What are the benefits besides the appetite suppression? I know there can be some improvements in blood glucose but I’m not sure about a whole lot else besides a possibility of reducing inflammation
An improvement of insulin sensitivity by direct action on neurons. Since GLP crosses the blood brain barrier it improves brain function, for instance, and may be part if the mechanism of action for the widespread observation of lessening of addictive behavior.
This very likely acts to protect against neurodegeneration of all types, protecting vision for instance, as demonstrated by some of the initial research into this.
Systemic inflammation is reduced, by acting on the vagus nerve, which acts like a probe that "senses" the presence of endotoxins, ie bacterial cell wall fragments, and taking this as a sign of infection in the body, triggers a chain of events in the brain that raises systemic levels of inflammation as a defensive reponse, This response seems to become dysfunctionally over sensitive with age, and can also be "tricked" by endotoxin from sources other than bacterial infection.
Elevated levels of systemic inflammation is a cause of damage to many organs, contributing to, often without symptoms, damage like arthritis, diabetes.
It very likely reduces damage to the endothelial layer of blood vessels, which are rich in GLP receptors. This could help reduce the rate at which plaque builds,
Now I want to be clear, while there's evidence of all these benefits to one degree or another, it's still early days, relatively speaking, though much of the experiments showing these potential benefits go back a decade or more ago, there's a long way to go.
However, given the risk / benefit (potential or otherwise), is so heavily skewed to the benefit side, and the general appetite of PED users to consume peptides and other compounds with far less evidence of safety or benefit, it seems rational to take the chance of what are, benefits that require long term exposure to exogenous supplementation of GLP,
After millions of years of patient experience with GLPs, going back decades, the risks seem pretty well understood, and barring a handful of negative effects more the impact of rapid weight loss or lowering of blood glucose, it's a very low risk, potentially high reward bet.
Far more than say, Testosterone to achieve a high, but still physiologic T level (which is also well worth the risk imo, but requires more caution and fraught with more potential harms),
