MESO-Rx Exclusive Superdrol's unique characteristics

[MESO-Rx Administrator]

MESO-Rx is pleased to publish the eighth installment in the "Unique Characteristics of Anabolic-Androgenic Steroids" series by @Type-IIx . The article focuses on Superdrol:

Methasterone (Superdrol) is a potent anabolic steroid known for its impressive muscle-building properties and low androgenic effects. However, it is highly hepatotoxic, limiting its use to advanced bodybuilders during contest prep despite limited supporting data.

Methasterone Insights: Unique Characteristics of Anabolic-Androgenic Steroids – Part 8

Learn about Methasterone (Superdrol), a potent anabolic steroid with impressive muscle-building effects but significant hepatotoxicity risks.

thinksteroids.com

 

[Rush]

Curious to hear your view on the comparison between oral vs injectable administration? Are there any differences regarding effectiveness, hepatoxicity or anything else?

I felt that the injectable version felt easier on the system, but I would really like to hear your thoughts on this

 

[Type-IIx]

BOOM - Article dropped!!!

Superdrol is one that I think has a place, albeit a limited one, in the yearly plan. It is most potently antiestrogenic. Dry.

 

[Type-IIx]

Curious to hear your view on the comparison between oral vs injectable administration? Are there any differences regarding effectiveness, hepatoxicity or anything else?

I felt that the injectable version felt easier on the system, but I would really like to hear your thoughts on this

I think that injection is basically equivalent in hepatotoxicity to oral administration. The reason is simply that the angular 17α-methyl attachment increases potency [Superdrol is 17α-alkylated Masteron, so significantly more potent] and half-life to hours rather than seconds. Injectable, non-17α-alkylated AAS are rapidly metabolized by the liver, thus their liver concentrations are comparatively low.

Importantly, all androgens must be metabolized by the liver.

Similarly, I think that injection is basically equally efficacious or anabolic as oral ingestion for the same reasons – these drugs act systemically rather than locally after all.

On balance, it comes down to tolerability: whether Superdrol makes you nauseous when ingested or causes pain and swelling at the injection site with daily pinning. It's basically preference between these tolerability factors that decide.

 

[AlmightyAlpha]

I think that injection is basically equivalent in hepatotoxicity to oral administration. The reason is simply that the angular 17α-methyl attachment increases potency [Superdrol is 17α-alkylated Masteron, so significantly more potent] and half-life to hours rather than seconds. Injectable, non-17α-alkylated AAS are rapidly metabolized by the liver, thus their liver concentrations are comparatively low.

Importantly, all androgens must be metabolized by the liver.

Similarly, I think that injection is basically equally efficacious or anabolic as oral ingestion for the same reasons – these drugs act systemically rather than locally after all.

On balance, it comes down to tolerability: whether Superdrol makes you nauseous when ingested or causes pain and swelling at the injection site with daily pinning. It's basically preference between these tolerability factors that decide.

Any oral vs injectable passes the liver twice. Injectable superdrol is still considered toxic but it only passes the liver once

 

[Type-IIx]

Any oral vs injectable passes the liver twice. Injectable superdrol is still considered toxic but it only passes the liver once

First pass metabolism is practically irrelevant because of the hourslong half lives, low volume of distribution and extensive hepatic metabolism attributable to the 17a-methyl attachment. First pass is a “mere blip” for these drugs.

 

[AlmightyAlpha]

First pass metabolism is practically irrelevant because of the hourslong half lives, low volume of distribution and extensive hepatic metabolism attributable to the 17a-methyl attachment. First pass is a “mere blip” for these drugs.

That's why injectable is easier