As long as it’s playing nicely with you. I switched to a low dose escitalopram and it’s doing what I need it to.
MESO-Rx
Anabolic Steroids
Anyone have experience with anti depressants/anxiety meds
- Thread starter Cookie Monster
- Start date
I’m 45 and just used my first antidepressant and it is Bupropion also. I was told it takes a few weeks to build up to noticeable levels. Did you really notice it overnight?
When I first used wellbutrin, it was 150mg SR, the first 2 weeks felt like I was on some low grade cocaine. I few years later, I got back on wellbutrin and did the XL and I didn't get that effect.
trtbuilder
Member
I started taking Lexapro for anxiety. A few weeks in. Seems to help my racing thoughts and the intensity of the anxiety so far. Will see how it goes.
bossetti
Member
I just work hard to try to have an amazing life no magic pill needed
bananafeet
Member
I'm on an SSRI and they are far from majick.
However they offset the negative effects of long term steroid abuse which lowers seratonin and BDNF.
The chemical imbalance theory is false, there is a new theory which explains why SSRI drugs even tho they act immediately take weeks to reduce anxiety/depression. That's the neurotrophic theory of depression. Basically chronic stress downregulates seratonin and therefore BDNF. On an SSRI it takes 5-6 months to get the full effect.
trtbuilder
Member
That's cool, but that's not how brains work. You're on a forum full of people in peak physical condition so it's not like we're a bunch of lazy fat slops. Show a little respect for other people.
xrayphoton13
Member
I have no reason to take them but after hearing Leo Longevity talk about how he uses fluvoxamine because it interacts with the sigma 1 receptor and it's good to have a little more serotonin and neuroplasticity, I started trialing 50mg fluvoxamine before bed just for the hell of it. It's probably been around 2 months. So far only thing I've noticed is a laugh and giggle more and it feels good to giggle. Hard to explain. Not sure if I'll continue it or not but it's been interesting for sure. Can't say I've noticed any cognitive improvements
mikeh1998
Member
I genuinely did. I sat down and watched TV after vacuuming my house. It was like my brain’s pleasure pathway got reconnected.
I used XL 150.
Negative side effect was that I started getting auditory hallucinations. Not hearing actual voices but it would sound like someone is having a conversation in another room when I was trying to sleep. I got used to it after a month though.
bananafeet
Member
Fantastic recommendation. I'm looking into this one.
Corsair
New Member
I haven't read any replies but just your post. I'm sorry to hear that man, you're still so young, I've had my episodes of depression/anxiety when i was young but also had brilliant vibrant wonderful life experiences at the same time. They sort of even each other out, looking back. I did start anti-depressants at a young age with wellbutrin, but quickly quit cause it made me moody and depressed (i was like 12-14 at the time). Tried again at 18 after i had a bad psychedelic experience, and zoloft helped me tremendously regain my sanity. I tried many anti-depressants throughout my late teens and early twenties. I can say with absolute certainty, wellbutrin increases anxiety moreso than any other anti-depressant I've ever tried. it's a double-edged sword, it's a great mood balancer and anti-depressant, but it increases my anxiety a good bit. Zoloft took a while to work, but it both made me feel back to normal happy and eliminated my panic attacks/anxiety. But after some time it sort of made my feel numb to emotions. Wellbutrin is a SNRI i think, it effects norepinephrine and some other stimulating brain receptors like nicotine related ones. Whereas SSRI's mostly hit serotonin receptors.
Everyone's different and reacts differently to different meds. Your still young, your brain is still developing, try everything else first besides medicine. Make meds a last call. They're over prescribed, sometimes just working yourself makes the biggest difference.
mikeh1998
Member
this is nonsense. start fixing your brain as soon as you can.
what’s next, don’t take accutane in your teens because your face is still developing, instead become a 25 year old with irreversible acne scars all over your face?
if you guys wanna waste time reading philosophy books and meditating and listening to subliminals go ahead. the advice is nonsense and not based in anything other than “medicine bad”.
i know so many people in their 20s and 30s that have crippling depression and anxiety but they’re so sheepishly obsessed with “inner work” that they’ve been failing at for literal decades…
get some balls and swallow a pill and get on with your life dude damn.
Corsair
New Member
im not sure if your pro medicine or anti meds. I'm honestly neither. i was on multiple anti-depressants throughout my late teens/early twenties, on and off. I'm not one to discourage the use if it's applicable. I only hesitate because i think anti-depressants are overprescribed. Im not against them, I just think other options should be pursued before meds. What's your complaint?
mikeh1998
Member
what the hell are you asking me
bananafeet
Member
The problem with the anti antidepressants camp is they provide no practical solutions to the billions of people who take these medications every year.
