I run twice a week. One day is sprints, and the other is a long run. My sprints consiste of a 45 minute run. I start out by walking for five minutes, gradually getting my speed up. Then I sprint for 45 seconds, and walk for a minute. Every sprint, I slowly add a little speed. I do that for 41 minutes, then I end it by walking for four minutes.
The long distance run consists of three 15 minute gradual speed increases. I start out by walking for a minute, and then slowly increase the speed. I run at each speed for two minutes. Once I reach 15 minutes, I slow down to a walk and do the whole thing two more times.
Whenever I run on the treadmill, I make sure that I play with the incline. This helps reduce the force being strained right on the knee. I hope this helps.