MESO-Rx
Anabolic Steroids
dnp??
- Thread starter swelty
- Start date
unt0ld
New Member
Is that true or just a rummor?
That's that!
New Member
That's a huge broad generalization. How exactly does it cause birth defects? Who's the carrier, mom or dad or child? Is this chromosonal? You ask me that's a bunch hocus pocus. PROVE IT.--That's that!
FIREFLY
New Member
these days BREATHING causes fucked up kids.
novicebb
New Member
The only damage I have heard and read that dnp may damage is the Mitochondria but nothing on dna but even if that is the case I wouldn't use when I am planning to concieve. I am sure whatever DNA damage that it may cause can be reverse with time after use. But I would love to learn more about this report though.
yea i also have read that it alters the DNP strand ( on message boards ) .... but it dont know if theres any truth about it
MANWHORE
Subscriber
The Women have to be most careful .. MOST .. no MORE careful than men when it comes to putting stuff in their bodies before or when looking for children in future .. I would go on the say that even if a man was ON a DNP cycle at the time he impregnated the women, there would be no problems from the DNP itself but i sure as hell won't be the one to try it and i sure as hell wouldn't recommend it .. Like i said before DNP is not as bad as MANY make it out to be .. Keep hydrated and everything will more than likely be just fine .. Fine meaning no perminant damage to your body but not fine from feeling like total shit
FTT010101
New Member
ok,
Breath...
The reason that this might have been propagated is because of this.... The mitocondria in almost every cell in your body are Miotic (god I hope thats the right word lol... meaning they can and do undergo the fun and exciting process called... tum tum tum! Mitosis! (crowd goes wild)...) Ok.. with that said... its not really a probelem for guys because we take in all this DNP which screws up our electron transport chains with the good ol creation of a hydrogen ion gradient which is leaky of all things... needless to say... our mitocondria get F@#%ed in the A$$ and are no longer very happy. Ok, with that said they continue to function and well, once they are ready they split (mitosis). Since DNP acts on the electron transport chain and not on the DNA of the mitocondria the cell still has a blueprint on how to build another... hence why its able to copy itself. So it copies itself and if dnp is still present it screws up its electron transport chain... so you can see where this is going... ok. Now as a male we can fuck up the mitocondria in our sperm (tails) as much as we flippin please because there will always be more. We produce massive quantities of ... nm, you all SHOULD know this. Women on the other hand are born with a certain number of oocytes (OH-OH-Site) (eggs) ... the speculation is here... aparently we are not certain at this time if the mitocondria's in the eggs are miotic or not (Amiotic... I think thats the word)... the biggest fear I have heard of is infertility... i guess thats a kind of birth defect LOL
... ok, bad joke... whatever. Now if you are thinking that the mitocondrial dna can just be taken from the father... thats where another issue is... aparently the mitocondrial dna can only be passed through the female lines... probobly because upon fertalization (please dont make me go through this)... the Tail (where the sperm has its mitocondria) is lopped off as the head gets taken into the cell... so... no mitocondria from mr. sperm. I just got done reading some interesting research paper on bovine fertilization where they put a die (mitotracker) on the mitocondria of the sperm cell and waited to see if it would be integrated into the zygote... didnt work aparently. Ok... well thats that...
Exhale....
whew!
FTT
Breath...
The reason that this might have been propagated is because of this.... The mitocondria in almost every cell in your body are Miotic (god I hope thats the right word lol... meaning they can and do undergo the fun and exciting process called... tum tum tum! Mitosis! (crowd goes wild)...) Ok.. with that said... its not really a probelem for guys because we take in all this DNP which screws up our electron transport chains with the good ol creation of a hydrogen ion gradient which is leaky of all things... needless to say... our mitocondria get F@#%ed in the A$$ and are no longer very happy. Ok, with that said they continue to function and well, once they are ready they split (mitosis). Since DNP acts on the electron transport chain and not on the DNA of the mitocondria the cell still has a blueprint on how to build another... hence why its able to copy itself. So it copies itself and if dnp is still present it screws up its electron transport chain... so you can see where this is going... ok. Now as a male we can fuck up the mitocondria in our sperm (tails) as much as we flippin please because there will always be more. We produce massive quantities of ... nm, you all SHOULD know this. Women on the other hand are born with a certain number of oocytes (OH-OH-Site) (eggs) ... the speculation is here... aparently we are not certain at this time if the mitocondria's in the eggs are miotic or not (Amiotic... I think thats the word)... the biggest fear I have heard of is infertility... i guess thats a kind of birth defect LOL
... ok, bad joke... whatever. Now if you are thinking that the mitocondrial dna can just be taken from the father... thats where another issue is... aparently the mitocondrial dna can only be passed through the female lines... probobly because upon fertalization (please dont make me go through this)... the Tail (where the sperm has its mitocondria) is lopped off as the head gets taken into the cell... so... no mitocondria from mr. sperm. I just got done reading some interesting research paper on bovine fertilization where they put a die (mitotracker) on the mitocondria of the sperm cell and waited to see if it would be integrated into the zygote... didnt work aparently. Ok... well thats that... Exhale....
whew!
