 102,700 ORAC score

Foods that score high in an antioxidant analysis called ORAC may protect cells and their components from oxidative damage

 

[imthankful]

It doesn't help on these deep 'Cyst' mf'ers - don't get that many on my back anymore, but they do grow on the back of my head + back of the neck right now..... Annoying as F

Tried Adapalene?

 

[Psy-chonaut]

Tried Adapalene?

No only a big run of Iso - but that k!lled them off for approx. a year...

So I know it works to an extent....

 

[imthankful]

No only a big run of Iso - but that k!lled them off for approx.

19g total, what’s your weight?