TheProdigyCode
New Member
"Is there any real reason to go above 1% BA in an oil-based solution?
My thinking is that it might make sense for a long-term multi-dose vial (e.g., something you'll be using daily/every few days for months), because of multiple punctures over time + higher risk of accidental contamination or user error as the months go by.
From what I've read, BA is a worse co-solvent than BB, so bumping it up purely for solubility doesn't make much sense.
Also, in solutions with lots of punctures and extended use time, does >1% BA theoretically offer extra bacteriostatic protection? Or is the benefit minimal/flat after ~1–1.2% in an oil matrix?
Do any of you notice noticeable PIP (post-injection pain) at 1.5–2% BA levels? Am I missing something important here?
Thanks in advance
My thinking is that it might make sense for a long-term multi-dose vial (e.g., something you'll be using daily/every few days for months), because of multiple punctures over time + higher risk of accidental contamination or user error as the months go by.
From what I've read, BA is a worse co-solvent than BB, so bumping it up purely for solubility doesn't make much sense.
Also, in solutions with lots of punctures and extended use time, does >1% BA theoretically offer extra bacteriostatic protection? Or is the benefit minimal/flat after ~1–1.2% in an oil matrix?
Do any of you notice noticeable PIP (post-injection pain) at 1.5–2% BA levels? Am I missing something important here?
Thanks in advance
