Distubing - text loss... another story..
So I have been recently motviated to reitterate my diatrobe and re-education of the practicing medical community...
But the bottom line is that there is not a technical article out there these days describing SHBG as the "delivery Method for homrones to tissue". What FUKIN VALUE DOE FREE T HAVE - other than its nice to know ya got some left over...?
The other day I was going round in my head and noting how silly I must look to bio-science technical if even observed. As this quest could readily be viewable with the tools I have used here. Still, i dawns no me that common medical docs and the like still appear to COMPLETELY HAVE MISSED THE BOAT. And it appears to be inherently intended due to the training method in form as applied to analysis and diagnosis methods employed. In short, keep them stupid to some degree so that they can grasp and apply their job. I'm digressing negatively and perhaps again shoving my size 12 in my mouth, so I stop on that analysis trail there. But in short what has prompted my re-visit of this notion was talking to a doc the other day who simply advised that High Free T is "Good". Rediculous... The truth is that he does not really care. He is only operating by the methods to which the community has employed. For him to venture beyond that in though process would border opening the ever philosophical and scientific RESEARCH DOOR, which he has no time for to function effectively based on the standard methods current. The post by JakeZ noting the short life of free T in plasma as well.
As a general premise EVERYONE seems to view Free T as the Mecca of utilized homones, when in fact its nothing more than proof of life. I hear over an over again the worthlessness of testosterone as bound to SHBG. This can not be the case. The ROLE of SHBG is to deliver fuel to biological cells. The hormone which it chooses to involve with is a function or portion of the payload delivered. The actual testosterone which serves as value to the human body is in fact the Testosteroine which is bound to protien, which is either SHBG or ALBUMIN. The free T is simply what is not picked up and used, but PROOF there is excess thus there is enought for normal function. Where the corrolation that higher Free T as a strick positive comes from - I can not gather in text on wrap my brain around. So please help me if I fell off the boat and dont know it.
Consider (2) Primes as a hormonal interaction of Testosterone.
1. Androgens supplied to Muscle, bone, brain, etc.
2. Estrogens supplied to Muscle, bone, brain, etc.
The KEY is that they are not supplied, they are derived there. Testosterone is supplied and ONLY BOUND TESTOSTERONE, at least from a FEEDING or "Biological Feeding Process".
I will consider FAT & MUSCLE for this discussion as the body's (2) far opposites in refernce as to the being the most strickly involved with a particular hormonal derivative generated (androgens or estrogens).
So now, further subset the Testosterone interaction with tissue as such:
1. Muscle - a) Testosterone interacting with muscle for normal process or work.
b) And testosterone supplied to muscle for GROWTH or Tissue generation; either by developmental normal growth stages, or the potential GH release in the GYM - The HOLY GRAIL - new muscle tissue created ( Hint: This dont happen on the cables or nautty)
2. FAT - a) Testosterone interacting with FAT/Adipose tissue in normal function and based on sheer cell count. The normal amount of calories delivered to maintain current fat levels.
b) Testosterone interacting with FAT as a growth and addition of FAT storage. You have to wonder does a "Holy Grail" of Fat tissue cell count exist, in that can fat cells actually increase beyound GENETICALLY INTENDED Counts. I bet it can..!
But THE POINT IS - That when it comes to the value of the hormone testosterone with reference to normal bioloical action in tissue, ITS ACTUALLY THE BOUND TESTOSTERONE THAT SERVES....! I would speculate that whether Free Testosterone as a entity of short life span serves any purpose at all could be up to debate.
So you have the old premise (Bro-Science) that muscle is associated with Androgens and FAT is associaed with estrogens. Yes, the testosterone when applied to the muscle or Fat VIA THE SHBG OR ALBUMIN then spins off the derivative hormones (androgens or estrogens and their subsets).
NOTES:
An Intesting study would be:
What are the diffenences in folks with homonal imbalances to extremes. The OTHER DIFFERENCES. I think the bottom line is that the body will DEMAND what it wants FOOD WISE, which now defines the hormonal derivative pattern. But FOOD for energy being the MASTER SET. Therefore the result will be the same every time. Which is the sacrafice of the inundated system based on the demand on the one in need. AKA - Fat guys will get fatter and have even more estrogens and just to feed their brains at work.
