Berberine/Metformin/Acarbose to reduce metabolic damage from binge eating?

[Luke391]

Been overweight and Binge eating most of my life. Lost weight bunch of times naturally but always gained it back. Started Tirzepatide in February and it's been really amazing, it fixed the binge eating for a while but after loosing a bunch of weight the hunger and binging came back. Upper the dose and same thing happened, lost some more and binging came back.
I'm on 10mg and will keep upping the dose, but the question is: could using one of the supplements/drugs I listed in the title help to restore insulin sensitivity and the metabolic damage and inflammation caused by the binge episodes? Not used chronically, but only after the instances of overeating using like 1000-1500mg of Berberine phytosome or 500mg Metformin or 200-400g Acarbose (just one, not all 3 togheter)

Does it make sense or no? Possible drawbacks? I know metformin and berberine are a mithocondrial toxin and that acarbose is linked to decreased strenght, but I was thinking the intermittent use and the addition of mithocondrial efficiency supplements and peptides (like carnitine, coQ10 and mots-c) could limit the negatives.

 

[eery]

do you have any symptoms? which ones?


i dont think you have any metabolic damage or excessive inflammation from the binge eating itself, what makes you think so?

if you have any underlying issues like metabolic syndrome, metformin and berberine could potentially help.

Good luck with your binging issues.

 

[Luke391]

do you have any symptoms? which ones?


i dont think you have any metabolic damage or excessive inflammation from the binge eating itself, what makes you think so?

if you have any underlying issues like metabolic syndrome, metformin and berberine could potentially help.

Good luck with your binging issues.

I definetly had poor insulin sensitivity before Tirzepatide, now I belive it's improved because after the binged I notice a bit less less water/fat retention than I used. But I still think it's far from optimal. Years and years of binging on shit food fucks with insulin sensitivity and many other processes, I fast regularly and that helps but still probably not enough.

I think I am chronically inflamed because I have had almost constant brainfog and "fibromyalgia" (if you wanna consider it a real thing) for a long time.
I'm taking NAC, vitamin C and a little Omega3 but I think I need something to counter in an acute way the negatives of the food benders.

also I think I have more visceral fat that I'd like, because even after fasting my stomach isn't super flat. I don't have a gut but it's not perfectly flat either

 

[Sampei]

So to make a visual example: you brought a nuclear bomb to the fight already but want to add a glock17 just because

Makes zero sense.
What you need to fix is your mind
You don't have any insulin issue, you are on 10mg of tirzepatide, what do you think some metformin is gonna do that tirzepatide is not already doing 10x better?

You have a mental issue, until you work on that you will continue to fail miserably.

You keep making threads about taking this and that when the only thing you need to learn is discipline and mental hygiene.

I say this not to make fun of you, I'm serious, talk to someone.

 

[DinoBB76]

Been overweight and Binge eating most of my life. Lost weight bunch of times naturally but always gained it back. Started Tirzepatide in February and it's been really amazing, it fixed the binge eating for a while but after loosing a bunch of weight the hunger and binging came back. Upper the dose and same thing happened, lost some more and binging came back.
I'm on 10mg and will keep upping the dose, but the question is: could using one of the supplements/drugs I listed in the title help to restore insulin sensitivity and the metabolic damage and inflammation caused by the binge episodes? Not used chronically, but only after the instances of overeating using like 1000-1500mg of Berberine phytosome or 500mg Metformin or 200-400g Acarbose (just one, not all 3 togheter)

Does it make sense or no? Possible drawbacks? I know metformin and berberine are a mithocondrial toxin and that acarbose is linked to decreased strenght, but I was thinking the intermittent use and the addition of mithocondrial efficiency supplements and peptides (like carnitine, coQ10 and mots-c) could limit the negatives.

In my opinion, the wrong thought is that I take GLP1, metformin + GDA, I eat shit from morning to night, I'll fix everyone

 

[Stealth500]

the GLP-1 inhibits hunger to where you only have room to eat whats essential..

Imagine the effect of eating only a tiny amount of shit food. As a sole source of nutrition.

 

[Luke391]

So to make a visual example: you brought a nuclear bomb to the fight already but want to add a glock17 just because

Makes zero sense.
What you need to fix is your mind
You don't have any insulin issue, you are on 10mg of tirzepatide, what do you think some metformin is gonna do that tirzepatide is not already doing 10x better?

You have a mental issue, until you work on that you will continue to fail miserably.

You keep making threads about taking this and that when the only thing you need to learn is discipline and mental hygiene.

I say this not to make fun of you, I'm serious, talk to someone.

Hey man, I get you're probably just trying to help, but thing is, I know my body and my mind. I know what works and what doesn't. It's not like I have an issue and just trowing out random drugs to take. I have tried to get this under controp for many years unsuccesfully. I have done therapy and tried many many mindfulness practices but it's always been completely ineffective. As I said, I had lost weight naturally before, but always gained it back because it was unsustainable.

I get I come off as some lazy guy who doesn't want to put effort but I really think that is not the case. I have always put massive efforts into fixing my problems normally but it has never worked. I have become very inclined towards drugs because I have seen how amazingly effective they are.
Using Tirzepatide showed me that my binge eating / appetite issues are not mental despite what I was told for years.
When I fist got on Tirz it all went away. I felt no urge to ever binge eat or overeat, it only came back after loosing a bunch of weight.
This pretty much showed me that it is not a phychiatric disorder but an issue of being under my body's "weight setpoint".

