MESO-Rx Exclusive 1-Testosterone (DHB): Effects, Risks, and Hepatotoxicity

[MESO-Rx Administrator]

Learn about DHB in @Type-IIx's continuing series exploring the unique characteristics of various anabolic-androgenic steroids. Specifically, 1-Testosterone (DHB) is a non-aromatizable, hepatotoxic anabolic steroid with unique metabolism to DHT. Known for severe post-injection pain and other risks, it may also act as a weak 17β-HSD1 inhibitor, influencing estrogen balance. Learn its effects and risks.

Dihydroboldenone Insights: Unique Characteristics of Anabolic-Androgenic Steroids – Part 9

Explore the unique benefits of DHB bodybuilding special uses for enhancing muscle growth and performance in athletes.

thinksteroids.com

 

[Type-IIx]

BOOM, article dropped! Learn about the weirdness of dihydroboldenone (DHB; 1-Testo) and why it increases DHT, and what that means for effects/side effects

 

[Fizzik]

The increase E1(estrone) is interesting. We know a metabolite of Boldenone is 5AR to 1-Testosterone. I wonder if this same reduction is what DHB and Boldenone have in common for increasing E1 and in some individuals lowering E2.

 

[Type-IIx]

The increase E1(estrone) is interesting. We know a metabolite of Boldenone is 5AR to 1-Testosterone. I wonder if this same reduction is what DHB and Boldenone have in common for increasing E1 and in some individuals lowering E2.

It’s not, actually!

Boldenone (EQ) doesn’t 5α-reduce to DHB in vivo in man. [1]. It's part of the reason why I'm very careful to designate it by its name from the nomenclature, 1-Testosterone (1-Test; 1-Testo).

Boldenone singularly produces 5α-androst-1-ene-3,17-dione in vivo in man, in only minuscule amounts since it is so resistant to 5α-reductase. [1].

I actually wrote about why boldenone (EQ) has these effects you're referring to here:

Primobolan / Equipoise Crashed my E2 – Help!

Understand the complex interaction of Primobolan and Equipoise with estrogen levels, symptoms of low estrogens, and practical decision-making strategies for managing these effects in AAS users.

thinksteroids.com

---
References
[1] Goto, T., Tohkin, M., & Yamazoe, Y. (2019). Solving the interactions of steroidal ligands with CYP3A4 using a grid-base template system. Drug Metabolism and Pharmacokinetics. doi:10.1016/j.dmpk.2019.05.003

 

[Type-IIx]

It’s not, actually!

Boldenone (EQ) doesn’t 5α-reduce to DHB in vivo in man. [1]. It's part of the reason why I'm very careful to designate it by its name from the nomenclature, 1-Testosterone (1-Test; 1-Testo).

Boldenone singularly produces 5α-androst-1-ene-3,17-dione in vivo in man, in only minuscule amounts since it is so resistant to 5α-reductase. [1].

I actually wrote about why boldenone (EQ) has these effects you're referring to here:

Primobolan / Equipoise Crashed my E2 – Help!

Understand the complex interaction of Primobolan and Equipoise with estrogen levels, symptoms of low estrogens, and practical decision-making strategies for managing these effects in AAS users.

thinksteroids.com

---
References
[1] Goto, T., Tohkin, M., & Yamazoe, Y. (2019). Solving the interactions of steroidal ligands with CYP3A4 using a grid-base template system. Drug Metabolism and Pharmacokinetics. doi:10.1016/j.dmpk.2019.05.003

I apologize for a typo in the footnote, I don't recall that as the correct study but rather this one:

Schänzer W, Donike M. Metabolism of boldenone in man: gas chromatographic/mass spectrometric identification of urinary excreted metabolites and determination of excretion rates. Biol Mass Spectrom. 1992 Jan;21(1):3-16. doi: 10.1002/bms.1200210104

Though it's probably referenced by both.

 

[Sampei]

BOOM, article dropped! Learn about the weirdness of dihydroboldenone (DHB; 1-Testo) and why it increases DHT, and what that means for effects/side effects

It's not needed guaiacol to keep DHB in solution, you can brew 120mg/ml (standard brewing dosage as above that it's has unbearable pip) in castor oil without any other solvents except BB/BA.


Too bad it has all those other not nice side effect as explained: systemic inflammation, possible cancer and hepatoxicity on the liver.

I guess I'll just throw away or never use the 100gr of DHB raw I have in my stash

 

[Type-IIx]

It's not needed guaiacol to keep DHB in solution, you can brew 120mg/ml (standard brewing dosage as above that it's has unbearable pip) in castor oil without any other solvents except BB/BA.


Too bad it has all those other not nice side effect as explained: systemic inflammation, possible cancer and hepatoxicity on the liver.

I guess I'll just throw away or never use the 100gr of DHB raw I have in my stash

Cool, I'm not a brewing wizard, and this is the first I've heard of this... you've injected it personally and it's not painful to the point of training interruption?

 

[Type-IIx]

BTW, I am pretty keen on publishing someone's raw, unvarnished brew notes on the Ampouletude Bookstore if they have a reputation for good product. I think that could sell pretty well and would be valuable.