FTT
That's that!
New Member
Outstanding answer FT. Gold star for you for the day.--That's that!
No. Absolutely not. No birth defects, no infertility.
1) There's no reason to think any DNA would be damaged. Mitochondrial ROS reactive oxygen species (free radicals) are actually reduced with DNP usage, not increased. DNP mimics the uncoupling proteins that are naturally found in the mitochondria. I'd say that how mitochondria split has nothing to do with anything here.
2) We know that in just one of the years that DNP was sold, more than 100,000 people took it, primarily women. Neither birth defects nor infertility were ever linked to DNP... only cataracts in a very small percentage of women. Why we all of a sudden think DNP causes birth defects and infertility some 70 years later is beyond me. It doesn't.
To answer the original question, no, there haven't been any real studies on DNP and weight loss since the late 1930's. The newly empowered FDA banned it and that was that.
1) There's no reason to think any DNA would be damaged. Mitochondrial ROS reactive oxygen species (free radicals) are actually reduced with DNP usage, not increased. DNP mimics the uncoupling proteins that are naturally found in the mitochondria. I'd say that how mitochondria split has nothing to do with anything here.
2) We know that in just one of the years that DNP was sold, more than 100,000 people took it, primarily women. Neither birth defects nor infertility were ever linked to DNP... only cataracts in a very small percentage of women. Why we all of a sudden think DNP causes birth defects and infertility some 70 years later is beyond me. It doesn't.
To answer the original question, no, there haven't been any real studies on DNP and weight loss since the late 1930's. The newly empowered FDA banned it and that was that.
That's that!
New Member
Conciliator said:
Here comes the monkey wrench. We're quite fortunate to have to very versed gentlemen on this subject. Please continue...
srch4info
New Member
FTT.... you brought me back to high school biology class when you started talking about "mitosis"
...glad that wasn't one of the classes I slept through
...glad that wasn't one of the classes I slept through
unt0ld
New Member
Yeah thanks for the informative posts guys. keep up the good work.
FTT010101
New Member
while what the concilator says is true... the only thing we arent clear on is if the eggs (since there are a fixed number of them) have miotic mitocondria... so yes.. the fact that mitocondria split in most cells is important. We havent been able to prove it one way or the other... this in no way means there would be birth defects dirrectly because of this... those might be caused by any number of discovered or undiscovered threats/problems. Same goes for infertility... for all we know the woman taking dnp might have been infertal naturaly or from some other cause... there is NO conclusive data one way or another... all theory...and since this drug is long removed from the lime light...there probobly wont be any... By no means is what I wrote above definitive (for example: what I say is the truth and fuck you all if you dont belive me)... its all open to theory and hypothesis. But with all that said... untill we have a definitive answer to the "Are the mitocondria in the oocytes miotic?" it should be filed under the "keep it in the back of your head" catagory.
ok, thats all i gotta say right now
FTT
ok, thats all i gotta say right now
FTT
Are the mitocondria in the oocytes miotic?FTT010101 said:
How does the answer to this question make a shred of difference if DNP doesn't increase ROS?
It doesn't.
Last edited:
FTT010101
New Member
Sure... your answer makes sense... why... why you ask... well
if the mitocondria can split then sure... not a problem
even if they cant... probobly not a problem for the DNA because the dna wont be damaged and will be taken at fertilization and passed along to all the new mito's that will be made for the new baby.
Im not worried about that at all.
But... If DNP causes most of the energy the cell gets from the E.T.C. to be released as heat instead of atp for the cell itself (the cells food), then its goign to cause an increase in heat output by that cell... if the mito cant split then how long is the dnp goign to stay there hanging out in the mito of the egg... if they are taking it long enough then thats going to be a cell that is starved for atp plus who knows if there is a possibility that the egg could denature because of the excess amount of heat.... Im not worried about the mito reproduction when a zygote is formed... im more worried about the woman who takes this for fat on and off for a long period of time (if in fact we find out that the mitocondria's are not miotic)...
