Blood Pressure

[Ghoul]

Thank you for the info as always. I find it pretty interesting. I know also that apprently if needed you can take cilnidpline with nebivolol. If I ever do try that, I would lower the nebivolol down to 5mg and the cilnidipine as 5mg as well to start.

That being said, I know it is super new, but any thoughts on the next gen bp drug aprocitentan? Trivio. Works supposedly on a new mechanism.

Haven't looked into it yet, but I will now, thanks for bringing it to my attention.

I think I've found the ideal combo for me. Numbers are perfect, 115/65, and although BP usually isn't associated with "feeling it", whether high or well controlled, Cilnidipine's improved my quality of life.

The BP med issue I have is anxiety at the thought of losing access to Cilnipidine lol.

That said, Cilnipidine IS in Phase 3 trials in the US for approval as a Reynaud's treatment. But it'll be a pricey brand name drug for quite a while even after approval.

The good news is this trial once again demonstrates its safety and low/no sides just like every other trial since the 90s.

 

[BP_6]

Haven't looked into it yet, but I will now, thanks for bringing it to my attention.

I think I've found the ideal combo for me. Numbers are perfect, 115/65, and although BP usually isn't associated with "feeling it", whether high or well controlled, Cilnidipine's improved my quality of life.

The BP med issue I have is anxiety at the thought of losing access to Cilnipidine lol.

That said, Cilnipidine IS in Phase 3 trials in the US for approval as a Reynaud's treatment. But it'll be a pricey brand name drug for quite a while even after approval.

The good news is this trial once again demonstrates its safety and low/no sides just like every other trial since the 90s.

It is a shame it hasn't been approved for BP long ago in the USA. I know of not one single study or one single person that has taken both it and amlodpine and didn't think it was much better. Every bit as strong without the RHR or edema possible sides. I do understand though that no company is going to go through that expensive process if they don't think they can recoup their investment.

 

[Ghoul]

It is a shame it hasn't been approved for BP long ago in the USA. I know of not one single study or one single person that has taken both it and amlodpine and didn't think it was much better. Every bit as strong without the RHR or edema possible sides. I do understand though that no company is going to go through that expensive process if they don't think they can recoup their investment.

This is what happens when the window for exclusivity expires. The incentive to spend the millions necessary to get approval is the 10-15 years the company that introduces a new drug gets to charge high "brand name" prices before generics are allowed to come to market.

For whatever reason, the Japanese company that invented it started the FDA approval process, starting the clock, and at this point if they did spend the cash to get it approved for BP it could immediately be offered by others as a cheap generic. Plenty of companies in India have been making it for a while, at very low prices.

But by combining it with a small amount Tadalifil, for a new use, Reynaud's, its considered a new drug and the pharma company will get exclusivity after approval.

They were clever to recognize its use in treating Reynaud's. Because there are no other drugs specifically for that condition (CCBs have been prescribed off label for it), it was granted "orphan" status. That makes the approval process much easier and cheaper.

TLDR: In about 15 years cilnipidine (with a little Tadalafil) will finally be available as a cheap generic in the US, and can be prescribed "off label" for blood pressure.

Meanwhile when cost isn't an issue, it's the CCB of choice in Japan, South Korea, and India.

 

[BP_6]

I find it funny and saw a pharmacist show this before, that drug companies will sometime combine two generic, inexpensive drugs into a "combo" pill and patent it and charge a lot, lot more money than it would cost to buy the two medications separately.

 

[Ghoul]

I find it funny and saw a pharmacist show this before, that drug companies will sometime combine two generic, inexpensive drugs into a "combo" pill and patent it and charge a lot, lot more money than it would cost to buy the two medications separately.

Yeah, a lot of BP meds like that.

Telm/amlodipine = Twynsta
Valsartan/amlodipine = Exforge

The nice thing is studies are paid for by pharma companies demonstrating the effectiveness, while those with generous insurance plans get the brand name single pills, and those who don't still benefit from the combo by docs prescribing the generics as separate pills.

And now both combos are available as single pill generics. .

 

[themanhart]

140/90 is not too serious why are crying. quit the roids instead

 

[The Answ3r]

Still taking Moda?

Yes, still taking it, but only on training days now, and I’ve lowered the dose from 100mg to 75mg. Last time I took it was Thursday morning, and I checked my BP Friday - felt noticeably better on the lower dose. That spike I had might actually be from the EQ kicking in, since I’m just hitting week 3. I’ll keep monitoring it. Got Telmisartan, Cilnidipine, and Nebimax on standby just in case, but hopefully I won’t need to bring out the big guns.

 

[BamaCrazy]

Yes, still taking it, but only on training days now, and I’ve lowered the dose from 100mg to 75mg. Last time I took it was Thursday morning, and I checked my BP Friday - felt noticeably better on the lower dose. That spike I had might actually be from the EQ kicking in, since I’m just hitting week 3. I’ll keep monitoring it. Got Telmisartan, Cilnidipine, and Nebimax on standby just in case, but hopefully I won’t need to bring out the big guns.

Well I’m glad it’s back to normal.

I assume since you are using EQ you are keeping a closer eye on your RBC and hematocrit? Thicker blood won’t help BP.

