Blood Pressure and Plaque In The Arteries

[Avies48]

Lp(a) and elevated ApoB have a whole different set of genetic influences. Lp(a) is a carrier of ApoB, but only represents a small portion of total ApoB, the rest of which is bound to LDL. I can point to the SNPs in question if that helps.

Snp’s would be awesome to know

 

[Avies48]

I really don't want a statin, but my doc is insisting, and in order to get coverage for the more advanced treatments like BA or Repatha, it'll take a few months of "step therapy" in which I complain about statin sides before I can move on,

I have familial hyperlipidemia, so there's a genetic component to deal with. Statins induced serious muscle pain when I last tried one years ago.

So I was thinking of accepting the 2 different statin prescriptions required to qualify for the advanced meds, but actually taking Ez and/or BA in order to improve numbers, while waiting out the 4 months of required theater.

I took crestor for 2 weeks… had a clot… they said no more statins… i got repatha covered but in all honesty i wont touch it after reading all the aides and being in a few fb groups that have people just having horrible sides… ima try zetia, and ad b acid if needed… repatha is a last resort id rather try the pills that arent statins…

 

[Avies48]

Years ago a buddies mother had plugged up arteries and couldn't get the bypass or stent surgery for whatever reason. She saw a natty path and they administered sodium tetraboride. It was several years later we were at Xmas dinner and she was explaining that there was a chronic boron deficiency in all developed countries. The salts of boron regulate cholesterol and SHBG and that it helped her body metabolize the plaques. The Dr's were lost for words with near clear arteries.

She noted that her entire life, even with regular cleanings, plaque would build up in her mouth regardless of diet. With the administration of the boran salt the plaque in her mouth subsided overnight... And that lovely newphie lady is still with us today, I saw her this summer past at 77 years of age.

In the 60's there was a guy, I can't remember is he was british or Aussie or a combo, but he published a series of articles that claimed Sodium Tetraboride aka Borax had some pretty potent effects on the human body. Regulating cholesterol and SHBG was one of those claims.

The idea is that boron isn't that bioavailable and its also stripped from the soil with over production and modern fertilizer. So you need salts of boron to take it up. I think it was called the boron conspiracy or smething like that... If you want me to reach out to her I can, might be easier just to get an AI to 5000 word summary it for you though.

Ill have to find the insta video of the guys claiming borax is the answer to a lot of stuff…

 

[malfeasance]

my Hba1c . . . improved in the past 6 months from nearly 6 to 4.8

Wow, that's great!

but my insulin resistance is of the shits. It's actually insanely high and was really bad. Right now its at 5.9.

This is pretty easy to reverse with calorie restriction. It takes a little while.

"Our research has shown that modest weight reduction due to caloric restriction to about 1,200 calories a day leads to a reduction of liver fat and reversal of liver insulin resistance and type 2 diabetes. You don’t have to get down to the weight you were in high school—a 10% weight reduction can make a big difference. This is also likely the major mechanism by which the new GLP-1 agonist medications are working to reverse type 2 diabetes."

How to Reverse Insulin Resistance

In a Q&A, Gerald I. Shulman, MD, PhD, George R. Cowgill Professor of Medicine (Endocrinology) and professor of cellular and molecular physiology, discusses the

medicine.yale.edu

 

[malfeasance]

"Large adipocytes lead to lipid deposition in visceral and hepatic tissues, promoting insulin resistance. Calorie restriction by diet alone or with exercise reverses this trend."

Effect of Calorie Restriction With or Without Exercise on Insulin Sensitivity, β-Cell Function, Fat Cell Size, and Ectopic Lipid in Overweight Subjects - PMC

The purpose of this article was to determine the relationships among total body fat, visceral adipose tissue (VAT), fat cell size (FCS), ectopic fat deposition in liver (intra-hepatic lipid [IHL]) and muscle (intramyocellular lipid [IMCL]), and ...

pmc.ncbi.nlm.nih.gov

 

[Liter O' Test]

I took crestor for 2 weeks… had a clot… they said no more statins… i got repatha covered but in all honesty i wont touch it after reading all the aides and being in a few fb groups that have people just having horrible sides… ima try zetia, and ad b acid if needed… repatha is a last resort id rather try the pills that arent statins…

statins cause clots or less cholesterol causes?

 

[AlexDavis43]

Wow, that's great!

