foreveryoung
New Member
curious to hear from people that have used both at different times, also any theoretical discussion is welcome too
MESO-Rx
Anabolic Steroids
aromasin vs arimidex in trt
- Thread starter foreveryoung
- Start date
Like Doc said the other day. I dont think there is any formal use for AIs recognized in TRT. Perhaps he was referring to SERMS on that one but I think the same goes. I know you wont find any legit physicians writing it in the name of "TRT" so you should not expect any informed answers, but perhaps some speculation from some who have tried. And you know I like to speculate...[
)]
I just wanted to point out the obviouis differences as Adex is stated to lower circulating estrogen by about 75% via enzyme interaction.interference. Aromasone, I think also known as Exemistane, is technically a "suicide" inhibitor. Meaning it permanently renders Enzymes incapable of involving with hormones and for the life of the enzyme. It however, is said to have a 98% reduction rate in CIRCULATING estrogens.. However it should be noted that I have heard guys say that it is fairly controllable in real use and not so hard core as the implications may seem.
Keep in mind that these statistics are again based on SERUM COUNTS. Technically a TT must first involve its self with an estrogen to render an estrogen or E2, right? So, then the count in blood MUST be POST receptor involvement, at least for any that are generated throught the metabolic conversion process. But who is to say the body does not simply increase enzyme production to compensate for lack of estrogens at receptors? Of course if they are not there, then they are not getting made and released right?
So it must be working? I speculate it is to a large degree. However:
- I wonder the life of E2 in the body? At specific receptors? Once in the blood?
- I wonder if the body does not cling on to estrogens at receptors longer due to the lack of availability.
- I wonder if this does happen, would it encourage further conversion, mutation, or cannibalization of said estrogens at receptors or once in blood.
- Also AIs work by preventing production in the first place, they dont change estrogens. So what does this say about an estrogen's propensity to get "re-cycled/re-used at the next needy site? You have to wonder? And at what condition it in when it gets there.....
Bored again
)]I just wanted to point out the obviouis differences as Adex is stated to lower circulating estrogen by about 75% via enzyme interaction.interference. Aromasone, I think also known as Exemistane, is technically a "suicide" inhibitor. Meaning it permanently renders Enzymes incapable of involving with hormones and for the life of the enzyme. It however, is said to have a 98% reduction rate in CIRCULATING estrogens.. However it should be noted that I have heard guys say that it is fairly controllable in real use and not so hard core as the implications may seem.
Keep in mind that these statistics are again based on SERUM COUNTS. Technically a TT must first involve its self with an estrogen to render an estrogen or E2, right? So, then the count in blood MUST be POST receptor involvement, at least for any that are generated throught the metabolic conversion process. But who is to say the body does not simply increase enzyme production to compensate for lack of estrogens at receptors? Of course if they are not there, then they are not getting made and released right?
So it must be working? I speculate it is to a large degree. However:
- I wonder the life of E2 in the body? At specific receptors? Once in the blood?
- I wonder if the body does not cling on to estrogens at receptors longer due to the lack of availability.
- I wonder if this does happen, would it encourage further conversion, mutation, or cannibalization of said estrogens at receptors or once in blood.
- Also AIs work by preventing production in the first place, they dont change estrogens. So what does this say about an estrogen's propensity to get "re-cycled/re-used at the next needy site? You have to wonder? And at what condition it in when it gets there.....
Bored again
foreveryoung
New Member
are you sure about your comments about exemestane? it sounded to me like you were describing letrozole
Ehh? Errr!?!/// Not really sure.. And not gonna Conciliate ya either!!! LOL
I was just going from memory. But it seems like Letro and Adex are the two similar (75% reduction approx), and the Suicide inhibitor is the Exemistane. I could be wrong. So now we'll leave it up to others to research to sort out...LOL IF i was right, I have stood in your shoes before on this subject. If I was wrong then I stand in my same ones as always... LOL[)]
I was just going from memory. But it seems like Letro and Adex are the two similar (75% reduction approx), and the Suicide inhibitor is the Exemistane. I could be wrong. So now we'll leave it up to others to research to sort out...LOL IF i was right, I have stood in your shoes before on this subject. If I was wrong then I stand in my same ones as always... LOL[
)]
Good points. but what I am bringing to light now is the notion of E2 MODULATION with Aromasin/exemistane is different in PRACITICE for what these guys want. The idea with the Adex is pretty much load and go, Cause I think I recall you get the same response with lower doses pretty much. I COULD BE HIGH.......
But the point being that successful modulation with the 98% effective Aromasin is a point of TWEAKING the DOSE more so that loading up for a straight line 75% kill. While ADEX is still utiilized here in smaller amounts, I again suspect the same end resultes are achieved at lower doses MORE LIKELY than with Aromasin, as one would surely know it if taking the drug off label and it was reaching its effective action.....
Its really an analysis of the conundrum of PARTIAL dosing in contradiction to designed usages where as does PART of a DISABLER work MORESO IN FULL, OR does part of an ANNIALATOR work more surely in PART.... Kinds SOrta...
and yes, I am sure I left an H out somewhere....
But the point being that successful modulation with the 98% effective Aromasin is a point of TWEAKING the DOSE more so that loading up for a straight line 75% kill. While ADEX is still utiilized here in smaller amounts, I again suspect the same end resultes are achieved at lower doses MORE LIKELY than with Aromasin, as one would surely know it if taking the drug off label and it was reaching its effective action.....
Its really an analysis of the conundrum of PARTIAL dosing in contradiction to designed usages where as does PART of a DISABLER work MORESO IN FULL, OR does part of an ANNIALATOR work more surely in PART.... Kinds SOrta...
and yes, I am sure I left an H out somewhere....
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