Usually these people have never actually experienced clinical anxiety or depression and think it's just a "feeling".
Like all drugs there are side effects and a risk/reward profile. Regarding the efficacy it isn't so much that antidepressants don't work better than placebo, but that placebo is effective for low to moderate depression.
After taking these meds I see them as no different to steroids or peptides. You're just messing with regulatory systems in the body.
A lot of people self medicate for anxiety and depression with amphetamines, LSD, mushrooms, ketamine, alcohol, cigarettes, food, pain killers etc all these drugs effect neurotransmitters... Whether that's GABA or seratonin or glutamate or dopamine or noradrenaline.....
The issue with SSRIs and SNRIs is that they create a dependency and have to be titrated carefully. The longer you are on them the longer it takes to get off them.
Just my 2 cents.
Usually these people have never actually experienced clinical anxiety or depression and think it's just a "feeling".
Like all drugs there are side effects and a risk/reward profile. Regarding the efficacy it isn't so much that antidepressants don't work better than placebo, but that placebo is effective for low to moderate depression.
After taking these meds I see them as no different to steroids or peptides. You're just messing with regulatory systems in the body.
A lot of people self medicate for anxiety and depression with amphetamines, LSD, mushrooms, ketamine, alcohol, cigarettes, food, pain killers etc all these drugs effect neurotransmitters... Whether that's GABA or seratonin or glutamate or dopamine or noradrenaline.....
The issue with SSRIs and SNRIs is that they create a dependency and have to be titrated carefully. The longer you are on them the longer it takes to get off them.
Just my 2 cents.
Adi18
New Member
It's true though they're overprescribed. A dr will get paid by the drug company to put their patient on a particular anti depressent by a drug company and a bonus for how many. Im on them and dont think I could go off because if you miss a few doses you start getting these brain zaps. Theres no doubt some people need them but the commercials and advertisements market them as a miracle pill, where they should be the last resort. It's not like they're providing tests or scans to measure serotonin. It's just like youre feeling down? Here try these its a free sample. Also all the symptoms of depression are the same as low Testosterone. So they have their place but should be.the last resort
bananafeet
Member
This is an American centric view. I've not seen a single advertisement for Sertraline in my life. I'd never even heard of SSRIs until two months ago.
Yet somehow it's in the top 10 most prescribed medicines in my country (Australia).
These medicines are almost free. They are off patent. I literally bought a years supply from India for $30. Ain't no pharma company making money off these drugs. In fact SSRIs have been abandoned like steroids due to the saturation in the market and the lack of better alternatives. Every time they make a new drug they are afraid of comparing it to existing SSRIs because they are so cheap and effective.
For example the PBS refused to find vortioxetine a new Wizz bang drug for Aussies because it wasn't good enough to justify the ridiculous price:
"The PBAC rejected the submission on the basis that the clinical place of vortioxetine
relative to SSRIs and SNRIs was unclear and that the claim of non-inferiority of
vortioxetine compared to duloxetine was not adequately supported. Therefore, the
cost-minimisation analysis against desvenlafaxine alone and the pre-PBAC
response’s proposal to list vortioxetine on a cost-minimisation basis against a
'''''''''''''''''''' SNRI class, were not accepted. In its consideration of the relevant
comparator, the PBAC was of the view that there was insufficient reason to exclude
SSRIs from an economic comparison which consequently did not support a cost-
minimisation analysis of vortioxetine against a ''''''''''''''''''''' SNRI class of drugs."
Source: https://m.pbs.gov.au/industry/listi...ings/psd/2014-07/vortioxetine-psd-07-2014.pdf
If you're having trouble coming off you need to look up the parabolic tapering method by Horowitz. He has videos on YouTube.
Antidepressant withdrawal from both sides of the desk - Dr Mark Horowitz, MBBS PhD
Update: The antidepressant tapering clinic I co-founded in the United States (Outro Health) is actively accepting patients into its Taper Management program
markhorowitz.org
Best of luck.
a05
New Member
Have tried zoloft and buspirone. Zoloft didn't really do much for me personally, but buspirone helps noticeably. Selank I've heard is decent for anxiolytic stuff so you could try that, but ssri wise, there are a lot of options, and each of them affects everyone differently, so if you go that route, try them until you find one that works I guess.
YiL
New Member
Ive been taking Zoloft for a year because of a complex ptsd. It has some positive sides but also some negative sides….. I stopped because I wasn’t happy for what it did for me. All the bloodwork came out good, except for testosterone levels (this was last month)….
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