MESO-Rx
Anabolic Steroids
First day back
- Thread starter stomps
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Prevent the soreness by the following, on day one begin with a 1600mg ibuprofen loading dose followed by 600mg every six hours. The next day start 600mg QID or 800mg TID for the next 7-10 days in addition to loading 40mg of OTC omeprazole (Prilosec, Zegerid) followed by 20 QD for 7-10 days. I've discovered this combination diminishes the M-S soreness considerably while also significantly limiting GI side effects. I would suggest reducing the NSAID dosage by one half if you have documented (by EGD) "gartritis", peptic ulcer disease or have undocumented upper abdominal pain readily relieved by antacids (Tums, Alka Seltzer) or H-2 blockers (Zantac, Axid, Pepcid). If any GI symptoms persist more than 48-72 hours in spite of the PPI's discontinue the ibuprofen OR cut the dose in half.
FYI although the maximum dosage of ibuprofen is 3200mg/day the observed benefit is minimal compared to the increased side effect profile noted with dosages exceeding 2400mg/day!
Moreover well fitting ice packs (bought at Sports Authority as gel inserts for adjustable "knee or shoulder" ice "wraps") work wonderfully, IME.
Welcome back, mate!@
FYI although the maximum dosage of ibuprofen is 3200mg/day the observed benefit is minimal compared to the increased side effect profile noted with dosages exceeding 2400mg/day!
Moreover well fitting ice packs (bought at Sports Authority as gel inserts for adjustable "knee or shoulder" ice "wraps") work wonderfully, IME.
Welcome back, mate!@
Dadgum fine question mate (I am aware of what some forums would lead you to believe such as ..... one forum posted the "catabolic effects of Ibuprofen at a dose of 2400 mg daily will reverse the effects of 500mg of test pinned weekly", absurd!)
However since the pathways of glucocorticoids, are similar in part from a theoretical perspective, the answer is YES, however from a practical/clinical vantage point the answer is ABSOLUTELY NOT. This becomes more apparent after scanning the literature because many of the animal model studies, where an MINIMAL yet statistically significant catabolic or "non-anabolic" effect was demonstrated, used much HIGHER and longer interval dosing of NSAIDs compared to human therapy.
Moreover a PRIMARY contributor to the soreness which develops as a consequence of inadequate conditioning is reduced muscular perfusion (blood flow). The decreased flow directly leads to anaerobic metabolism and the byproduct accumulation of lactic acid. Since myofibrils (actin and myosin) use an ATP dependent calcium influx/eflux for "sliding" (one over the other) to occur, if ATP is limited they become "locked" which causes the soreness! FYI the "natural" or non-ATP dependent position is contraction which is why dead folks are "stiffs". Consequently if returning the gym "requires" NSAIDS your better off because doing so relieves the stiffness by restoring ATP and "unlocking" the muscles. Furthermore, lactic acid is removed and reutilized in the hepatic/renal dependent gluconeogenesis pathway where it's converted to neo(new) gluco(glucose) genesis(birth).
Use those NSAIDS mate if needed and tolerated and your GTG
However since the pathways of glucocorticoids, are similar in part from a theoretical perspective, the answer is YES, however from a practical/clinical vantage point the answer is ABSOLUTELY NOT. This becomes more apparent after scanning the literature because many of the animal model studies, where an MINIMAL yet statistically significant catabolic or "non-anabolic" effect was demonstrated, used much HIGHER and longer interval dosing of NSAIDs compared to human therapy.
Moreover a PRIMARY contributor to the soreness which develops as a consequence of inadequate conditioning is reduced muscular perfusion (blood flow). The decreased flow directly leads to anaerobic metabolism and the byproduct accumulation of lactic acid. Since myofibrils (actin and myosin) use an ATP dependent calcium influx/eflux for "sliding" (one over the other) to occur, if ATP is limited they become "locked" which causes the soreness! FYI the "natural" or non-ATP dependent position is contraction which is why dead folks are "stiffs". Consequently if returning the gym "requires" NSAIDS your better off because doing so relieves the stiffness by restoring ATP and "unlocking" the muscles. Furthermore, lactic acid is removed and reutilized in the hepatic/renal dependent gluconeogenesis pathway where it's converted to neo(new) gluco(glucose) genesis(birth).
Use those NSAIDS mate if needed and tolerated and your GTG
Today was the first day back in the gym in a very long time i'am going to be super sore tomorrow. Its always hard to get back into it after a long break
Enjoy the gains - and the soreness! It's a treat for those who've trained 5+ years. Steroid-like gains without the steroids
Enjoy the gains - and the soreness! It's a treat for those who've trained 5+ years. Steroid-like gains without the steroids
I will for sure
This thread is somewhat old, but if anyone cares the best way to avoid DOMS (delayed onset muscle soreness) is to not overdue it after a long break or a sudden increase in intensity. The cause of DOMS isn't known, but prevention is simple. To avoid DOMS as much as possible, start off with only one workout set at between 50-65% 1RM on ALL exercises your first week, then go up to 65% week two (approximately 12 RM) while alternating 1 workout set for first exercise, 2 for the second, etc. That's in addition to a warm up set for each new muscle group. Then I think you guys know the rest...
509iron
New Member
Love that feeling....just broke off!
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