** Its begs some attention to the point as to which protien which testosterone is servicing DOES WHAT. Meaning, Does Albumin only service higher organs (heart, brain, etc). Could SHBG bound be only servicing muscle and fat?
But along the lines of that study is the point that HORMONE DERIVATIVES from testosterone do indeed wind up in plasma, which can only hold so much at a moment. So what does having a bunch of fat generating estrogens from testosterone do to other areas of the body?
Could it potentially render them starved for calories via the overwhelming excess blood population? Meaning does a brain starve somewhat if excess hormones are interacting with receptors thus blocking the hormones carrying the protien from interacting?
Could it potentially cause cancer via FORCED EXTENDED RECEPTOR INTERACTION with hormones. In short, could a prostate be forced to hold an E2 that it had already produced after gobbling the protien attached to the T, and then have that E2 further mutate/derive to E3 right there in the receptor slot, and simply because there was not enough room in plasma to release?!?
Just what is the value to blood plasma clearance to being properly hydrated? And how much does that importance increase to a person who has excess bodily composistions of either nature, and producing excess amounts of either hormone derivative.? While I suspect it simply boils down to the processing organ (liver or kidney), and thay they can be pushed pretty hard, I would imagine an excess workload is never good and should yield some negative results at a minimum..
***** But BACK ON TRACK***** It would seem that not only is SHBG and ALBUMIN in our bodies NOT NOT NOT put there SIMPLY to PROTECT Testosterone for delivery to the cell (Hard Core Bro-Science). Its Actually the REVERSE. In that SHBG and ALBUMIN REQUIRE TESTOTERONE for the FUELING PROCESS and depeding on the cell TYPE. Thus we have our derivatives and their ACTIONS //// AND CONSEQUENCE perhaps.
ZKT Further mentioned that he may agree with some of my notions being possibly correct with regard to not placing so much stock in serum counts. I dont dare place any words in his mouth or attempt to extrapolate where he may or may not agree. But with regard to serum counts, we are simply taking a MEASUREMENT, and then attempting to CORROLATE it with statistical OBSERVATIONS of OTHER SIMILAR ANIMALS/HUMANS IN ACTION. We have developed a NORM based on these numbers which is a calclation of MEANS & AVERAGES which figures are seen most readily in peers alike, and extremely general to that scope. In short - ALL WE REALLY KNOW THAT 1 ='s LIFE and ZERO ='s DEATH. LOL but seriously. Zero being ABSOLUTE, and "1" ranging up to 1200ng/dl with regard to normal healthy standards. That is until you further QUALIFY the STATISTICAL NUMBERS as they relate to the INDIVIDUAL or SUBJECT - which all vary GREATLY when you really take a look. With REGARD to Doc Jim, It should be "As" it becomes unbound... Which would be the process at which time it is uptaked by a hungy cell. There is no in between. (which Z may have only interrated confusingly, not sure)
With regard to the post by JAkeZ. Does more in serum mean better? NO..! Its about proportional relations vs. real bodily doilogical metabolism. There are many variables to look at. With regard to analysis you would Consider TWO VECTORS. First the QUALITY of the MEASUREMENTS, and Second as how the subject COMPARES to others. The first is poorly utiliized, the second in next to impossible to QAUNTIFY. Therefore ACTIVE medical science (in the docs office) stops with limited certainty. That is the most detail the Can EFFECTIVELY UTILITIZE, and given the context of how the ILLNESS or ISSUE MERITS with GREAT consideration for current POLITICS as SOCIAL STANDARDS APPLIED. In short you are CATTLE...
So your free testosterone is 20 (or whatever) and your TT is 980 for example. This tells you NOTHING. NOTHING... NOTHING>>...
1. What was it an hour ago, 30mins, or even 60 seconds.
2. What are your physiological foundations? Receptor counts? Actual numbers of them in USE...!?
3. It considers nothing as far as you current physiological OPERATING EFFICACY or Efficiency. What happens to YOU under a given WORKLOAD or Point of stress.
