I am going to keep this as my reference:
Testing for FreeT is unreliable and should not be done to avoid cost and confusion.
FreeT (and BioavailableT) should be calculated.
For why it is unreliable, read here:
http://jcem.endojournals.org/cgi/reprint/86/6/2903.pdf
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Dr Shippen uses nomogram.
His goal is to end up at FreeT=160 (100-250)
starting with ##'s for existing SHBG the nomogram figures required Total T
The link below is to a calculator that works the same as the chart, if one assumes Albumin=4.3
Usually that is close enough.
http://www.issam.ch/freetesto.htm
Second page of calculator gives details for mathematically /chemically inclined.
http://www.issam.ch/freetesuit.htm
It also lists the reference paper that is same as in the chart.
To facilitate units conversion, it is good to have this:
http://www.get-back-on-track.com/en/tools/umrechner.php
Looking at reference paper one notes that it was written in 1999, but actually it is based on science level of 1990 (specially about SHBG).
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This paper, written in 2006, discuses FreeT and Bio-Available-T in light of discovery that SHBG is build differently than thought of in 1990.
-------http://www.atypon-link.com/WDG/doi/pdf/10.1515/JLM.2006.050
Other than understanding the issue little better I am not able to make use of their recommended charts, they are of too small resolution. Wish there was a calculator similar to above posted but based on this new science, (hint, hint).
I take three values from this paper.
Table 2, 10 healthy young men , BAT level=5.5(nmol/L)
Table 4, 10 male control subjects, FT level=199(pmol/L)
and (most disturbing)
CalcV was reported to
overestimate BAT by a factor of 1.5–2.2
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I am assuming that one (who believes in the above)
would really set as a goal his BioAvailableT (and let the FreeT just be "close enough", all that while using TotalT as means to do calculations).
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When blood testing, only QuestDiagnostic have a one proper test for BAT and FreeT.
(Note that they do not do assay to arrive at the numbers, they calculate them,
it is spelled in that link).
One have to be careful however, because they actually push the other (wrong) test,
they just try to recoup money for the equipment they purchased.
http://www.questdiagnostics.com/hcp/topics/endo/testosterone.html?endo
ask for:
FreeT, Bioavailable, and Total Testosterone.
Those who cannot use Quest should just make sure that they secure TT, SHBG, Albumin from same blood draw, and use the calculator to get the FreeT and BioavailableT
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Ranges are here, (just do not use the middle two columns.
http://www.questdiagnostics.com/hcp/intguide/EndoMetab/Gen_Misc/Testosterone/Table 1.pdf
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Tests that they do:
http://www.questdiagnostics.com/hcp...age.jsp?fn=hcp_ig_testnames_Endocrinology.htm
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EndoManual 3rdEd 2004
http://www.questdiagnostics.com/hcp/intguide/EndoMetab/EndoManual_3rdEd_2004.pdf
Merc Manual
http://www.merck.com/mmpe/index.html
Link to chart (how to make it appear with in message?)
.