Hi all - looking for some advice on how to approach my testosterone titration.
I've been on TRT for about 4 months now. Started off at 100mg per week of test C, increased to 125mg per week about 2 months ago, and then increased to 160mg per week about 1 month ago. IM injection MWFS.
Prior to increasing dosage to 160mg/week:
- Total T: 1176
- Free T (direct MS assay): 225
- Bioavailable T: 493
- E2: 54
- SHBG: 27
Dosing goal is to settle somewhere 300 - 500mg/week.
Not taking an AI. Not emotional and don't have sensitive nipples or anything like that.
About two weeks ago, I increase my dose from 160mg/week to 240mg/week. This seems to have brought about some sleep issues due to what I suspect is from my E2 creeping too high. I have been waking up throughout the night and having difficultly falling back asleep. Usually no issues falling asleep. Additionally, I noticed some slight issues with delayed orgasm/ejaculation.
Is this possibly because I increased my test dosage too quickly resulting in my E2 getting too high? I have 0.25mg capsules of anastrozole on hand but haven't taken them yet as I'm not confident it's the cause. Have more bloodwork scheduled in a couple weeks to get cortisol, prolactin, T, E2, other helpful markers.
Searched around the forum and it seems like there are two schools of thought: skip titration and front load or titrate up over extended periods (12 weeks) due to length of time it takes to reach serum concentrations in blood.
Thanks in advance.
I've been on TRT for about 4 months now. Started off at 100mg per week of test C, increased to 125mg per week about 2 months ago, and then increased to 160mg per week about 1 month ago. IM injection MWFS.
Prior to increasing dosage to 160mg/week:
- Total T: 1176
- Free T (direct MS assay): 225
- Bioavailable T: 493
- E2: 54
- SHBG: 27
Dosing goal is to settle somewhere 300 - 500mg/week.
Not taking an AI. Not emotional and don't have sensitive nipples or anything like that.
About two weeks ago, I increase my dose from 160mg/week to 240mg/week. This seems to have brought about some sleep issues due to what I suspect is from my E2 creeping too high. I have been waking up throughout the night and having difficultly falling back asleep. Usually no issues falling asleep. Additionally, I noticed some slight issues with delayed orgasm/ejaculation.
Is this possibly because I increased my test dosage too quickly resulting in my E2 getting too high? I have 0.25mg capsules of anastrozole on hand but haven't taken them yet as I'm not confident it's the cause. Have more bloodwork scheduled in a couple weeks to get cortisol, prolactin, T, E2, other helpful markers.
Searched around the forum and it seems like there are two schools of thought: skip titration and front load or titrate up over extended periods (12 weeks) due to length of time it takes to reach serum concentrations in blood.
Thanks in advance.