4. But in short, WE DONT KNOW (3) IMPORTANT THINGS ABOUT YOU:
a) What is you DEMANDED PRODUCTION RATE? How much TT are your NUTZ producing in a given minute or even one second interval.?
b) Where is the TT going? What is it converting to? To which tissue types? We dont even know if FAT uses TT at a SLOWER RATE than muscle (which I suspect is the case). Further how active or your muscles or fat? Are you just walking around or are you working out every day with a spotter forcing you to work to the point that you a bordering on REDIFINING YOUR GENETIC INTENDED COMPOSITION every afternoon at 4pm? Are you fat, or are you even CURRENTLY GETTING FATTER!?!?
c) Whats the clearance rate? Is your body successfully eliminating everything as it should to make room for new.?
Those are three important points. However, FOR MOST FOLKS, the MAGIC act is accurring in number "(b)" above. Consider the human body is pretty fucking BULLET PROOF. And that bastard can adapt on a fucking DIME>!!! So production ("a." above) I suspect for any "healthy or normal" case under 55 yrs old is GIVEN. The capability is there. And as far as "(c.)" above goes, you know your shit is working right, else you would be yellow, green, and all shades in between - hopefully not blue - lol. So the PROBLEM lies in the middle. This is what I refer to in my mind as the "Nitty Gritty" of the human biological process. For example, SHBG is produced in the liver, so what now if you are straining the shit out of if with excess E elimination, or any hormone elimination, or any FOREIGN Contaminant for that matter, What you ate, did not know you ate, whatever. So now you have an organ which is dutied with with the responsibility of BOTH ADDITION and REMOVAL of biological prime players. *** With that said it makes sense when you consider CAP POINTS or max interactional.involvement rates within the SYSTEM as a whole. Hell, it should make sense that an organ responsible of removal of a factor should also produce a related involved factor. Who else knows better right? Or at least its a good measuring point or "thermostat in action". Fuck all that for now. The bottom line is that we dont know how long hormones are involved at receptors, what influences this, how they may go on to further act throughout the body, and its all further confounded by the body's redundancy in production points; as well as the hormone derivation BACK AND FORTH PROTOCAL which occurs with many homones in the body. So this is the area which is the mystery and will remain one for some time I thiink, or at least untile someone with the brain comes along and develops a super computer with the firmware to process the calculations, BUT ONLY after we have discerned all the valid points of measurement and detemined HOW to properly measure and then STANDARDIZED to this theorhetical calculator...
Examples of complete failures in SINGULAR FACTORS to interpret by:
Take the Numbers I gave above. 1200 TT and Free T of 20. Thats (2) Factors which is better than one. You can create this matrix:
1. Body is producing enough TT to meet demands and enought Free T.
2. Body is working slow or sick today and TT is elevated and LESS is being USED.
3. Body is working harder than usual today and the test was taken at the end of an instand up swing to 1600 even, immediatly throttled down in plasma SUPPLY by CONSUMPTION.
4. Nothing changes on TT and Free T goes up. Perhaps the body is using less Bound T today and the NUTZ Just cant get enought of that production high buzz cause you are such a workout free aerobicaly and normally have to have a bunch, but you watched TV instead.
5. Free T only again, but goes down. You could be using more TT which is forcing to blood to pick up more Free T right off the produciton line thus leaving less. BUT KEY, your boys are currently maxed out so therefore FREE T must reduce. Your RESERVE has been lessened.
6. The list goes on.
I used to preach BASELINES, and getting bloodwork done prior to any attempt to supplement hormones. Then I went through a phase of what the fuck is the point when so many variables and medicine could give a shit from a diagnostic standpoint anyway. but really its better to do so.