 

[Fizzik]

It’s not, actually!

Boldenone (EQ) doesn’t 5α-reduce to DHB in vivo in man. [1]. It's part of the reason why I'm very careful to designate it by its name from the nomenclature, 1-Testosterone (1-Test; 1-Testo).

Boldenone singularly produces 5α-androst-1-ene-3,17-dione in vivo in man, in only minuscule amounts since it is so resistant to 5α-reductase. [1].

I actually wrote about why boldenone (EQ) has these effects you're referring to here:

Primobolan / Equipoise Crashed my E2 – Help!

Understand the complex interaction of Primobolan and Equipoise with estrogen levels, symptoms of low estrogens, and practical decision-making strategies for managing these effects in AAS users.

thinksteroids.com

---
References
[1] Goto, T., Tohkin, M., & Yamazoe, Y. (2019). Solving the interactions of steroidal ligands with CYP3A4 using a grid-base template system. Drug Metabolism and Pharmacokinetics. doi:10.1016/j.dmpk.2019.05.003

Interesting, lots above my head but I get the gist. I had a bad experience using primo any dosage seems to affect my sleep and affect my joints. Although everyone touts its low side effect profile, was not the case for me. I aromatize heavily, so I had hoped primo was the smoking gun. I have yet to try EQ, but it’s next on my list. Hoping it helps with my aromatizing effects from test but not to the same affect as primo.

 

[Type-IIx]

BTW, I am pretty keen on publishing someone's raw, unvarnished brew notes on the Ampouletude Bookstore if they have a reputation for good product. I think that could sell pretty well and would be valuable.

Pseudonymously, of course. And I'd have to run it by legal counsel

 

[Type-IIx]

Interesting, lots above my head but I get the gist. I had a bad experience using primo any dosage seems to affect my sleep and affect my joints. Although everyone touts its low side effect profile, was not the case for me. I aromatize heavily, so I had hoped primo was the smoking gun. I have yet to try EQ, but it’s next on my list. Hoping it helps with my aromatizing effects from test.

Bro... I am with you 100% on Primo's purported mild effects vs. reality. I see a lot of bloodwork over the years coaching and managing it for clients' protocols, and it's definitely a widespread delusion. Primo's the only drug besides Tren I see give nightsweats at like 200 mg weekly for some users.

Not "beware," but do be aware of the fact that if you aromatize heavily and have a particular genetic profile (e.g., 17β-HSD, binding hormone, and Aromatase expression-dependently), a minor take-away point from the EQ & Primo crashed my E2 article above is that for most people, depending on genetic factors, EQ straight up aromatizes to E2 pretty potently at ~ 58% the rate of testosterone.

 

[Type-IIx]

It's not needed guaiacol to keep DHB in solution, you can brew 120mg/ml (standard brewing dosage as above that it's has unbearable pip) in castor oil without any other solvents except BB/BA.


Too bad it has all those other not nice side effect as explained: systemic inflammation, possible cancer and hepatoxicity on the liver.

I guess I'll just throw away or never use the 100gr of DHB raw I have in my stash

I'm asking around about this to see whether anyone reports being able to train after brewing and using DHB like this. Maybe if your E2 is high, since estrogens reduce pain perception, you might be able to train is my first thought, and there's individuality to pain tolerance. But that's virtually certainly going to cause C-rp elevations and inflammation like a motherfucker, too.

 

[Fizzik]

Bro... I am with you 100% on Primo's purported mild effects vs. reality. I see a lot of bloodwork over the years coaching and managing it for clients' protocols, and it's definitely a widespread delusion. Primo's the only drug besides Tren I see give nightsweats at like 200 mg weekly for some users.

Not "beware," but do be aware of the fact that if you aromatize heavily and have a particular genetic profile (e.g., 17β-HSD, binding hormone, and Aromatase expression-dependently), a minor take-away point from the EQ & Primo crashed my E2 article above is that for most people, depending on genetic factors, EQ straight up aromatizes to E2 pretty potently at ~ 58% the rate of testosterone.

Yes I had the night sweats at 200mg. Couldn’t sleep was a nightmare lol.

Hmm, I may be one of those people with that gene, this has me thinking of people that got away with EQ/Deca solo cycles back in the day. Where those individuals were fine running no test.

Will have to experiment and if so could run low test, say 100mg and add on EQ/Mast/Deca. Little theory crafting for us unfortunate in the genetic department.

 

[Type-IIx]

Yes I had the night sweats at 200mg. Couldn’t sleep was a nightmare lol.

Hmm, I may be one of those people with that gene, this has me thinking of people that got away with EQ/Deca solo cycles back in the day. Where those individuals were fine running no test.

Will have to experiment and if so could run low test, say 100mg and add on EQ/Mast/Deca. Little theory crafting for us unfortunate in the genetic department.

Without being totally invasive, because your full DNA profile contains sensitive information, I would love to start seeing more sharing of particular genes/SNPs and the like that are relevant to AAS in bodybuilding. We could do a whole lot of not only explanation but prediction and if capable, really precise individualization of cycle design.