This is pretty easy to reverse with calorie restriction. It takes a little while.

"Our research has shown that modest weight reduction due to caloric restriction to about 1,200 calories a day leads to a reduction of liver fat and reversal of liver insulin resistance and type 2 diabetes. You don’t have to get down to the weight you were in high school—a 10% weight reduction can make a big difference. This is also likely the major mechanism by which the new GLP-1 agonist medications are working to reverse type 2 diabetes."

How to Reverse Insulin Resistance

In a Q&A, Gerald I. Shulman, MD, PhD, George R. Cowgill Professor of Medicine (Endocrinology) and professor of cellular and molecular physiology, discusses the

medicine.yale.edu

Shulman, Olefsky, Kahn, Leibel, Friedman, and a few others are really pioneers in this.

The reduction in liver fat occurs very early in the course of an energy deficit. Before statistically significant weight loss and surely before 10% (outside of water weight).

 

[AlexDavis43]

Shulman, Olefsky, Kahn, Leibel, Friedman, and a few others are really pioneers in this.

The reduction in liver fat occurs very early in the course of an energy deficit. Before statistically significant weight loss and surely before 10% (outside of water weight).

"Large adipocytes lead to lipid deposition in visceral and hepatic tissues, promoting insulin resistance. Calorie restriction by diet alone or with exercise reverses this trend."

Effect of Calorie Restriction With or Without Exercise on Insulin Sensitivity, β-Cell Function, Fat Cell Size, and Ectopic Lipid in Overweight Subjects - PMC

The purpose of this article was to determine the relationships among total body fat, visceral adipose tissue (VAT), fat cell size (FCS), ectopic fat deposition in liver (intra-hepatic lipid [IHL]) and muscle (intramyocellular lipid [IMCL]), and ...

pmc.ncbi.nlm.nih.gov

of course and Ravussin and a lot of work coming out of Pennington

 

[Bumpygooch]

@Ghoul I have FH as well. LDL as high as 250. Calcium score over 500, mom’s score was well over 1000. 20mg rosuvastatin got my LDL under 90 in 6 months. Several years of that, LDL down to 70 or so. DR wouldn’t give me ezetimibe, so, I got some from PCT and ran it at 10mg/day along with 10mg/dsy rosuvastatin for 6 months. LDL was relatively unchanged, DR agreed to give me the ezetimibe script. I don’t see a way around a statin with FH, unfortunately.

 

[Ghoul]

@Ghoul I have FH as well. LDL as high as 250. Calcium score over 500, mom’s score was well over 1000. 20mg rosuvastatin got my LDL under 90 in 6 months. Several years of that, LDL down to 70 or so. DR wouldn’t give me ezetimibe, so, I got some from PCT and ran it at 10mg/day along with 10mg/dsy rosuvastatin for 6 months. LDL was relatively unchanged, DR agreed to give me the ezetimibe script. I don’t see a way around a statin with FH, unfortunately.

Any sides?

 

[Bumpygooch]

Any sides?

My calves are tight in the morning the first 10 steps or so, but, I’m not sure that can even be attributed to the statin, honestly. Aside from that, none that I’ve felt. I take telmisartan, nebivolol and cialis(cilnidipine soon)as well, full disclosure

 

[Ghoul]

My calves are tight in the morning the first 10 steps or so, but, I’m not sure that can even be attributed to the statin, honestly. Aside from that, none that I’ve felt. I take telmisartan, nebivolol and cialis(cilnidipine soon)as well, full disclosure

How about memory loss?

 

[Bumpygooch]

How about memory loss?

Depends on what you would classify as “memory.” Sometimes words I use frequently kind of disappear, but, mom has the same word issue. I’ve attributed it to genetics and aging. I’ve heard the statin/dementia corollary before, mom came off her statins because Barbara O’Neill made that unsubstantiated claim. Same woman that claims castor oil is magic.

 

[Ghoul]

Depends on what you would classify as “memory.” Sometimes words I use frequently kind of disappear, but, mom has the same word issue. I’ve attributed it to genetics and aging. I’ve heard the statin/dementia corollary before, mom came off her statins because Barbara O’Neill made that unsubstantiated claim. Same woman that claims castor oil is magic.

Just curious, not lending any credence to it. From what I saw on balance it lowers the risk, but memory loss as a side could still have been a thing.

 

[Bumpygooch]

Just curious, not lending any credence to it. From what I saw on balance it lowers the risk, but memory loss as a side could still have been a thing.

