AI or SERM-only Protocol for TRT?

[Romulus]

I have been reading about the use of SERMs in low doses to raise test levels in hypogonadal men, and I have also stumbled across a couple of threads on using AI's for that purpose. I was personally about to begin a trial period on clomid before exploring full-out test replacement (I am at the bottom of the "normal" range). I would like to get feedback on these strategies (SERMs or AI's) for unsurpressive, moderate T increases. What is the latest, and who advocates what?

 

[zkt]

I have been reading about the use of SERMs in low doses to raise test levels in hypogonadal men, and I have also stumbled across a couple of threads on using AI's for that purpose. I was personally about to begin a trial period on clomid before exploring full-out test replacement (I am at the bottom of the "normal" range). I would like to get feedback on these strategies (SERMs or AI's) for unsurpressive, moderate T increases. What is the latest, and who advocates what?

Not sure about the latest or who advocates what but hormone stimulation has worked for some, or so they have said. Ive never gone for full T replcement this way but often some clomid with THC gives a noticable bump and a little variety. Not to mention giving the boys something productive to do.
Keep us posted on your results.

 

[Romulus]

Not sure about the latest or who advocates what but hormone stimulation has worked for some, or so they have said. Ive never gone for full T replcement this way but often some clomid with THC gives a noticable bump and a little variety. Not to mention giving the boys something productive to do.
Keep us posted on your results.

I'm pretty close to starting a clomid trial, and I will update on subjective and quants when I do more bloodwork. The other will, sadly, have to wait awhile--unless I move to Colorado or at least a semi-enlightened medical M state.

 

[zkt]

LMAO. I meant hcg.
But a nice sativa often perks things up too. LOL

 

[Romulus]

LMAO. I meant hcg.
But a nice sativa often perks things up too. LOL

Sounds like the good old days.....

 

[lifterjaydawg]

If this was the route I chose to try I would go with clomid as my first option.

 

[Romulus]

If this was the route I chose to try I would go with clomid as my first option.

Yeah, that's my inclination. There seems to be a lot more info and research on clomid, but I have seen some people whose opinions I greatly esteem mention AI's for the same purpose. I feel like I have enough info to try the clomid route though, so, yeah, that will be my first option.

 

[toolman]

Yeah, that's my inclination. There seems to be a lot more info and research on clomid, but I have seen some people whose opinions I greatly esteem mention AI's for the same purpose. I feel like I have enough info to try the clomid route though, so, yeah, that will be my first option.

.25 mgs eod clomid got all my labs where they should be. It just killed my libido so it wasnt an option long term

 

[Romulus]

.25 mgs eod clomid got all my labs where they should be. It just killed my libido so it wasnt an option long term

You are not the first to report that. I'm just trying to understand the physiology behind it. What do you think is the cause for that? Test levels...good. E2....good. What gives, I wonder?

 

[zkt]

99% of libido lies in the neurochemistry- think the answer is buried in the neurotransmitters somewhere.

 

[imrj]

99% of libido lies in the neurochemistry- think the answer is buried in the neurotransmitters somewhere.

absolutely does....i am totally convinced of this now based on my experience...

 

[Jimmyinkedup]

I think the answer ies in the agonist /antagonist estrogenic effects of the drug itself but I do not know. However while often people do seem to be able to achieve clinically acceptable numbers with clomid - it seems for whatever reason often the desired quality of life issues are still lacking (like libido)

 

[Romulus]

I ran across this study, and I hope some of you learned and experienced guys will take a look (I am not trained as a scientist, so I can't call myself qualified to evaluate the particular merits of any given study). It is unique among the ones I have seen in that it measures not only total but free test, as well as SHBG. Finally, it has a subjective, qualitative question-answer component, with libido included. While I have read many posts in forums about depressed libido, these test subjects seemed to answer the exact opposite. Check it out:

Study shows clomiphene is suitable for hormone therapy