FTT
if the mitocondria can split then sure... not a problem
even if they cant... probobly not a problem for the DNA because the dna wont be damaged and will be taken at fertilization and passed along to all the new mito's that will be made for the new baby.
Im not worried about that at all.
But... If DNP causes most of the energy the cell gets from the E.T.C. to be released as heat instead of atp for the cell itself (the cells food), then its goign to cause an increase in heat output by that cell... if the mito cant split then how long is the dnp goign to stay there hanging out in the mito of the egg... if they are taking it long enough then thats going to be a cell that is starved for atp plus who knows if there is a possibility that the egg could denature because of the excess amount of heat.... Im not worried about the mito reproduction when a zygote is formed... im more worried about the woman who takes this for fat on and off for a long period of time (if in fact we find out that the mitocondria's are not miotic)...
FTT
I think you're misunderstanding and misrepresenting how DNP works.
1) It has a 36 hour half life. It's not going to be "hanging around" in any cell for more than a few days after the last dose.
2) It makes ATP production less efficient in a dose dependant manner. At normal doses, you are not making more heat than you are ATP, like you claim. This would require a doubling of metabolic rate (>600mg/day).
3) Regardless, no cell is going to run out of ATP or run low on ATP. The whole reason metabolism increases is to keep ATP levels normal despite the decreased efficiency of energy prodiction. Sure, the ATP/ADP ratio will probably drop a little while you're on DNP, but with the increase in metabolism comes an increase in ATP production to compensate for the drop in efficiency.
4) Body temperature does not increase at lower doses of DNP and only increases by a degree or two at higher doses of DNP (excepting unreasonably high doses) as the body is unable to radiaite the excess heat. There's absolutely no reason to think that any cells in the body, eggs included, are going to die or become damaged from heat.
5) If infertility is a possible side effect, why wasn't it noticed when over 100,000 people took DNP in the 1930's? It just doesn't add up. There's no evidence or reason to think that DNP causes these problems and there is evidence and reason to think that it does not.
1) It has a 36 hour half life. It's not going to be "hanging around" in any cell for more than a few days after the last dose.
2) It makes ATP production less efficient in a dose dependant manner. At normal doses, you are not making more heat than you are ATP, like you claim. This would require a doubling of metabolic rate (>600mg/day).
3) Regardless, no cell is going to run out of ATP or run low on ATP. The whole reason metabolism increases is to keep ATP levels normal despite the decreased efficiency of energy prodiction. Sure, the ATP/ADP ratio will probably drop a little while you're on DNP, but with the increase in metabolism comes an increase in ATP production to compensate for the drop in efficiency.
4) Body temperature does not increase at lower doses of DNP and only increases by a degree or two at higher doses of DNP (excepting unreasonably high doses) as the body is unable to radiaite the excess heat. There's absolutely no reason to think that any cells in the body, eggs included, are going to die or become damaged from heat.
5) If infertility is a possible side effect, why wasn't it noticed when over 100,000 people took DNP in the 1930's? It just doesn't add up. There's no evidence or reason to think that DNP causes these problems and there is evidence and reason to think that it does not.
FTT010101
New Member
I dont belive im missinterpreting how DNP works... everything ive read and heard from my friends who have studdied it in much more detail than I have (Biochem majors... two of them at least) ... the other is my bro (has had to take lots of advanced chem crap for his major)... everything Ive read and heard is exactly how I have stated it here... your points are valid ones and have been taken into my knowlege bank of info pertaining to drugs and bodybuilding. I appreciate all that you have contributed to this thread, thanks! I dont know if I can explain my case any more here though... maybe im just not good at explaining what I mean. 
One last thing though, I do belive that since we have no conclusive information on or pertaining to what has been talked about above with DNP's effect (long and short term) on the human body and no conclusive evidence to support how DNP might Affect the oocytes with regards to everything Ive said above in my previous post that all opinions and stated "truths" be held in speculation... so... you have a choice... Either roll with caution, or... if you are so absolutley certain that without a doubt you are right about what you belive... then roll with that.
I for one error on the side of caution.
FTT
One last thing though, I do belive that since we have no conclusive information on or pertaining to what has been talked about above with DNP's effect (long and short term) on the human body and no conclusive evidence to support how DNP might Affect the oocytes with regards to everything Ive said above in my previous post that all opinions and stated "truths" be held in speculation... so... you have a choice... Either roll with caution, or... if you are so absolutley certain that without a doubt you are right about what you belive... then roll with that.
I for one error on the side of caution.
FTT
