TRT good for prostate health?

[Millard]

Comments on this please? If true, does this mean TRT-induced hypogonadism should effectively reduce prostate problems in older men?

http://themedialine.org/news/news_detail.asp?NewsID=34738

Dr. Yigal Gat and Dr. Menachem Goren, two experts in male fertility, say they located an enlarged vein that develops as men age that ends up siphoning off testosterone from the testes straight to the prostate where it becomes clogged rather than being distributed to the rest of the body...

He said that testosterone levels inside enlarged prostates were about a hundred times above the normal. Their procedure involves a catheterization performed under local anesthetic only to clear out the varicocele veins. It lasts between 90 minutes and two hours, after which the patient is released. Within a day he can resume their normal lives.

“We know that the testosterone was the cause and the origin that caused the acceleration of the proliferation of the prostate and now we have the good treatment -- and very simple treatment -- that can minimize the growth of the prostate.”

The procedure was originally reported in the German urology journal Adrologia last year, but Gat and Goren waited to announce their success until after clinical trials.

https://twitter.com/#!/RickCollinsEsq/status/184400428895698946

 

[hardasnails1973]

It all comes to down to proper balance of T: E2 ratio, along with SHBG, and DHT factor in.

If a person has testosterone of 600 with e2 of 60 , shbg 20 for prolong number of year there chances may be increased.

You have TT 2000 e2 30 and shbg 30 for prolonged number of years then I would say ones chances are signifcantly decreased in regards to the first scenerio.

Scally please comment.

 

[Millard]

The following study was published in 2009. I couldn't find the relevant one that the article says was published by authors last year.

Prostate cancer: a newly discovered route for testosterone to reach the prostate
Treatment by super-selective intraprostatic androgen deprivation
Y. Gat1, S. Joshua2, M. G. Gornish3
Article first published online: 7 SEP 2009
Prostate cancer: a newly discovered route for testosterone to reach the prostate - Gat - 2009 - Andrologia - Wiley Online Library

Andrologia
Volume 41, Issue 5, pages 305–315, October 2009

Summary
The prostate, an androgen-regulated exocrine gland, is an integral part of the male reproductive system which has an essential function in sperm survival and motility in its long hostile route to meet and fertilise the egg in the Fallopian tube. Testosterone is known to be the key, obligatory regulator of the prostate that promotes the development and progression of prostate cancer (PCa). Yet, the pathophysiological mechanism of PCa remains unclear and its causal relation to serum testosterone has not been established. Here, we report on the discovery of a previously unrecognized route of flow of free testosterone (FT), at a concentration of 130 times the physiological levels, reaching the prostate via the testicular and prostate venous drainage systems, bypassing the systemic circulation. This condition results from the malfunction of the vertically oriented testicular venous drainage system in humans, a phenomenon with a prevalence that increases rapidly with age, which causes deviation of the testicular venous flow from its normal route. Early results of an interventional radiological procedure, super-selective intraprostatic androgen deprivation therapy are discussed. This treatment has resulted in decrease in prostate volume, and serum PSA, with disappearance of cancerous cells on repeat biopsies in five of six patients. Some of the unresolved biological enigmatic questions associated with PCa are discussed. We conclude that pathological flow of FT from the testes directly to the prostate in an extremely high concentration via the testicular-prostate venous drainage systems was identified may explain the mechanism for the development of PCa. We suggest a time-window for eradication of localised, androgen-sensitive, PCa cells. We anticipate that this treatment may retard, stop or even reverse the development of the disease. A mechanism for the evolution of PCa is discussed.

 

[Michael Scally MD]

Gat Y, Gornish M, Heiblum M, Joshua S. Reversal of benign prostate hyperplasia by selective occlusion of impaired venous drainage in the male reproductive system: novel mechanism, new treatment. Andrologia 2008;40(5):273-81. Reversal of benign prostate hyperplasia by selective occlusion of impaired venous drainage in the male reproductive system: novel mechanism, new treatment - Gat - 2008 - Andrologia - Wiley Online Library

The prostate is an androgen-regulated exocrine gland producing over 30% of the noncellular components of the semen and promoting optimal conditions for survival and motility of sperm in the vagina. Benign prostate hyperplasia (BPH) is the most common benign neoplasm in men. Its aetiology is not clear, and therefore, current medical treatments are directed towards the symptoms. Though testosterone is known to be the promoter of prostate cell proliferation, no causal relation between serum testosterone levels and BPH has been found. In this study, we propose a novel and tested pathophysiological mechanism for the evolution of BPH and suggest a tested and effective treatment. We found that in all BPH patients, the one-way valves in the vertically oriented internal spermatic veins are destroyed (clinically manifested as varicocele), causing elevated hydrostatic pressure, some 6-fold greater than normal, in the venous drainage of the male reproductive system. The elevated pressure propagates to all interconnected vessels leading to a unique biological phenomenon: venous blood flows retrograde from the higher pressure in the testicular venous drainage system to the low pressure in the prostatic drainage system directly to the prostate (law of communicating vessels). We have found that free testosterone levels in this blood are markedly elevated, with a concentration of some 130-fold above serum level. Consequently, the prostate is exposed to: (i) increased venous pressure that causes hypertrophy; (ii) elevated concentration of free testosterone causing hyperplasia. We have treated 28 BPH patients using a technique that restores normal pressure in the venous drainage in the male reproductive system. The back-pressure and the back-flow of blood from the testicular to the prostate drainage system were eliminated and, consequently, a rapid reduction in prostate volume and a regression of prostate symptoms took place.

 

[foreveryoung]

I wonder about this too, seems that over the years it was when I was on testosterone or hcg or both that I had off and on problems with my prostate, slower urinary flow, etc..... now that I have been off of everything for some years I just thought about it and my prostate has not caused me any issue at all for years

why is it that when I was experimenting with hrt or testosterone that I had off and on prostate issues?

 

[Millard]

According to this study, it is testosterone produced by testes that leads to prostate problems but NOT necessarily testosterone itself.

So, with introduction of TRT, this dramatically reduces testosterone produced by testes (unless of course you supplement with hCG).

If the authors hypothesis is correct, then wouldn't TRT be a great preventative measure for men to take?

 

[foreveryoung]

According to this study, it is testosterone produced by testes that leads to prostate problems but NOT necessarily testosterone itself.

So, with introduction of TRT, this dramatically reduces testosterone produced by testes (unless of course you supplement with hCG).

If the authors hypothesis is correct, then wouldn't TRT be a great preventative measure for men to take?

maybe other factors come in to play, like dht and estrogen

 

[newbie23]

According to this study, it is testosterone produced by testes that leads to prostate problems but NOT necessarily testosterone itself.

So, with introduction of TRT, this dramatically reduces testosterone produced by testes (unless of course you supplement with hCG).

If the authors hypothesis is correct, then wouldn't TRT be a great preventative measure for men to take?

If his hyp is correct, sounds logical to me.

 

[Handle2]

I wonder about this too, seems that over the years it was when I was on testosterone or hcg or both that I had off and on problems with my prostate, slower urinary flow, etc..... now that I have been off of everything for some years I just thought about it and my prostate has not caused me any issue at all for years

why is it that when I was experimenting with hrt or testosterone that I had off and on prostate issues?

Why did you decide to go off TRT?

 

[zkt]

Could this also be part of the reason that serum T levels decrease with age: a portion of the production is shunted to the prostate instead od the systemic circulation ?
Would be interesting to see if there are studies relating the incidence of BPH and PC to TRT and non TRT groups.
This seems to point to a connection to BPH and PC, which I thought didnt exist, according to many studies.