Aromasin/Exemestane in MCT or other oils?

[goonr]

This sounds interesting. Anyone else tried it? I don't want to use ethanol or dmso and mct sounds also good because of bioavailability.

Aromasin was soluble at 10mg/mL into MCT oil without much issue for me on a hotplate. Tastes pretty neutral and easy to dose with a 3mL slip tip syringe.

Some sources also indicate solubility in ethanol up to 15mg/mL or DMSO at 54mg/mL.

 

[Exhortae]

Aromasin yes, exemestane no

 

[Deleted member 127229]

Aromasin yes, exemestane no

Aromasin is the brand name for exemestane. They are the same thing

 

[gettinginshape]

This sounds interesting. Anyone else tried it? I don't want to use ethanol or dmso and mct sounds also good because of bioavailability.

This NIH article has some good info with solubility of exemestane into various oils in Table II:

Oral Bioavailability Enhancement of Exemestane from Self-Microemulsifying Drug Delivery System (SMEDDS) - PMC

Limited aqueous solubility of exemestane leads to high variability in absorption after oral administration. To improve the solubility and bioavailability of exemestane, the self-microemulsifying drug delivery system (SMEDDS) was developed. SMEDDS ...

www.ncbi.nlm.nih.gov

Magnetic stirring hotplate was helpful here, everything was well dissolved around 95-100c (Melting point of exemestane is ~190c, so I wasn't worried there).

 

[goonr]

Anyone tried doing more than 10 mg per ml in MCT? Like 15 or 20?

 

[goonr]

Why would you use MCT when you can use Humco? Tastes so much better and it’s cheaper and Humco is made to be an oral suspension vehicle. I do Exemestane 20 mg/ml in Humco.

Thought about it, but i would prefer a solution, i'm afraid i'm too lazy and forgetful for suspensions lol. Also i think for exemestane oil would be actually better for absorption.

Also apparently we don't have oral suspension vehicles in Germany, i would need to import it from US and also pay custom fees.

 

[Deskoze38192]

Thought about it, but i would prefer a solution, i'm afraid i'm too lazy and forgetful for suspensions lol. Also i think for exemestane oil would be actually better for absorption.

Also apparently we don't have oral suspension vehicles in Germany, i would need to import it from US and also pay custom fees.

View attachment 269736

Makes perfect sense

Yeah it’s only $15 for Humco here for 16oz.
I imagine that would be considerably more to import

 

[4Drago]

Seen some selling test and aromasin mix. Interesting. It was something like 200mg test 6mg aromasin. I guess it would work if this was exactly what you needed but I don't see the reasoning since everyone needs a different dose if at all.

 

[gettinginshape]

Anyone tried doing more than 10 mg per ml in MCT? Like 15 or 20?

Might be possible. If you want to guinea pig it I’d recommend using a larger flask not completely filled in case you run into the solubility limit and have to dilute. Some of this will also depend on the chain length of the MCT oil you’re using, I was using a cheap Amazon sourced MCT oil that I had left over from a keto run as opposed to the pure C8 I would brew with, since this was going to be an oral preparation anyhow.