The one thing that the current science of TRT can be sure of should be this. The closer the measurement to the SOURCE, the better the proof of failure if there is such a thing as a "Low T Male". The one thing Free T is, is that it is obviously Testosterone that is not picked up by Protien. Still the failure of Actual Demanded Usage Rates again applies, and on.... But it makes sense that if Total T goes up as A REAL DEMAND (not nececsarily measurable), then Free T should Go down, BUT ONLY given that testicular production is nearing top end production potential. So in most folks and Low T males for sure, this scenario should not arrise to offer any accuracy. If you further bring SHBG into the equation and create a "Tri-Matrix", you then would not know any more unless you are measuring SHBG unbound and uninvolved with T (which common sense would indicate they MUST BE), and still all the above variable moot out same - unless you can now get a flow meter on the liver too in order to monitor SHBG production.. And who the fuck even knows where Albumin is sythesized or where it comes from? Do we now bring the digestive tract into play? Or is it strict liver majority also.?
A "Low-T Male" may in fact be a low T male simply because of the fact that he has not andrgen generating factors to create the production of Androgens. In fact, the "low-T Male" is REALLY the "Low-Androgen Male", but society wont dare to go there. Then you might actually be supplying them with the dreaded "Super Criminal Elixer" - Lex Luthor in a bottle - lol... Also a low T male is not only a LowT Male, but He is a "High-E Male" with usual Certainty. So he not only suffers the lack of the luxury on androgens (and really the luxury of what makes them more realically), he is suffering the conserquence of the PAIN of Excess E's. A viscious circle and sort of a dance with the devil and dare to stare a the abyss. And on this occasion the Lure is the Devil's off to let you continue to look, while all along you are sinking further and more irrevokably. FAT is a TRAP that is TIME DEPENDENT indeed...
Enough....
(good) http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9285
(weak) Sex hormone-binding globulin - Wikipedia, the free encyclopedia
(interesting and another topic) Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
(Marketing) SHBG: The Test | Sex Hormone Binding Globulin
(Looks Good) http://jcem.endojournals.org/content/91/12/4764.full (Sex Hormone Binding Globulin: Inhibitor or Facilitator (or Both) of Sex Steroid Action?)
(LOL) AE-3 - Aromatase blocker, SHBG blocker with Estrogen detoxifier (why anyone whould want to "Block" Shbg is beyond me)
(interesting attemp at somehing) Testosterone Basics
(BEYOND) Human variant sex hormone-binding gl... [J Clin Endocrinol Metab. 1998] - PubMed - NCBI
There are a couple of attachments too...
So I have been recently motviated to reitterate my diatrobe and re-education of the practicing medical community...
But the bottom line is that there is not a technical article out there these days describing SHBG as the "delivery Method for homrones to tissue". What FUKIN VALUE DOE FREE T HAVE - other than its nice to know ya got some left over...?The other day I was going round in my head and noting how silly I must look to bio-science technical if even observed. As this quest could readily be viewable with the tools I have used here. Still, i dawns no me that common medical docs and the like still appear to COMPLETELY HAVE MISSED THE BOAT. And it appears to be inherently intended due to the training method in form as applied to analysis and diagnosis methods employed. In short, keep them stupid to some degree so that they can grasp and apply their job. I'm digressing negatively and perhaps again shoving my size 12 in my mouth, so I stop on that analysis trail there. But in short what has prompted my re-visit of this notion was talking to a doc the other day who simply advised that High Free T is "Good". Rediculous... The truth is that he does not really care. He is only operating by the methods to which the community has employed. For him to venture beyond that in though process would border opening the ever philosophical and scientific RESEARCH DOOR, which he has no time for to function effectively based on the standard methods current. The post by JakeZ noting the short life of free T in plasma as well.
As a general premise EVERYONE seems to view Free T as the Mecca of utilized homones, when in fact its nothing more than proof of life. I hear over an over again the worthlessness of testosterone as bound to SHBG. This can not be the case. The ROLE of SHBG is to deliver fuel to biological cells. The hormone which it chooses to involve with is a function or portion of the payload delivered. The actual testosterone which serves as value to the human body is in fact the Testosteroine which is bound to protien, which is either SHBG or ALBUMIN. The free T is simply what is not picked up and used, but PROOF there is excess thus there is enought for normal function. Where the corrolation that higher Free T as a strick positive comes from - I can not gather in text on wrap my brain around. So please help me if I fell off the boat and dont know it.
Consider (2) Primes as a hormonal interaction of Testosterone.
