17‐alpha‐estradiol

[LoremIpsum9921]

I guess since we already use exogenous hormones to optimize our body for a given goal, why not have a look at some promising hormones for longevity.
From a longevity standpoint, 17-alpha-estradiol is maybe one of the most effective interventions for male mice to extend the lifespan.
It's one of the substances that showed in the ITP longevity benefits. Furthermore, it's not feminizing and thus there is little to no risk for gyno.
Various studies like this show promising effects


It would be interesting to see if we can compensate the side effects from lower 17-beta-estradiol by using the non feminizing 17-apha-estradiol variant. What I mean, we could keep 17b-estradiol on the lower end using primo or AI, reduce the risk for gyno as much as possible, but compensate the side effects of lower estradiol with the non-feminizing variant.
Perhaps that's not possible because some or all of the positive effects from 17-beta-estradiol (on cycle), are inseparable from the feminizing aspect. But I could not find anything on it. Even in this case, it's really promising for longevity and could be a nice ancillary for its health benefits.

Since I identify myself as a male mouse, I'm curious if anyone tried here 17-alpha-estradiol or has some thoughts on it?

Of course, sourcing is problematic. If a chinese vendor doesn't separate both stereoisomers correctly, we will transition to a woman in no time. Just to state it again, the 17-alpha variant is non-feminizing.

 

[IndividualMan]

shit, this sounds nice.
could be useful when accidentally nuking E2, or for hairloss. but other than that I am not too sure if this is what people are willing to risk (17-beta contamination)

 

[LoremIpsum9921]

shit, this sounds nice.
could be useful when accidentally nuking E2, or for hairloss. but other than that I am not too sure if this is what people are willing to risk (17-beta contamination)

17-beta contamination is probably the highest risk, but I think not really more dangerous compared to people here injecting chinese tren.
Also, testing would be of course also mandatory here, just like for all the other steroids.

Regarding hair loss topical 17-alpha-estradiol is already approved for hair loss in europe as Ell-Cranell Alpha. Based on the ingredients, you could safely drink this solution (0.25 mg / ml), but it would cost a bit per month to sustain this.

 

[Photon]

Looks pretty cheap, spectrum chem has it for 185 for 250mg, assuming one takes 1mg a week that's like 250weeks worth.

Main question is, does it turn up as e2 on labwork?

Edit: probably won't work, I think the half life is too short

 

[LoremIpsum9921]

Looks pretty cheap, spectrum chem has it for 185 for 250mg, assuming one takes 1mg a week that's like 250weeks worth.

Main question is, does it turn up as e2 on labwork?

I guess 1 mg is not enough to harvest the positive effects.
The dose used in the mice studies was 14.4 mg/kg/day. Which even converted to the human dose equivalent sounds far too high. On other forums like rapamycin.news people use 4-8 mg doses per week.

Not that relevant, but Bryan Johnson takes 8 mg per week.

I'm not sure if the test can differentiate between both stereoisomers.

 

[IndividualMan]

I guess 1 mg is not enough to harvest the positive effects.
The dose used in the mice studies was 14.4 mg/kg/day. Which even converted to the human dose equivalent sounds far too high. On other forums like rapamycin.news people use 4-8 mg doses per week.

Not that relevant, but Bryan Johnson takes 8 mg per week.

I'm not sure if the test can differentiate between both stereoisomers.

4-8 mgs is a hefty dose. you really gotta go with good testing/ have a LOOOOOT of trust in your vendor for that. or go with a standard chemical vendor

 

[LoremIpsum9921]

4-8 mgs is a hefty dose. you really gotta go with good testing/ have a LOOOOOT of trust in your vendor for that. or go with a standard chemical vendor

Definitely a hefty dose if they don't care about the isomer and just ship a 50/50 mixture or even worse, just 17-beta-estradiol. Testing should give clarity. But right now, I'm not aware of any source here on meso that offers 17-alpha-estradiol.

 

[tut]

I grabbed some raws for this last year from SSA before they went down. Janoshik can test it.. mine came back as 17a estradiol ~93% purity.

Did not seem to affect my sensitive or non-sensitive estradiol bloodwork; at least I did not see any deviation or numbers outside of what I would expect for myself at that point in time.

 

[tut]

Edit: probably won't work, I think the half life is too short

Brew in castor oil and then create a depot effect?

 

[Photon]

I grabbed some raws for this last year from SSA before they went down. Janoshik can test it.. mine came back as 17a estradiol ~93% purity.

Did not seem to affect my sensitive or non-sensitive estradiol bloodwork; at least I did not see any deviation or numbers outside of what I would expect for myself at that point in time.

What dose did you use?

 

[LoremIpsum9921]

I grabbed some raws for this last year from SSA before they went down. Janoshik can test it.. mine came back as 17a estradiol ~93% purity.

Did not seem to affect my sensitive or non-sensitive estradiol bloodwork; at least I did not see any deviation or numbers outside of what I would expect for myself at that point in time.

Awesome! What was your experience with it? I hope some other vendor here will also start selling the 17a estradiol.

Brew in castor oil and then create a depot effect?

I am not sure if castor oil and injections make much of a difference, if it's not an ester.
The longevity studies used daily oral dosing.

 

[tut]

What dose did you use?

Oral equivalent dosing of roughly 10 mg/day. And to reiterate at this dosing, I did not observe any abnormal deviations in my sensitive/non-sensitive e2 bloodwork.. I typically dosed around an 1hr prior to bloodwork.

 

[tut]

Awesome! What was your experience with it? I hope some other vendor here will also start selling the 17a estradiol.

Not much to report tbh.. the objective metrics (e2 blood work) I looked at did not change and subjectively I felt no different.

I did not experience any typical high E2 symptoms from it such as gyno/mood/libido issues. But that doesn't surprise me given 17α-E2 exhibits significantly lower estrogenic potency than 17b-E2.