I do this on a limited basis (limited by the depth and scope of the literature that supports conclusions from such SNPs; and limited by the fact that I don't coach the whole world) for clients with the means and motivation to drop the funds for these sorts of testing, as they advance.

Some guys come in gung-ho with their full DNA profile and tons of knowledge, but their training status is novice - that makes no sense to apply yet - just as guys who are approaching international-elite in bodybuilding without the funds to get these tests makes no sense for such focused work, of course.

 

[Type-IIx]

Relevant genetic factors include those here: What is the Meaning of "Genetics" for Bodybuilding?

 

[Sampei]

Cool, I'm not a brewing wizard, and this is the first I've heard of this... you've injected it personally and it's not painful to the point of training interruption?

@narta he is the owner of the recipe 120mg/ml dhb castor oil PIPless

I still have to brew it myself, but not once a recipe given by him hasn't been PIPless if he said that it was.

I haven't been keen in trying it for now because I'm was worried of the systemic inflammation, I wonder if that is from the brewing or it's just the DHB that it's fucking you up no matter what even if you have no PIP from it.

When I have more time and I don't mind fucking up myself a little bit ill run it and do some blood work to see what is what.

 

[Type-IIx]

It's not needed guaiacol to keep DHB in solution, you can brew 120mg/ml (standard brewing dosage as above that it's has unbearable pip) in castor oil without any other solvents except BB/BA.


Too bad it has all those other not nice side effect as explained: systemic inflammation, possible cancer and hepatoxicity on the liver.

I guess I'll just throw away or never use the 100gr of DHB raw I have in my stash

It's been so long since I submitted this article that I thought I said something that is incorrect here, but I simply wrote that:

I wrote that:

1-Testosterone interestingly metabolizes primarily to dihydrotestosterone (5α-dihydrotestosterone; DHT) despite being non-5α-reducible, and is particularly hepatotoxic – unusual for an injectable AAS – both directly, with evidence of its increasing liver size in animal data, and indirectly, since industrial grade solvents like guaiacol, a hazardous chemical and likely carcinogen, are typically used by manufacturers and chemists to hold 1-testosterone in solution.


1-Testosterone’s particular intolerability and contentious anabolic effects – being regarded by one faction of loyalists as a “Tren lite,” versus another faction of detractors that regard it as basically Primo [of the same class of 1-enes] but with post-injection pain (PIP) and C-reactive protein (CRP) elevations, rank it among the less useful AAS category for bodybuilders.

Still, though, while nobody has ever attempted this brew, they're going to try it and report back for us.

 

[narta]

@narta he is the owner of the recipe 120mg/ml dhb castor oil PIPless

I still have to brew it myself, but not once a recipe given by him hasn't been PIPless if he said that it was.

I haven't been keen in trying it for now because I'm was worried of the systemic inflammation, I wonder if that is from the brewing or it's just the DHB that it's fucking you up no matter what even if you have no PIP from it.

When I have more time and I don't mind fucking up myself a little bit ill run it and do some blood work to see what is what.

I am the owner of dick squat, I just experiment with shit, although castor oil seems to mitigate the pip. Systemic inflammation registered through crp is the main concern with this compound though

 

[Type-IIx]

@narta he is the owner of the recipe 120mg/ml dhb castor oil PIPless

I still have to brew it myself, but not once a recipe given by him hasn't been PIPless if he said that it was.

I haven't been keen in trying it for now because I'm was worried of the systemic inflammation, I wonder if that is from the brewing or it's just the DHB that it's fucking you up no matter what even if you have no PIP from it.

When I have more time and I don't mind fucking up myself a little bit ill run it and do some blood work to see what is what.

Sorry I didn’t mean literally “nobody,” just that nobody in the brewing group who was available yesterday had made such a blend. Most admonished against it as too unlikely to hold or be usable long-term.

So to get anywhere you just gotta take a position. Mine then was that I think it’ll probably crash.

I offered for a guy to just brew it and let it sit in a well-lit place on a webcam for 10 days, and we can just watch it crystallize.

He came out hot saying for sure he’d brew it and run it, but then his regard for his own health probably did get the better of him…

Most guys seem to just avoid the compound, especially if they brew, it seems. It’s more a kind of exotic finished product.

For me, 1-testo stands out as really the one great thing associated with Dr. Bill Llewellyn. The Anabolics books suck something fierce, but he was the first to be credited with formulating a working lipophilic core to deliver oral 1-Test back during the Designer Steroid Era of the mid-2000, using the principles of Anabolicum Vister (quinbolone; oral EQ, an old pharma drug you’d take 200 mg daily).

Basically rather than 17a-alkylation it used a lipophilic core and had good flow and sufficient bioavailability through lymphatic absorption, bypassing the liver truly unlike sublingual 17AA drugs.

 

[Sampei]

I am the owner of dick squat, I just experiment with shit, although castor oil seems to mitigate the pip. Systemic inflammation registered through crp is the main concern with this compound though

But you can confirm first hand that it does hold no problem without using any extreme solvents like guaiacol, correct?