1. Androgens supplied to Muscle, bone, brain, etc.
2. Estrogens supplied to Muscle, bone, brain, etc.
The KEY is that they are not supplied, they are derived there. Testosterone is supplied and ONLY BOUND TESTOSTERONE, at least from a FEEDING or "Biological Feeding Process".
I will consider FAT & MUSCLE for this discussion as the body's (2) far opposites in refernce as to the being the most strickly involved with a particular hormonal derivative generated (androgens or estrogens).
So now, further subset the Testosterone interaction with tissue as such:
1. Muscle - a) Testosterone interacting with muscle for normal process or work.
b) And testosterone supplied to muscle for GROWTH or Tissue generation; either by developmental normal growth stages, or the potential GH release in the GYM - The HOLY GRAIL - new muscle tissue created ( Hint: This dont happen on the cables or nautty)
2. FAT - a) Testosterone interacting with FAT/Adipose tissue in normal function and based on sheer cell count. The normal amount of calories delivered to maintain current fat levels.
b) Testosterone interacting with FAT as a growth and addition of FAT storage. You have to wonder does a "Holy Grail" of Fat tissue cell count exist, in that can fat cells actually increase beyound GENETICALLY INTENDED Counts. I bet it can..!
But THE POINT IS - That when it comes to the value of the hormone testosterone with reference to normal bioloical action in tissue, ITS ACTUALLY THE BOUND TESTOSTERONE THAT SERVES....! I would speculate that whether Free Testosterone as a entity of short life span serves any purpose at all could be up to debate.
So you have the old premise (Bro-Science) that muscle is associated with Androgens and FAT is associaed with estrogens. Yes, the testosterone when applied to the muscle or Fat VIA THE SHBG OR ALBUMIN then spins off the derivative hormones (androgens or estrogens and their subsets).
NOTES:
An Intesting study would be:
What are the diffenences in folks with homonal imbalances to extremes. The OTHER DIFFERENCES. I think the bottom line is that the body will DEMAND what it wants FOOD WISE, which now defines the hormonal derivative pattern. But FOOD for energy being the MASTER SET. Therefore the result will be the same every time. Which is the sacrafice of the inundated system based on the demand on the one in need. AKA - Fat guys will get fatter and have even more estrogens and just to feed their brains at work.
** Its begs some attention to the point as to which protien which testosterone is servicing DOES WHAT. Meaning, Does Albumin only service higher organs (heart, brain, etc). Could SHBG bound be only servicing muscle and fat?
But along the lines of that study is the point that HORMONE DERIVATIVES from testosterone do indeed wind up in plasma, which can only hold so much at a moment. So what does having a bunch of fat generating estrogens from testosterone do to other areas of the body?
Could it potentially render them starved for calories via the overwhelming excess blood population? Meaning does a brain starve somewhat if excess hormones are interacting with receptors thus blocking the hormones carrying the protien from interacting?
Could it potentially cause cancer via FORCED EXTENDED RECEPTOR INTERACTION with hormones. In short, could a prostate be forced to hold an E2 that it had already produced after gobbling the protien attached to the T, and then have that E2 further mutate/derive to E3 right there in the receptor slot, and simply because there was not enough room in plasma to release?!?
Just what is the value to blood plasma clearance to being properly hydrated? And how much does that importance increase to a person who has excess bodily composistions of either nature, and producing excess amounts of either hormone derivative.? While I suspect it simply boils down to the processing organ (liver or kidney), and thay they can be pushed pretty hard, I would imagine an excess workload is never good and should yield some negative results at a minimum..
***** But BACK ON TRACK***** It would seem that not only is SHBG and ALBUMIN in our bodies NOT NOT NOT put there SIMPLY to PROTECT Testosterone for delivery to the cell (Hard Core Bro-Science). Its Actually the REVERSE. In that SHBG and ALBUMIN REQUIRE TESTOTERONE for the FUELING PROCESS and depeding on the cell TYPE. Thus we have our derivatives and their ACTIONS //// AND CONSEQUENCE perhaps.