I am the leanest I've ever been in my life (and leaner than most people I see walking around in the gym).

I'm sorry for sounding like a broken record but I have become interested with drug use as I have seen how usefull they can be and I enjoy posting on this forum. I like the discussions with like minded people as I don't have many people in real life to talk to about this stuff.

 

[Luke391]

And this is what I currently look like. I am small as shit I know. I don't plan to bodybuild or compete, I just wanna look good and fix my health issues so I can feel good phisically and mentally.

 

[Luke391]

the GLP-1 inhibits hunger to where you only have room to eat whats essential..

Imagine the effect of eating only a tiny amount of shit food. As a sole source of nutrition.

not anymore. Even on the GLP1 by now I can eat a lot. I don'eat small amounts of shit food. I can eat large plates of vegetables and lean meat but still be hungry

 

[Stealth500]

And this is what I currently look like. I am small as shit I know. I don't plan to bodybuild or compete, I just wanna look good and fix my health issues so I can feel good phisically and mentally.View attachment 344702View attachment 344703

This is extremely lean.

 

[Stealth500]

not anymore. Even on the GLP1 by now I can eat a lot. I don'eat small amounts of shit food. I can eat large plates of vegetables and lean meat but still be hungry

the bodies natural reaction to walking around that lean 365 is going to happen.

 

[Luke391]

This is extremely lean.

I don't think I'm that lean. I carry a fuck ton of fat on my legs so I'm probably around 12-14%.
The light in those pics is maybe a bit too flattering.

 

[eery]

I don't think I'm that lean. I carry a fuck ton of fat on my legs so I'm probably around 12-14%.
The light in those pics is maybe a bit too flattering.

you are. Most people would be very hungry in general walking around like this, especially if you had a higher bodyweight or fat percentage most of your life to where your setpoint is generally higher.

you are being unrealistic.

 

[Sampei]

I don't think I'm that lean. I carry a fuck ton of fat on my legs so I'm probably around 12-14%.
The light in those pics is maybe a bit too flattering.

I almost believed you until you wrote this message, you have clearly mental health issues and I again I don't say it as an insult but I the hope you get help.

You are walking around stage lean ready and you are surprised your body is hungry? And you get hunger?

DUDE! YOU ARE STARVING YOURSELF! wtf is wrong with you lol you are like 7-8% BF and not much muscle, you have clearly a big case of body dysphoria. You need help not more drugs.

 

[phenominal34]

Who gives a shit if you eat a lot of food if you remain that lean ? Now it’s like you’re just out here for attention.

 

[Luke391]

Who gives a shit if you eat a lot of food if you remain that lean ? Now it’s like you’re just out here for attention.

I mean it's not really fun. I care about my health and I know how damaging it is to binge or eat junk and mentally it makes me feel shitty afterwards. And I do a lot to stay lean.
My initial question was about reducing the metabolic damage.
I posted pictures only to avoid the whole "just be disciplined fatass"

 

[Liter O' Test]

I mean it's not really fun. I care about my health and I know how damaging it is to binge or eat junk and mentally it makes me feel shitty afterwards. And I do a lot to stay lean.
My initial question was about reducing the metabolic damage.
I posted pictures only to avoid the whole "just be disciplined fatass"

what do you think "metabolic damage" is?
youre on 10mg of tirz and lean and talking about restoring insulin sensitivity
do you even measure your blood sugar?

this is still mental for you, food isnt bad, youre going to have to be very specific otherwise you are a paranoid ex fatty that doesnt know how the body works.

 

[ToesOverKnees]

Been overweight and Binge eating most of my life. Lost weight bunch of times naturally but always gained it back. Started Tirzepatide in February and it's been really amazing, it fixed the binge eating for a while but after loosing a bunch of weight the hunger and binging came back. Upper the dose and same thing happened, lost some more and binging came back.
I'm on 10mg and will keep upping the dose, but the question is: could using one of the supplements/drugs I listed in the title help to restore insulin sensitivity and the metabolic damage and inflammation caused by the binge episodes? Not used chronically, but only after the instances of overeating using like 1000-1500mg of Berberine phytosome or 500mg Metformin or 200-400g Acarbose (just one, not all 3 togheter)

Does it make sense or no? Possible drawbacks? I know metformin and berberine are a mithocondrial toxin and that acarbose is linked to decreased strenght, but I was thinking the intermittent use and the addition of mithocondrial efficiency supplements and peptides (like carnitine, coQ10 and mots-c) could limit the negatives.

Do you use a Continuous glucose monitor, a cgm? They can be really helpful because they show you the damage a binge does seeing blood glucose sky high.
By seeing that it can help the mental addiction to binging which is really a breakthrough.
Without that black n white feedback the binge is kinda a victimless crime if that makes sense

 

[Luke391]

Do you use a Continuous glucose monitor, a cgm? They can be really helpful because they show you the damage a binge does seeing blood glucose sky high.
By seeing that it can help the mental addiction to binging which is really a breakthrough.
Without that black n white feedback the binge is kinda a victimless crime if that makes sense

I will try that. thanks

 

[BamaCrazy]

Dude, you have a Body dysmorphic disorder. There’s nothing wrong with your physique. There’s something wrong with the way you perceive yourself. Plus staying that lean year round is unhealthy.