1mg Arimidex too high?

[Delmann]

I just got back my bloodwork for my 2 month followup for TRT. Currently take 100mg of Test C weekly split into two doses (Tuesday/Friday) and 1500IU of HCG weekly split into three doses (M/W/F)

Estradiol: 71pg/mL (Reference below 39)
Total T: 673ng/dl (reference range 250-1100)
Testosterone, Free: 209.7pg/ml (35-155.0)
Hemoglobin 15.5 (13..2-17.1)
Hemocrit: 47.3 (38.5-50)
PSA, Total: 41

I'm wondering if I should just half my HCG dose instead and then rerun my E2 in 3-4 weeks to see if that brings me down or just split the Arimidex and take half a pill weekly instead of the full pill. I don't want to crash my E2

Bloods were drawn 3.5D after my last injection right before my Tuesday morning pin so at a trough.

Thanks

 

[Grey Spartan]

I would half the HCG, take the whole pill for 2 weeks then half a pill for the second 2 week then check again. This is what I did when my Estradiol was 51 and it was 25 after the 4 weeks. But, I was also taking 170mg of Test-C a week split into two doses (same HCG).

 

[Intrepid]

Are you trying to have a kid, or are you just concerned about slightly smaller testicles?

If you're going constantly be on TRT, and the above doesnt apply I don't really see the purpose of HCG. All you're doing is risking desensitization.

"Studies on hCG and Leydig cell desensitization have investigated how human chorionic gonadotropin (hCG) can cause Leydig cells to become unresponsive to gonadotropin stimulation:


Receptor downregulation
A single injection of hCG can cause a reduction in the number of hCG receptors on Leydig cells. This can make it less likely that the receptors will be activated.

Suppressed cAMP-mediated response
hCG can also increase the activity of PDE, which suppresses the cAMP-mediated response. This provides another way for Leydig cells to resist activation.

Defective coupling
Even when binding sites are present and adenylate cyclase is normal, hCG-induced desensitization can occur. This could be due to a defective coupling between the receptor sites and the catalytic subunit. "


and even if you did crash your estrogen, it would bounce back very quickly. I'd reduce the HCG a bit and that'll help stop the estrogen spikes

 

[Delmann]

Are you trying to have a kid, or are you just concerned about slightly smaller testicles?

If you're going constantly be on TRT, and the above doesnt apply I don't really see the purpose of HCG. All you're doing is risking desensitization.

"Studies on hCG and Leydig cell desensitization have investigated how human chorionic gonadotropin (hCG) can cause Leydig cells to become unresponsive to gonadotropin stimulation:


Receptor downregulation
A single injection of hCG can cause a reduction in the number of hCG receptors on Leydig cells. This can make it less likely that the receptors will be activated.

Suppressed cAMP-mediated response
hCG can also increase the activity of PDE, which suppresses the cAMP-mediated response. This provides another way for Leydig cells to resist activation.

Defective coupling
Even when binding sites are present and adenylate cyclase is normal, hCG-induced desensitization can occur. This could be due to a defective coupling between the receptor sites and the catalytic subunit. "


and even if you did crash your estrogen, it would bounce back very quickly. I'd reduce the HCG a bit and that'll help stop the estrogen spikes

Hey, thanks of the response,

Right now I am not trying to have a kid. I may want one in the future but not currently. I am just trying to stave off testicular atrophy. the 1500IU was what the doctor had told me to take, and I don't mind reducing it.

Plan to do TRT for the rest of my life and once I'm in better shape and been training for awhile do a blast but at my current physique I don't think it's smart so holding off until I'm at a better point in my fitness journey.

Just to make sure I understand correctly, are you just recommending I reduce the HCG dose and don't take the AI? Or stop the HCG completely (and still not take the AI)? Or do what Grey suggested and take the 1mg for 2 weeks and then half a dose, while also reducing my HCG by half.

Thanks again

 

[narta]

I may want one in the future but not currently.

If that is in your future, get off and become fertile, freeze some sperm and then hop back on. Longer the exposure to gear, longer the period you will need to have viable swimmers if any

 

[Intrepid]

Hey, thanks of the response,

Right now I am not trying to have a kid. I may want one in the future but not currently. I am just trying to stave off testicular atrophy. the 1500IU was what the doctor had told me to take, and I don't mind reducing it.

Plan to do TRT for the rest of my life and once I'm in better shape and been training for awhile do a blast but at my current physique I don't think it's smart so holding off until I'm at a better point in my fitness journey.

Just to make sure I understand correctly, are you just recommending I reduce the HCG dose and don't take the AI? Or stop the HCG completely (and still not take the AI)? Or do what Grey suggested and take the 1mg for 2 weeks and then half a dose, while also reducing my HCG by half.

Thanks again

for your purposes maybe keep hcg the same, then just increase the AI. you just need to get your estrogen down.

so either:
-reduce HCG and keep AI dose the same
-keep HCG the same, and increase AI dose

also look into HMG "Human Menopausal Gonadotropin" ; it's exactly what you're going to want if youre trying to conceive

 

[Delmann]

Awesome, thank you guys for the feedback, it gives me a lot to think about.

Appreciate the advise.

 

[Jabbathehutt]

Reduce body fat and inject ED.