Bloodwork 6 week into test and primo. Low shgb

[bigmeesh]

I have low shgb. I’m running 400 test and 200 primo. Should I be worried about getting my shgb up. I figured it’s from the primo. This run the primo has kept my E2 in check. What do you guys advise? And the November results are pre cycle.

Thanks!

 

[Trades]

what issue are you trying to resolve by raising shbg?

advice is to train hard, eat well, and rest well to get the most of your 600mg aas cycle. and stop thinking about shbg

 

[AJDC]

SHBG is one of the harder things to modulate on cycle.

what issue are you trying to resolve by raising shbg?

This is important. You want to treat the symptoms and not the numbers.

If I were you, I would lower some primo, (or raise test) to get 40-50 E2 to increase HGH to IGF-1 conversion and would be about it.
A bit higher E2 could also help raise SHBG.

 

[bigmeesh]

I’m not having any sides. I just hadn’t had this happen my last cycle so I just decided to reach out here and see what was suggested

 

[Trades]

SHBG is one of the harder things to modulate on cycle.

This is important. You want to treat the symptoms and not the numbers.

If I were you, I would lower some primo, (or raise test) to get 40-50 E2 to increase HGH to IGF-1 conversion and would be about it.
A bit higher E2 could also help raise SHBG.

i think what i was trying to get at is that primo and many (all?) aas lower shbg, some more than others--is it a flaw or a feature? what would be the point in raising shbg while on cycle, and wouldn't raising shbh lower free test?

 

[bigmeesh]

i think what i was trying to get at is that primo and many (all?) aas lower shbg, some more than others--is it a flaw or a feature? what would be the point in raising shbg while on cycle, and wouldn't raising shbh lower free test?

Yeah it sounds like a plus. I just wanted to also make sure that it wasn’t going to harm me in anyway as well.

 

[readalot]

and wouldn't raising shbh lower free test?

I'd bet no based on my relevant data. Serum Free Test is invariant to changes in SHBG while under the constraint of constant exogenous testosterone. The body takes test ester and absorbs free test. The body eliminates free test. SHBG and Total Test are outputs not inputs.

Unfortunately due to the evolution of TT and then FT testing along with advent of calculated FT we've come to think of this backwards. The body snaps your TT to reflect SHBG given fast equilibrium with FT.

You can try this experiment yourself. Stay with constant Test dose, measure at trough with and without oxandrolone. Give enough time for oxandrolone to washout (4 weeks is plenty).

 

[bigmeesh]

The last cycle it was at 15 and this one is at 6. Just the difference for my worries is all.

 

[Trades]

Yeah it sounds like a plus. I just wanted to also make sure that it wasn’t going to harm me in anyway as well.

i agree with the other guy though, i'd want to get my E2 up to the 40s at least. i've run my E2 into the ground with primo on previous cycles and it ended with bicep tendonitis that still hasn't healed 12mos later

 

[Trades]

I'd bet no based on my relevant data. Serum Free Test is invariant to changes in SHBG while under the constraint of constant exogenous testosterone. The body takes test ester and absorbs free test. The body eliminates free test. SHBG and Total Test are outputs not inputs.

thanks for the clarification. i was under the mistaken impression that shbg and free test are somewhat inversely related.

 

[readalot]

thanks for the clarification. i was under the mistaken impression that shbg and free test are somewhat inversely related.

I've got an experiment in process using oxandrolone and equilibrium dialysis measurement. My prior experiments used calculated FT.

Paradox TRT results, very low SHBG

A few points to consider: Your T is fake. No offense, but looks legit and seems reputable doesn’t make it so. It’s a risk with UGL and you lost this time. Even with low SHBG, 3x weekly would be enough to see a serum T increase. Your PRL is a bit high. Your SHBG was low before TRT. Very, very...

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[bigmeesh]

SHBG is one of the harder things to modulate on cycle.

This is important. You want to treat the symptoms and not the numbers.

If I were you, I would lower some primo, (or raise test) to get 40-50 E2 to increase HGH to IGF-1 conversion and would be about it.
A bit higher E2 could also help raise SHBG.

Which would be better to do lower primo or just raise the test the little? Or just pick one?

 

[AJDC]

i think what i was trying to get at is that primo and many (all?) aas lower shbg, some more than others--is it a flaw or a feature? what would be the point in raising shbg while on cycle, and wouldn't raising shbh lower free test?

Well, what I understand is that SHBG helps in transporting androgens to the muscle which could actually would help anabolism through another anabolic pathway. It apparently doesn't just bind to androgens and make them inactive.

On the other hand, PEDs have been used for years and people still get big with very low SHBGs so in the end it shouldn't really matter for muscle gain

 

[AJDC]

Which would be better to do lower primo or just raise the test the little? Or just pick one?

You would have to experiment.

I would raise test dose maybe by 50-100mg and test E2 again in 4-6 weeks.
That info is going to help you find a good Test to Primo ratio for optimal E2

 

[xrayphoton13]

Your e2 is getting a little on the low end. I would want to get it up into the 40s if not higher. I'm cruising at 50 e2. I guess if you aren't having issues that's fine but it does seem like the primo is bringing your e2 down and you definitely don't want it to keep dropping. Maybe up the test or lower the primo. Just my 2 cents.

 

[bigmeesh]

Your e2 is getting a little on the low end. I would want to get it up into the 40s if not higher. I'm cruising at 50 e2. I guess if you aren't having issues that's fine but it does seem like the primo is bringing your e2 down and you definitely don't want it to keep dropping. Maybe up the test or lower the primo. Just my 2 cents.

I decided to lower the primo a little

 

[Dirthand]

i agree with the other guy though, i'd want to get my E2 up to the 40s at least. i've run my E2 into the ground with primo on previous cycles and it ended with bicep tendonitis that still hasn't healed 12mos later

Does low e2 somehow cause high risk for tendinitis?

 

[-Maui-]

I have low shgb. I’m running 400 test and 200 primo. Should I be worried about getting my shgb up. I figured it’s from the primo. This run the primo has kept my E2 in check. What do you guys advise? And the November results are pre cycle.

Thanks!

Hey!
Low SHBG is good for cycle!
That's why your free testosterone is so high.
Don't worry. You have a good BW results.

 

[Trades]

Does low e2 somehow cause high risk for tendinitis?

I cannot speak to a correlation between low estrogen and tendonitis, I have just observed with myself that my first couple of cycles with primo, where primo:test is close to 1:1, E2 ends up in the gutter and I get weird cramps and tendonitis flare ups. 2:1 test to primo, or even 3:1 is where I like to run it.

 

[Dirthand]

I cannot speak to a correlation between low estrogen and tendonitis, I have just observed with myself that my first couple of cycles with primo, where primo:test is close to 1:1, E2 ends up in the gutter and I get weird cramps and tendonitis flare ups. 2:1 test to primo, or even 3:1 is where I like to run it.

I did some reading and found that low e2 can hinder your muscle recovery that can also pull away from tendon and ligament recovery causing a greater risk of developing tendonitis. However I do not remember where I read it so I'm not saying this is true or science. It was just Interesting.