ZKT Further mentioned that he may agree with some of my notions being possibly correct with regard to not placing so much stock in serum counts. I dont dare place any words in his mouth or attempt to extrapolate where he may or may not agree. But with regard to serum counts, we are simply taking a MEASUREMENT, and then attempting to CORROLATE it with statistical OBSERVATIONS of OTHER SIMILAR ANIMALS/HUMANS IN ACTION. We have developed a NORM based on these numbers which is a calclation of MEANS & AVERAGES which figures are seen most readily in peers alike, and extremely general to that scope. In short - ALL WE REALLY KNOW THAT 1 ='s LIFE and ZERO ='s DEATH. LOL but seriously. Zero being ABSOLUTE, and "1" ranging up to 1200ng/dl with regard to normal healthy standards. That is until you further QUALIFY the STATISTICAL NUMBERS as they relate to the INDIVIDUAL or SUBJECT - which all vary GREATLY when you really take a look. With REGARD to Doc Jim, It should be "As" it becomes unbound... Which would be the process at which time it is uptaked by a hungy cell. There is no in between. (which Z may have only interrated confusingly, not sure)
With regard to the post by JAkeZ. Does more in serum mean better? NO..! Its about proportional relations vs. real bodily doilogical metabolism. There are many variables to look at. With regard to analysis you would Consider TWO VECTORS. First the QUALITY of the MEASUREMENTS, and Second as how the subject COMPARES to others. The first is poorly utiliized, the second in next to impossible to QAUNTIFY. Therefore ACTIVE medical science (in the docs office) stops with limited certainty. That is the most detail the Can EFFECTIVELY UTILITIZE, and given the context of how the ILLNESS or ISSUE MERITS with GREAT consideration for current POLITICS as SOCIAL STANDARDS APPLIED. In short you are CATTLE...
So your free testosterone is 20 (or whatever) and your TT is 980 for example. This tells you NOTHING. NOTHING... NOTHING>>...
1. What was it an hour ago, 30mins, or even 60 seconds.
2. What are your physiological foundations? Receptor counts? Actual numbers of them in USE...!?
3. It considers nothing as far as you current physiological OPERATING EFFICACY or Efficiency. What happens to YOU under a given WORKLOAD or Point of stress.
4. But in short, WE DONT KNOW (3) IMPORTANT THINGS ABOUT YOU:
a) What is you DEMANDED PRODUCTION RATE? How much TT are your NUTZ producing in a given minute or even one second interval.?
b) Where is the TT going? What is it converting to? To which tissue types? We dont even know if FAT uses TT at a SLOWER RATE than muscle (which I suspect is the case). Further how active or your muscles or fat? Are you just walking around or are you working out every day with a spotter forcing you to work to the point that you a bordering on REDIFINING YOUR GENETIC INTENDED COMPOSITION every afternoon at 4pm? Are you fat, or are you even CURRENTLY GETTING FATTER!?!?
c) Whats the clearance rate? Is your body successfully eliminating everything as it should to make room for new.?
Those are three important points. However, FOR MOST FOLKS, the MAGIC act is accurring in number "(b)" above. Consider the human body is pretty fucking BULLET PROOF. And that bastard can adapt on a fucking DIME>!!! So production ("a." above) I suspect for any "healthy or normal" case under 55 yrs old is GIVEN. The capability is there. And as far as "(c.)" above goes, you know your shit is working right, else you would be yellow, green, and all shades in between - hopefully not blue - lol. So the PROBLEM lies in the middle. This is what I refer to in my mind as the "Nitty Gritty" of the human biological process. For example, SHBG is produced in the liver, so what now if you are straining the shit out of if with excess E elimination, or any hormone elimination, or any FOREIGN Contaminant for that matter, What you ate, did not know you ate, whatever. So now you have an organ which is dutied with with the responsibility of BOTH ADDITION and REMOVAL of biological prime players. *** With that said it makes sense when you consider CAP POINTS or max interactional.involvement rates within the SYSTEM as a whole. Hell, it should make sense that an organ responsible of removal of a factor should also produce a related involved factor. Who else knows better right? Or at least its a good measuring point or "thermostat in action". Fuck all that for now. The bottom line is that we dont know how long hormones are involved at receptors, what influences this, how they may go on to further act throughout the body, and its all further confounded by the body's redundancy in production points; as well as the hormone derivation BACK AND FORTH PROTOCAL which occurs with many homones in the body. So this is the area which is the mystery and will remain one for some time I thiink, or at least untile someone with the brain comes along and develops a super computer with the firmware to process the calculations, BUT ONLY after we have discerned all the valid points of measurement and detemined HOW to properly measure and then STANDARDIZED to this theorhetical calculator...