 

[The Answ3r]

Well I’m glad it’s back to normal.

I assume since you are using EQ you are keeping a closer eye on your RBC and hematocrit? Thicker blood won’t help BP.

Absolutely, I keep a close eye on RBC and hematocrit - especially with EQ in the mix. I usually get bloodwork done around week 5, and the highest hematocrit I’ve ever seen on myself was 53%, which honestly felt fine overall. Still, I went ahead and donated blood just to play it safe - it wasn’t 100% necessary, but figured it wouldn’t hurt.

That said, I do daily cardio, drink plenty of water, and generally stay on top of it. But yeah, with EQ doing its thing, it might be time soon to swap it out for some Primo - cleaner, easier, and no hematocrit games.

 

[BamaCrazy]

Thank you for the info as always. I find it pretty interesting. I know also that apprently if needed you can take cilnidpline with nebivolol. If I ever do try that, I would lower the nebivolol down to 5mg and the cilnidipine as 5mg as well to start.

That being said, I know it is super new, but any thoughts on the next gen bp drug aprocitentan? Trivio. Works supposedly on a new mechanism.

From what I read it can be used with other antihypertensive drugs when your BP is resistant to other treatments. My concern would be the edema and liver toxicity. I think the edema is more common and liver toxicity is less common.

 

[Jron]

Using 200mg test a week and 100mg Moda and 100mg caffeine a day.

Blood pressure was hitting 130/70. Starting throwing beet root supplement in at night and 2.5’mg oral minox. Both of which knock that systolic blood pressure back down to like 123/70 which is good enough.

I’m also 6 foot and like 165 pounds so not exactly huge. Lots of cardio.

 

[oldmanwilliams]

My blood pressure is ok but my heart rate is always too high but no doctor seems concerned but I just don't think averaging 100-120 beats per minute is a good thing. Any recommendations here?

 

[BamaCrazy]

My blood pressure is ok but my heart rate is always too high but no doctor seems concerned but I just don't think averaging 100-120 beats per minute is a good thing. Any recommendations here?

I’m not recommending you take these, but Beta-Blockers like metoprolol, carvedilol, and atenolol are prescribed to people with AFib. But their heart rates are 150+. They would likely make you feel sleepy with a lower HR than 150.

100-120 does seem high though. Over 100 is considered tachycardia so it’s odd they are not concerned.

Also, what do you consider good BP?

 

[oldmanwilliams]

I’m not recommending you take these, but Beta-Blockers like metoprolol, carvedilol, and atenolol are prescribed to people with AFib. But their heart rates are 150+. They would likely make you feel sleepy with a lower HR than 150.

100-120 does seem high though. Over 100 is considered tachycardia so it’s odd they are not concerned.

Also, what do you consider good BP?

You know, I feel comfortable at.....130/80 and psychologically I start to get concerned when it steps up to like 140/90.

Every doctor I've ever been too has dismissed it but I know that it's too high. Nebivolol doesn't touch the heart rate but that's the one I like. I use it with Telmisartan and the combination works OK but not perfect but side effect it is the best. Other beta blockers are too strong for me. It's a tough position to be in. I'd really like to lower my heart rate.

 

[BP_6]

You know, I feel comfortable at.....130/80 and psychologically I start to get concerned when it steps up to like 140/90.

Every doctor I've ever been too has dismissed it but I know that it's too high. Nebivolol doesn't touch the heart rate but that's the one I like. I use it with Telmisartan and the combination works OK but not perfect but side effect it is the best. Other beta blockers are too strong for me. It's a tough position to be in. I'd really like to lower my heart rate.

Ivabradine. Doesn't have too much of an effect on BP, but is often used to slow heart rate.

 

[oldmanwilliams]

Ivabradine. Doesn't have too much of an effect on BP, but is often used to slow heart rate.

I'm very interested in this one. It sounds almost too good to be true. Do you have any experience with it?

 

[BP_6]

I'm very interested in this one. It sounds almost too good to be true. Do you have any experience with it?

Me personally no, but I have seen somewhere someone on her got some from PCT and tried it. I'll see if I can find it. I have also seen some other reports on other boards.

 

[BamaCrazy]

I'm very interested in this one. It sounds almost too good to be true. Do you have any experience with it?

Check this link out. This member uses Ivabradine

https://thinksteroids.com/community/threads/anxiety-overthinking-on-blast.134426896/page-2#post-3464601

 

[VakarianSK]

I'm very interested in this one. It sounds almost too good to be true. Do you have any experience with it?

A few people use it on the PM forum and that's where I first heard about it. I have been using it for a few months now and it's amazing imo. Completely dropped my elevated heart rate from reta and high dosed HGH back to before I was even enhanced. I also combine it with nebovolol as well. You can get both from @PCT24X7 PHARMACY .

 

[oldmanwilliams]

A few people use it on the PM forum and that's where I first heard about it. I have been using it for a few months now and it's amazing imo. Completely dropped my elevated heart rate from reta and high dosed HGH back to before I was even enhanced. I also combine it with nebovolol as well. You can get both from @PCT24X7 PHARMACY .

That's awesome. And do you feel any rebound effect when you stop taking it?