AOD 9604 cloudy, crystals on vial

[Titsfordays]

I’ve been trying to research why this happened and the answers are all over the place. I reconstituted a 2mg bottle of AOD with 2ml of bac water. The result is slightly cloudy with crystals not dissolving and sticking to the vial. I’ve tried leaving it for a day, gently rolling it, turning it upside down multiple times (gently), etc. to no avail. Some say this is normal, some say get rid of it, some say it’s the bac water. I am using the same batch with the same bac water and this is my 4th vial. All other vials were clear. The question is, should it be tossed or would you still use?

 

[TessaM]

This has happened with a lot of the AOD out there right now -- testing by Jano has been showing that it's not soluble and has very little detectable in it. YMMV tho. What did you end up doing?

 

[Titsfordays]

This has happened with a lot of the AOD out there right now -- testing by Jano has been showing that it's not soluble and has very little detectable in it. YMMV tho. What did you end up doing?

Still used it, no issue. I did a little more research beforehand on other forums first and found some good information. Mine never gelled, I chalked it up to the new 0.8% bac water I was using, as the previous ones I had reconstituted from the same batch with 0.9% never had this problem. Going to test my theory this week, using a new bottle of .09% bac water when I reconstitute. The AOD I am using was tested and is real, so we will see what happens.

 

[ErlichBachman]

I am having the same issue using 0.9% Hospira, using 2ml. I seem to notice this toward the end, but I will pay more attention next time. I filled the vial again and whatever has congealed on the sides of the vial will not dissolve; it's like glue.

I've seen some info that real AOD is extremely hydrophobic, and perhaps would benefit from a more acidic solvent (not sure what that is, I've seen acetic acid mentioned).

EDIT: I refilled and old vial that had gelled on the sides, and placed it in hot water for a minute, no real effect, then shook it vigorously and it seems like that helped dissolve the gel from the sides, but who knows what that is doing to the peptide. During the process, the solution foamed up.

I may try a once-weekly injection to see if I can dissolve the AOD initially, and not allow it to separate itself onto the sides of the vial, but I'm not particularly hopeful. I think AOD is going to be out for me in the future until someone smarter figures out a way to dilute it, as it seems a lot is separating from the water.

 

[ErlichBachman]

Not sure what the quality of this source is, but some info about cloudy AOD being legit: Real frag is always cloudy. Here is why. | World Of Peptides

(I am using AOD and Frag interchangeably)

 

[Titsfordays]

Not sure what the quality of this source is, but some info about cloudy AOD being legit: Real frag is always cloudy. Here is why. | World Of Peptides

(I am using AOD and Frag interchangeably)

If you go over to Jano Lab Testing Thread, he has a YouTube showing trizepatide being shaken and manhandled then tested after. It worked exactly the same as it did not being shaken. It’s a myth that they need to be fragilely handled. With that said, still not sure if that applies to all peptides or specific types. I did read that legit AOD does cloud so that does line up with that article, thanks for sharing. Like you, I think after this run with it, I’ll be done with AOD. My next one I have lined up is MOTS-C.

 

[ErlichBachman]

If you go over to Jano Lab Testing Thread, he has a YouTube showing trizepatide being shaken and manhandled then tested after. It worked exactly the same as it did not being shaken. It’s a myth that they need to be fragilely handled. With that said, still not sure if that applies to all peptides or specific types. I did read that legit AOD does cloud so that does line up with that article, thanks for sharing. Like you, I think after this run with it, I’ll be done with AOD. My next one I have lined up is MOTS-C.

Yeah, shaking itself didn't work, but the hot water/shaking combo did, and if this is enough to dilute the gel, might also be enough to alter the peptide. Plus, I'm not injecting hot water, and once it cooled, it separated again.

I will also be testing MOTS-C, been a much longer delay this go-round with my order, so still waiting on that.

I just ordered a diluent with acetic acid 0.6% and will report back if that works.

 

[TessaM]

I think two different issues -- clouding is ok, but there was a batch recently that became... gelled when reconstituted. Sounds like that's yours too. Impossible to extract and wouldn't dissolve. Jano couldn't get much from testing it. A bunch of vendors like QSC stopped selling it and a test across 5 is currently underway. Will likewise share results here.

Sounds like this stuff Nsblue6 got was the real deal though. Just beware there's probably some of the dud batch out there still.

 

[ErlichBachman]

Mine's from their last batch with the freshest/good Jano testing, received about 1 mo ago.

 

[Titsfordays]

Mine's from their last batch with the freshest/good Jano testing, received about 1 mo ago.

Mine was last batch too. Definitely let me know if that works, I still have a bunch to go through. I’m in my second month and you need to use it for 3 to see any kind of results, although I do believe it’s already making a difference for me.

 

[Titsfordays]

I think two different issues -- clouding is ok, but there was a batch recently that became... gelled when reconstituted. Sounds like that's yours too. Impossible to extract and wouldn't dissolve. Jano couldn't get much from testing it. A bunch of vendors like QSC stopped selling it and a test across 5 is currently underway. Will likewise share results here.

Sounds like this stuff Nsblue6 got was the real deal though. Just beware there's probably some of the dud batch out there still.

It’s not like a gel, it’s more sticky to the sides of the vial. Can still pull it from the vial without issue. I can’t remember the purity but I want to say it was 98 or 99% pure. I never buy anything that hasn’t been tested. I just don’t think I will use it again after this. Too many other avenues to try these days.

 

[Titsfordays]

Mine's from their last batch with the freshest/good Jano testing, received about 1 mo ago.

https://www.proimmune.com/wp-content/uploads/2021/08/ST55.pdf#page10

This is very informative. Thought I would share.

 

[ErlichBachman]

Just reporting back: I reconstituted 2mg vial of QSC AOD with 2ml 0.6% acetic acid from alphlabsupply (Amazon/ebay) 48 hours ago, and no crashing/gelling so far. I am not really certain how long it took last time before it started to solidify on the vial, but a vial only lasts me 6 days.

 

[Titsfordays]

Just reporting back: I reconstituted 2mg vial of QSC AOD with 2ml 0.6% acetic acid from alphlabsupply (Amazon/ebay) 48 hours ago, and no crashing/gelling so far. I am not really certain how long it took last time before it started to solidify on the vial, but a vial only lasts me 6 days.

Same 6 days per bottle. I reconstituted with .09% bac water and it’s not sticky now. I bought some of the acetic acid as well from same place you mentioned just in case. Thanks for letting me know it worked, appreciate it.