Examples of complete failures in SINGULAR FACTORS to interpret by:
Take the Numbers I gave above. 1200 TT and Free T of 20. Thats (2) Factors which is better than one. You can create this matrix:
1. Body is producing enough TT to meet demands and enought Free T.
2. Body is working slow or sick today and TT is elevated and LESS is being USED.
3. Body is working harder than usual today and the test was taken at the end of an instand up swing to 1600 even, immediatly throttled down in plasma SUPPLY by CONSUMPTION.
4. Nothing changes on TT and Free T goes up. Perhaps the body is using less Bound T today and the NUTZ Just cant get enought of that production high buzz cause you are such a workout free aerobicaly and normally have to have a bunch, but you watched TV instead.
5. Free T only again, but goes down. You could be using more TT which is forcing to blood to pick up more Free T right off the produciton line thus leaving less. BUT KEY, your boys are currently maxed out so therefore FREE T must reduce. Your RESERVE has been lessened.
6. The list goes on.
I used to preach BASELINES, and getting bloodwork done prior to any attempt to supplement hormones. Then I went through a phase of what the fuck is the point when so many variables and medicine could give a shit from a diagnostic standpoint anyway. but really its better to do so.
The one thing that the current science of TRT can be sure of should be this. The closer the measurement to the SOURCE, the better the proof of failure if there is such a thing as a "Low T Male". The one thing Free T is, is that it is obviously Testosterone that is not picked up by Protien. Still the failure of Actual Demanded Usage Rates again applies, and on.... But it makes sense that if Total T goes up as A REAL DEMAND (not nececsarily measurable), then Free T should Go down, BUT ONLY given that testicular production is nearing top end production potential. So in most folks and Low T males for sure, this scenario should not arrise to offer any accuracy. If you further bring SHBG into the equation and create a "Tri-Matrix", you then would not know any more unless you are measuring SHBG unbound and uninvolved with T (which common sense would indicate they MUST BE), and still all the above variable moot out same - unless you can now get a flow meter on the liver too in order to monitor SHBG production.. And who the fuck even knows where Albumin is sythesized or where it comes from? Do we now bring the digestive tract into play? Or is it strict liver majority also.?
A "Low-T Male" may in fact be a low T male simply because of the fact that he has not andrgen generating factors to create the production of Androgens. In fact, the "low-T Male" is REALLY the "Low-Androgen Male", but society wont dare to go there. Then you might actually be supplying them with the dreaded "Super Criminal Elixer" - Lex Luthor in a bottle - lol... Also a low T male is not only a LowT Male, but He is a "High-E Male" with usual Certainty. So he not only suffers the lack of the luxury on androgens (and really the luxury of what makes them more realically), he is suffering the conserquence of the PAIN of Excess E's. A viscious circle and sort of a dance with the devil and dare to stare a the abyss. And on this occasion the Lure is the Devil's off to let you continue to look, while all along you are sinking further and more irrevokably. FAT is a TRAP that is TIME DEPENDENT indeed...
Enough....
(good) http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9285
(weak) Sex hormone-binding globulin - Wikipedia, the free encyclopedia
(interesting and another topic) Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
(Marketing) SHBG: The Test | Sex Hormone Binding Globulin
(Looks Good) http://jcem.endojournals.org/content/91/12/4764.full (Sex Hormone Binding Globulin: Inhibitor or Facilitator (or Both) of Sex Steroid Action?)
(LOL) AE-3 - Aromatase blocker, SHBG blocker with Estrogen detoxifier (why anyone whould want to "Block" Shbg is beyond me)
(interesting attemp at somehing) Testosterone Basics
(BEYOND) Human variant sex hormone-binding gl... [J Clin Endocrinol Metab. 1998] - PubMed - NCBI
There are a couple of attachments too...
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