I also don’t close the door on the possibility of it. Not a bad idea to reduce the statin dosage and add other meds if the same result can be achieved. BA next, love to get LDL into the 50s.

 

[Nidus]

Wow, that's great!

This is pretty easy to reverse with calorie restriction. It takes a little while.

"Our research has shown that modest weight reduction due to caloric restriction to about 1,200 calories a day leads to a reduction of liver fat and reversal of liver insulin resistance and type 2 diabetes. You don’t have to get down to the weight you were in high school—a 10% weight reduction can make a big difference. This is also likely the major mechanism by which the new GLP-1 agonist medications are working to reverse type 2 diabetes."

How to Reverse Insulin Resistance

In a Q&A, Gerald I. Shulman, MD, PhD, George R. Cowgill Professor of Medicine (Endocrinology) and professor of cellular and molecular physiology, discusses the

medicine.yale.edu

Thank you. I managed to improve my Homa by 0.3 nearly every 2-3 months and weightloss does indeed help a ton. I started out with nearly 180KG and now down to 125KG after 1.5 years.

I eat low carb, high protein and moderate fats to slow down the digestion of my meals. I have a stomach like a black hole, i am certain that all-you can buffet places would pay to leave

Every time i lost 10KG i pull labs to check again where i am at, so once i am at the 120 i will do a full panel as well which usually every 3 months.

Simply going based on the estimates and results i get from donating blood (they give you a small blood test for free here) my results overall improved about 16% every 2 months.

I already managed to fix so many other issues down this journey so i am not stopping anytime soon, life has been quite good and the quality you get by taking care of yourself is amazing.

 

[egruberman]

Snp’s would be awesome to know

Shit…. You called my bluff.

(I’ll look in a few)

 

[egruberman]

Snp’s would be awesome to know

Lp(A), in the LPA gene:
rs10455872
rs3798220
rs6415084
rs12194138

ApoB:
rs1042034 T allele
rs676210
rs693 T allele
rs7575840
rs515135 C allele.

There's a host of others as well. From my full genome scan, there are a number of things that showed up. SNPs and the effect are weighted and then a percentile relative to other users are given with regard to the expected effect. As you might guess, based on my activity here, the top results is:



Here's the complete list of SNPs. Most have a small effect:

Join Nebula Genomics

Nebula offers free DNA sequencing, insights into your genetics and ancestry, and data privacy protection. Contribute to medical breakthroughs and get rewarded for sharing your health and genomic data while maintaining privacy and control.

portal.nebula.org

 

[Nidus]

Lp(A), in the LPA gene:
rs10455872
rs3798220
rs6415084
rs12194138

ApoB:
rs1042034 T allele
rs676210
rs693 T allele
rs7575840
rs515135 C allele.

There's a host of others as well. From my full genome scan, there are a number of things that showed up. SNPs and the effect are weighted and then a percentile relative to other users are given with regard to the expected effect. As you might guess, based on my activity here, the top results is:

View attachment 322757

Here's the complete list of SNPs. Most have a small effect:

Join Nebula Genomics

Nebula offers free DNA sequencing, insights into your genetics and ancestry, and data privacy protection. Contribute to medical breakthroughs and get rewarded for sharing your health and genomic data while maintaining privacy and control.

portal.nebula.org

Thank you for the list, definitely something to note down for me!

If you dont mind me asking you, in my entire family tree, everyone has extremely high Triglycerides and Cholesterol but LipoA is generally below 10, i got one of 7 and ApoB is also extremely low within the family, highest i've seen was 48.

So while Cholesterol and Triglycerides are high, indicating high risk, one other side LipoA and apoB being so low that risk is rather small?

How can i understand that?

 

[AlexDavis43]

Thank you for the list, definitely something to note down for me!

If you dont mind me asking you, in my entire family tree, everyone has extremely high Triglycerides and Cholesterol but LipoA is generally below 10, i got one of 7 and ApoB is also extremely low within the family, highest i've seen was 48.

So while Cholesterol and Triglycerides are high, indicating high risk, one other side LipoA and apoB being so low that risk is rather small?

How can i understand that?

30000-foot view: high LDL or apoB are greater risk factors for men whereas high TGs is a greater risk factor for women.

In this context, for a man, low apoB would be more protective because higher TGs are less harmful (compared to for women).